HitPredict

Interactor 1: SFPQ (P23246)
Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor)
Gene: SFPQ

Interactor 2: HNRH1 (P31943)
Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed]
Gene: HNRNPH1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	NOPS~RRM_1, RRM_1~RRM_1, RRM_1~zf-RNPHF
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 707 Hs			1 449
+	Hs
		516495 PABP4_HUMAN (287-694): 8.34e-83: 277: 17.38		PABP1_HUMAN (1-446): 2.77e-84: 272: 13.70
+	Hs
		516339 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		PABP1_HUMAN (1-446): 2.77e-84: 272: 13.70
+	Hs
		516689 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		PABP3_HUMAN (1-446): 8.68e-79: 258: 12.42
+	Hs
		1031404 PSPC1_HUMAN (230-707): 1.7e-60: 213: 51.96		PABP4_HUMAN (1-447): 8.75e-85: 274: 13.92
+	Hs
		516608 PSPC1_HUMAN (230-707): 1.7e-60: 213: 51.96		PABP1_HUMAN (1-446): 2.77e-84: 272: 13.70
+	Hs
		682821 NONO_HUMAN (265-707): 1.49e-70: 239: 56.98		HNRH1_HUMAN (1-449): 1.86e-75: 244: 100.00
+	Mm
		936573 NONO_MOUSE (233-707): 2.48e-67: 231: 55.04		HNRH2_MOUSE (1-449): 2.44e-72: 236: 95.77
+	Hs
		516635 PABP5_HUMAN (244-545): 3.2e-43: 162: 15.34		PABP1_HUMAN (1-446): 2.77e-84: 272: 13.70
+	Hs
		474021 PABP4_HUMAN (287-694): 8.34e-83: 277: 17.38		PAB4L_HUMAN (3-188): 3.01e-38: 144: 15.03
+	Hs
		1119141 PABP5_HUMAN (244-545): 3.2e-43: 162: 15.34		PAP1L_HUMAN (1-432): 1.34e-75: 249: 12.20
+	Sc
		376562 PABP_YEAST (293-687): 2.32e-69: 239: 15.84		PABP_YEAST (104-380): 3.85e-35: 139: 14.84
+	Hs
		582066 SFPQ_HUMAN (1-707): 4.51e-74: 255: 100.00		NUCL_HUMAN (75-373): 1.19e-09: 62.5: 18.89
+	Hs
		474034 PABP5_HUMAN (244-545): 3.2e-43: 162: 15.34		PAB4L_HUMAN (3-188): 3.01e-38: 144: 15.03
+	Hs
		516355 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		NUCL_HUMAN (75-373): 1.19e-09: 62.5: 18.89
+	Dm
		597049 PABP_DROME (296-675): 1.13e-65: 230: 14.32		RB27C_DROME (5-92): 5.6e-09: 59.8: 18.18
+	Hs
		582407 PSPC1_HUMAN (230-707): 1.7e-60: 213: 51.96		NUCL_HUMAN (75-373): 1.19e-09: 62.5: 18.89
+	Hs
		1288653 PABP5_HUMAN (244-545): 3.2e-43: 162: 15.34		RBM19_HUMAN (286-371): 5.37e-16: 82.5: 33.72