HitPredict

Interactor 1: SFPQ (P23246)
Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor)
Gene: SFPQ

Interactor 2: PRC2A (P48634)
Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2)
Gene: PRRC2A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 707 Hs			1 2157
+	Hs
		820908 PABP4_HUMAN (287-694): 8.34e-83: 277: 17.38		PRC2A_HUMAN (1-2157): 4.11e-162: 555: 100.00
+	Hs
		516406 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		PRC2A_HUMAN (1-2157): 4.11e-162: 555: 100.00
+	Hs
		820986 PSPC1_HUMAN (230-707): 1.7e-60: 213: 51.96		PRC2A_HUMAN (1-2157): 4.11e-162: 555: 100.00
+	Hs
		516546 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		PRC2B_HUMAN (1-2145): 2.51e-121: 430: 25.60
+	Hs
		1127659 PSPC1_HUMAN (230-707): 1.7e-60: 213: 51.96		PRC2B_HUMAN (1-2145): 2.51e-121: 430: 25.60
+	Hs
		516595 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		KMT2C_HUMAN (79-2077): 7.51e-50: 199: 10.05
+	Hs
		965106 NONO_HUMAN (265-707): 1.49e-70: 239: 56.98		ANK2_HUMAN (12-1866): 6e-46: 186: 11.09
+	Hs
		965152 PABP3_HUMAN (287-700): 9.1e-69: 239: 16.88		ANK2_HUMAN (12-1866): 6e-46: 186: 11.09
+	Hs
		613619 SFPQ_HUMAN (1-707): 4.51e-74: 255: 100.00		SRRM2_HUMAN (238-2035): 2.29e-34: 147: 9.83
+	Hs
		516749 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		SRRM2_HUMAN (238-2035): 2.29e-34: 147: 9.83
+	Hs
		1069826 NONO_HUMAN (265-707): 1.49e-70: 239: 56.98		SRRM2_HUMAN (238-2035): 2.29e-34: 147: 9.83
+	Hs
		1031405 PABP4_HUMAN (287-694): 8.34e-83: 277: 17.38		TITIN_HUMAN (25-1264): 8.01e-19: 96.8: 11.60
+	Hs
		516609 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		TITIN_HUMAN (25-1264): 8.01e-19: 96.8: 11.60
+	Hs
		613456 SFPQ_HUMAN (1-707): 4.51e-74: 255: 100.00		MDC1_HUMAN (907-2156): 1.96e-13: 78.7: 10.22
+	Hs
		613628 SFPQ_HUMAN (1-707): 4.51e-74: 255: 100.00		PRC2C_HUMAN (33-1884): 4.13e-12: 74.4: 11.13
+	Hs
		613557 SFPQ_HUMAN (1-707): 4.51e-74: 255: 100.00		CIC_HUMAN (8-701): 6.41e-09: 63.9: 8.78
+	Hs
		516766 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		PRC2C_HUMAN (33-1884): 4.13e-12: 74.4: 11.13
+	Hs
		1288650 PABP5_HUMAN (244-545): 3.2e-43: 162: 15.34		SRRM2_HUMAN (238-2035): 2.29e-34: 147: 9.83
+	Hs
		1069770 NONO_HUMAN (265-707): 1.49e-70: 239: 56.98		CIC_HUMAN (8-701): 6.41e-09: 63.9: 8.78
+	Hs
		1263596 PSPC1_HUMAN (230-707): 1.7e-60: 213: 51.96		PRC2C_HUMAN (33-1884): 4.13e-12: 74.4: 11.13