Protein: MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)

Gene: MACF1
Organism: Homo sapiens
Interactions: 212
UniProt ID: Q9UPN3

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003779 - actin binding
GO:0005198 - structural molecule activity
GO:0005509 - calcium ion binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1152297

MARE1
Microtubule-associated protein RP/EB family member 1

6

13

Small-scale

0.948

High

1143304

PLEC
Plectin

3

17

High-throughput

0.827

High

302126

CDKL5
Cyclin-dependent kinase-like 5

2

15

High-throughput

0.789

High

891889

GSK3B
Glycogen synthase kinase-3 beta

2

18

High-throughput

0.754

High

1461052

TNIK
TRAF2 and NCK-interacting protein kinase

2

20

High-throughput

0.743

High

249214

DSCAM
Cell adhesion molecule DSCAM

1

11

High-throughput

0.698

High

853868

MK09
Mitogen-activated protein kinase 9

1

10

High-throughput

0.698

High

1116465

FHL1
Four and a half LIM domains protein 1

1

8

High-throughput

0.698

High

389567

FINC
Fibronectin

1

14

High-throughput

0.691

High

1030712

ANK2
Ankyrin-2

1

20

High-throughput

0.691

High

1396067

SCYL1
N-terminal kinase-like protein

1

13

High-throughput

0.691

High

1462482

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

5

High-throughput

0.691

High

1369096

NRCAM
Neuronal cell adhesion molecule

1

9

Small-scale

0.656

High

397225

ESR1
Estrogen receptor

3

20

High-throughput

0.650

High

1006799

SRPK2
SRSF protein kinase 2

1

12

High-throughput

0.647

High

1051981

KPCD
Protein kinase C delta type

1

5

Small-scale

0.647

High

1391857

AURKB
Aurora kinase B

1

6

High-throughput

0.618

High

157994

CTRO
Citron Rho-interacting kinase

1

20

High-throughput

0.618

High

440243

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.618

High

463842

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

643140

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

8

High-throughput

0.618

High

692161

MARK3
MAP/microtubule affinity-regulating kinase 3

1

6

Small-scale

0.618

High

710574

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

773085

MYH9
Myosin-9

1

12

High-throughput

0.618

High

791843

SYUA
Alpha-synuclein

1

3

High-throughput

0.618

High

878584

PAXI
Paxillin

1

12

High-throughput

0.618

High

891359

GSK3A
Glycogen synthase kinase-3 alpha

1

17

High-throughput

0.618

High

953184

ACTB
Actin, cytoplasmic 1

1

20

High-throughput

0.618

High

998110

CSK21
Casein kinase II subunit alpha

1

16

High-throughput

0.618

High

1040405

DYST
Dystonin

1

18

High-throughput

0.618

High

1051080

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.618

High

1146494

KS6A2
Ribosomal protein S6 kinase alpha-2

1

5

High-throughput

0.618

High

1156245

ZYX
Zyxin

1

5

High-throughput

0.618

High

1252296

SYNE3
Nesprin-3

1

20

High-throughput

0.618

High

1256108

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.618

High

1459530

TES
Testin

1

19

High-throughput

0.618

High

1462480

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

17

High-throughput

0.618

High

1462481

MARE3
Microtubule-associated protein RP/EB family member 3

1

13

High-throughput

0.618

High

1404513

CDC5L
Cell division cycle 5-like protein

2

10

High-throughput

0.614

High

343505

SNP29
Synaptosomal-associated protein 29

2

1

High-throughput

0.611

High

767516

RADI
Radixin

2

18

High-throughput

0.611

High

1114664

CUL3
Cullin-3

2

15

High-throughput

0.611

High

619955

VCAM1
Vascular cell adhesion protein 1

2

14

High-throughput

0.601

High

944100

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

20

High-throughput

0.590

High

1385054

CHP3
Calcineurin B homologous protein 3

1

3

High-throughput

0.590

High

1448563

DISC1
Disrupted in schizophrenia 1 protein

2

10

High-throughput

0.590

High

1450293

EXOC1
Exocyst complex component 1

2

3

High-throughput

0.590

High

272551

OBSL1
Obscurin-like protein 1

2

20

High-throughput

0.584

High

373504

MYC
Myc proto-oncogene protein

2

14

High-throughput

0.584

High

730352

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.584

High

972132

1433E
14-3-3 protein epsilon

2

4

High-throughput

0.584

High

990871

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.584

High

1398400

CEP63
Centrosomal protein of 63 kDa

3

20

High-throughput

0.576

High

930083

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

11

Small-scale

0.561

High

1433472

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

20

High-throughput

0.555

High

1461696

HECD1
E3 ubiquitin-protein ligase HECTD1

1

12

High-throughput

0.553

High

1371778

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

11

Small-scale

0.543

High

340263

PCNT
Pericentrin

1

20

High-throughput

0.541

High

430513

JUN
Transcription factor Jun

1

6

High-throughput

0.541

High

668757

APC
Adenomatous polyposis coli protein

1

20

High-throughput

0.541

High

938187

PKNX1
Homeobox protein PKNOX1

1

1

High-throughput

0.541

High

564566

CFTR
Cystic fibrosis transmembrane conductance regulator

1

9

High-throughput

0.536

High

602854

AATC
Aspartate aminotransferase, cytoplasmic

1

4

High-throughput

0.536

High

872892

SOX2
Transcription factor SOX-2

1

11

High-throughput

0.536

High

1036559

ID2
DNA-binding protein inhibitor ID-2

1

1

High-throughput

0.536

High

1206029

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

20

High-throughput

0.536

High

106859

APRIO
Alternative prion protein

2

10

High-throughput

0.533

High

1351615

MIPT3
TRAF3-interacting protein 1

2

6

High-throughput

0.526

High

444023

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

2

High-throughput

0.515

High

1039455

RL6
Large ribosomal subunit protein eL6

1

1

High-throughput

0.515

High

1134767

NUMA1
Nuclear mitotic apparatus protein 1

1

20

High-throughput

0.515

High

1414171

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

1

0

High-throughput

0.513

High

555536

SKIL
Ski-like protein

1

3

High-throughput

0.508

High

880984

MTR1B
Melatonin receptor type 1B

1

9

High-throughput

0.508

High

1389814

DTBP1
Dysbindin

1

4

High-throughput

0.508

High

1459794

CNTP2
Contactin-associated protein-like 2

1

12

Small-scale

0.508

High

1462483

PLXD1
Plexin-D1

1

5

Small-scale

0.508

High

1399282

LRRC7
Leucine-rich repeat-containing protein 7

1

7

Small-scale

0.504

High

508840

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

9

High-throughput

0.501

High

333415

SNAPN
SNARE-associated protein Snapin

1

4

High-throughput

0.494

High

874015

NRIP1
Nuclear receptor-interacting protein 1

1

3

High-throughput

0.494

High

66819

C2C4B
C2 calcium-dependent domain-containing protein 4B

1

1

High-throughput

0.489

High

326211

ALX3
Homeobox protein aristaless-like 3

1

4

High-throughput

0.489

High

1462485

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

1

High-throughput

0.489

High

1420803

TNG6
Transport and Golgi organization protein 6 homolog

1

0

Small-scale

0.486

High

543601

ERR1
Steroid hormone receptor ERR1

1

20

High-throughput

0.481

High

946284

NRX1B
Neurexin-1-beta

1

4

Small-scale

0.481

High

946296

NRX2B
Neurexin-2-beta

1

4

Small-scale

0.481

High

1461336

TEN1
Teneurin-1

1

5

Small-scale

0.481

High

159923

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

14

High-throughput

0.479

High

226266

STX6
Syntaxin-6

1

7

High-throughput

0.479

High

248143

NUPR1
Nuclear protein 1

1

5

High-throughput

0.479

High

250897

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

1

High-throughput

0.479

High

299432

FLOT1
Flotillin-1

1

7

High-throughput

0.479

High

325165

HEXI1
Protein HEXIM1

1

1

High-throughput

0.479

High

331422

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

346506

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

5

High-throughput

0.479

High

409133

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

High-throughput

0.479

High

459803

PROF1
Profilin-1

1

4

High-throughput

0.479

High

475064

VIME
Vimentin

1

20

Small-scale

0.479

High

480354

RU1C
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.479

High

522017

H14
Histone H1.4

1

4

High-throughput

0.479

High

535678

BIP
Endoplasmic reticulum chaperone BiP

1

11

High-throughput

0.479

High

540755

LAMP1
Lysosome-associated membrane glycoprotein 1

1

13

High-throughput

0.479

High

556426

CADH1
Cadherin-1

1

13

High-throughput

0.479

High

566077

EF2
Elongation factor 2

1

8

High-throughput

0.479

High

574517

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

2

High-throughput

0.479

High

583026

EZRI
Ezrin

1

20

High-throughput

0.479

High

604274

CXA1
Gap junction alpha-1 protein

1

14

High-throughput

0.479

High

613486

VINC
Vinculin

1

14

High-throughput

0.479

High

631565

RAB5A
Ras-related protein Rab-5A

1

13

High-throughput

0.479

High

651026

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

2

High-throughput

0.479

High

691538

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

702061

TMOD1
Tropomodulin-1

1

4

High-throughput

0.479

High

720073

HMOX2
Heme oxygenase 2

1

1

High-throughput

0.479

High

730959

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

764471

CTNA1
Catenin alpha-1

1

11

High-throughput

0.479

High

856988

BAG6
Large proline-rich protein BAG6

1

8

High-throughput

0.479

High

866872

CAZA2
F-actin-capping protein subunit alpha-2

1

8

High-throughput

0.479

High

881111

NASP
Nuclear autoantigenic sperm protein

1

4

High-throughput

0.479

High

888393

MCM2
DNA replication licensing factor MCM2

1

11

High-throughput

0.479

High

899284

TCPQ
T-complex protein 1 subunit theta

1

3

High-throughput

0.479

High

905292

MECP2
Methyl-CpG-binding protein 2

1

10

High-throughput

0.479

High

959296

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.479

High

967024

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

985072

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.479

High

986815

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

4

High-throughput

0.479

High

1035996

KIF23
Kinesin-like protein KIF23

1

20

High-throughput

0.479

High

1041371

CAV1
Caveolin-1

1

15

High-throughput

0.479

High

1045911

TF65
Transcription factor p65

1

12

High-throughput

0.479

High

1049907

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1065785

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

20

High-throughput

0.479

High

1099823

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

2

High-throughput

0.479

High

1101101

G3BP1
Ras GTPase-activating protein-binding protein 1

1

4

High-throughput

0.479

High

1123876

DCTN1
Dynactin subunit 1

1

18

High-throughput

0.479

High

1128867

NBR1
Next to BRCA1 gene 1 protein

1

4

High-throughput

0.479

High

1135179

CUL7
Cullin-7

1

9

High-throughput

0.479

High

1138756

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

8

High-throughput

0.479

High

1141044

KIF14
Kinesin-like protein KIF14

1

14

High-throughput

0.479

High

1159907

OCLN
Occludin

1

7

High-throughput

0.479

High

1229138

RNF43
E3 ubiquitin-protein ligase RNF43

1

7

High-throughput

0.479

High

1253248

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

20

High-throughput

0.479

High

1278232

CLAP1
CLIP-associating protein 1

1

4

High-throughput

0.479

High

1323784

S39AB
Zinc transporter ZIP11

1

4

High-throughput

0.479

High

1352202

GRHL3
Grainyhead-like protein 3 homolog

1

6

High-throughput

0.479

High

1364696

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

11

High-throughput

0.479

High

1368974

GOGA1
Golgin subfamily A member 1

1

20

High-throughput

0.479

High

1380255

FBXW7
F-box/WD repeat-containing protein 7

1

14

High-throughput

0.479

High

1385921

CHM4C
Charged multivesicular body protein 4c

1

20

High-throughput

0.479

High

1386632

OPTN
Optineurin

1

20

High-throughput

0.479

High

1399793

RBM14
RNA-binding protein 14

1

1

High-throughput

0.479

High

1405154

DNJC2
DnaJ homolog subfamily C member 2

1

1

High-throughput

0.479

High

1421011

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.479

High

1430640

CCDC8
Coiled-coil domain-containing protein 8

1

8

High-throughput

0.479

High

1434240

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

1436558

ECT2
Protein ECT2

1

20

High-throughput

0.479

High

1447445

ANLN
Anillin

1

14

High-throughput

0.479

High

1448244

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

13

High-throughput

0.479

High

1454773

HECW2
E3 ubiquitin-protein ligase HECW2

1

6

High-throughput

0.479

High

1459322

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

1462484

LOXL2
Lysyl oxidase homolog 2

1

3

High-throughput

0.479

High

1420656

CNTP4
Contactin-associated protein-like 4

1

12

Small-scale

0.464

High

1461394

RAB21
Ras-related protein Rab-21

1

15

Small-scale

0.462

High

134912

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.458

High

208095

TTI1
TELO2-interacting protein 1 homolog

1

0

High-throughput

0.458

High

365492

PGK1
Phosphoglycerate kinase 1

1

0

High-throughput

0.458

High

1271910

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

1332395

TTC29
Tetratricopeptide repeat protein 29

1

0

High-throughput

0.458

High

1450008

LMBD1
Lysosomal cobalamin transport escort protein LMBD1

1

0

High-throughput

0.458

High

1452038

TRM1
tRNA

1

0

High-throughput

0.458

High

1057048

FMR1
Fragile X messenger ribonucleoprotein 1

1

7

High-throughput

0.457

High

1454828

NRX2A
Neurexin-2

1

15

Small-scale

0.457

High

1461484

NRX1A
Neurexin-1

1

15

Small-scale

0.457

High

1462487

CD2AP
CD2-associated protein

1

17

High-throughput

0.457

High

62613

S35F4
Solute carrier family 35 member F4

1

5

High-throughput

0.445

High

183983

S22A2
Solute carrier family 22 member 2

1

1

High-throughput

0.445

High

404960

PRIO
Major prion protein

1

1

High-throughput

0.445

High

942960

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

19

High-throughput

0.445

High

1292306

S2611
Sodium-independent sulfate anion transporter

1

2

High-throughput

0.445

High

1340206

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

4

High-throughput

0.445

High

1415100

KTNB1
Katanin p80 WD40 repeat-containing subunit B1

1

14

High-throughput

0.445

High

1420771

ZDHC5
Palmitoyltransferase ZDHHC5

1

4

High-throughput

0.445

High

1428268

S6A16
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

1

4

High-throughput

0.445

High

1434567

VIAAT
Vesicular inhibitory amino acid transporter

1

1

High-throughput

0.445

High

1210134

SNP47
Synaptosomal-associated protein 47

1

0

Small-scale

0.438

High

353630

AGR2
Anterior gradient protein 2 homolog

1

9

High-throughput

0.437

High

590038

RFA2
Replication protein A 32 kDa subunit

1

11

High-throughput

0.437

High

696869

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.437

High

769520

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.437

High

887339

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

Small-scale

0.437

High

965333

WDR5
WD repeat-containing protein 5

1

14

High-throughput

0.437

High

971293

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

8

High-throughput

0.437

High

1142023

EEA1
Early endosome antigen 1

1

20

High-throughput

0.437

High

1150023

TERF2
Telomeric repeat-binding factor 2

1

10

High-throughput

0.437

High

1241985

FBX42
F-box only protein 42

1

4

High-throughput

0.437

High

1289722

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.437

High

1333371

NHLC2
NHL repeat-containing protein 2

1

2

High-throughput

0.437

High

1352401

RHBL4
Rhomboid-related protein 4

1

3

Small-scale

0.437

High

1367596

ESR2
Estrogen receptor beta

1

20

High-throughput

0.437

High

1369586

ATOH1
Transcription factor ATOH1

1

10

Small-scale

0.437

High

1459013

DAXX
Death domain-associated protein 6

1

1

High-throughput

0.437

High

1462486

NGN3
Neurogenin-3

1

11

Small-scale

0.437

High

947080

DSCR9
Down syndrome critical region protein 9

1

3

High-throughput

0.417

High

1250477

MCAF1
Activating transcription factor 7-interacting protein 1

1

11

High-throughput

0.417

High

766010

BMI1
Polycomb complex protein BMI-1

1

20

High-throughput

0.407

High

1231388

AMERL
AMMECR1-like protein

3

0

High-throughput

0.347

High

1395315

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

711680

3MG
DNA-3-methyladenine glycosylase

1

0

High-throughput

0.249

Low

1253017

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low

1332276

TOPZ1
Protein TOPAZ1

1

0

High-throughput

0.249

Low

1361039

P66B
Transcriptional repressor p66-beta

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025