HitPredict

Interactor 1: SPA2 (P23201)
Protein SPA2
Gene: SPA2

Interactor 2: MKK1 (P32490)
MAP kinase kinase MKK1/SSP32 (EC 2.7.12.2)
Gene: MKK1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.625

Property	Details
Experiments	9632790, 20489023
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005934 - cellular bud tip GO:0005935 - cellular bud neck GO:0043332 - mating projection tip
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1466 Sc			1 508
+	Sc
		613047 SPA2_YEAST (1-1466): 0: 592: 100.00		MKK2_YEAST (1-507): 1.25e-126: 380: 55.60
+	Sc
		420011 SPA2_YEAST (1-1466): 0: 592: 100.00		STE7_YEAST (168-488): 4.27e-49: 178: 36.50
+	Sc
		691214 SPH1_YEAST (4-120): 8.12e-26: 116: 32.48		MKK1_YEAST (1-508): 3.64e-151: 443: 100.00
+	Hs
		160565 MDC1_HUMAN (77-1308): 2.17e-31: 136: 8.89		AURKA_HUMAN (90-500): 1.01e-122: 366: 24.03
+	Sc
		691245 SPH1_YEAST (4-120): 8.12e-26: 116: 32.48		MKK2_YEAST (1-507): 1.25e-126: 380: 55.60
+	Rn
		1144344 GIT1_RAT (38-493): 1.1e-25: 116: 17.08		AKT3_RAT (119-502): 2.3e-122: 368: 18.30
+	Hs
		625528 TITIN_HUMAN (398-1268): 1.27e-19: 98.7: 7.93		CDK2_HUMAN (218-499): 1.01e-123: 365: 20.86
+	Hs
		625394 AHNK_HUMAN (534-1094): 2.02e-09: 65: 16.75		CDK2_HUMAN (218-499): 1.01e-123: 365: 20.86
+	Hs
		734933 MDC1_HUMAN (77-1308): 2.17e-31: 136: 8.89		MP2K2_HUMAN (213-489): 7.51e-59: 201: 39.38
+	Sc
		420034 SPH1_YEAST (4-120): 8.12e-26: 116: 32.48		STE7_YEAST (168-488): 4.27e-49: 178: 36.50