HitPredict

Interactor 1: SFPQ (P23246)
Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor)
Gene: SFPQ

Interactor 2: LARP7 (Q4G0J3)
La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)
Gene: LARP7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29845934
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	NOPS~RRM_1, La~RRM_1, RRM_1~RRM_1
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol and 2 others more... GO:0006397 - mRNA processing GO:0008380 - RNA splicing
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 707 Hs			1 582
+	Hs
		1031352 PABP4_HUMAN (287-694): 8.34e-83: 277: 17.38		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		1116304 PAP1L_HUMAN (287-675): 3.88e-71: 244: 16.33		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		516541 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		403212 PABP4_HUMAN (287-694): 8.34e-83: 277: 17.38		LA_HUMAN (24-365): 5.96e-44: 163: 18.83
+	Hs
		516495 PABP4_HUMAN (287-694): 8.34e-83: 277: 17.38		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Hs
		1031407 PABP4_HUMAN (287-694): 8.34e-83: 277: 17.38		LAR4B_HUMAN (2-216): 8.48e-36: 145: 17.02
+	Hs
		474021 PABP4_HUMAN (287-694): 8.34e-83: 277: 17.38		PAB4L_HUMAN (1-203): 9.24e-35: 136: 11.85
+	Hs
		516689 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		PABP3_HUMAN (1-333): 6.27e-42: 162: 10.11
+	Hs
		516339 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Hs
		516568 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		LARP4_HUMAN (22-216): 3.23e-40: 157: 21.32
+	Hs
		516616 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		LAR4B_HUMAN (2-216): 8.48e-36: 145: 17.02
+	Hs
		1119141 PAP1L_HUMAN (287-675): 3.88e-71: 244: 16.33		PABP5_HUMAN (12-206): 7.64e-32: 128: 14.15
+	Hs
		516635 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		PABP5_HUMAN (12-206): 7.64e-32: 128: 14.15
+	Hs
		1031367 PABP4_HUMAN (287-694): 8.34e-83: 277: 17.38		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23
+	Mm
		665745 PABP1_MOUSE (287-700): 2.49e-70: 243: 16.67		TIA1_MOUSE (120-325): 5.06e-24: 106: 13.94
+	Hs
		1031344 PABP4_HUMAN (287-694): 8.34e-83: 277: 17.38		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50
+	Hs
		613470 SFPQ_HUMAN (1-707): 4.51e-74: 255: 100.00		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50
+	Hs
		516561 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23