HitPredict

Interactor 1: CNOT1 (A5YKK6)
CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1)
Gene: CNOT1

Interactor 2: NANO1 (Q8WY41)
Nanos homolog 1 (NOS-1) (EC_Rep1a)
Gene: NANOS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.649

Property	Details
Experiments	24736845, 33961781
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0017148 - negative regulation of translation GO:1900153 - positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 2376 Hs			1 292
+	Hs
		61338 CNOT1_HUMAN (1-2376): 0: 3468: 100.00		NANO3_HUMAN (175-268): 1.73e-40: 140: 39.36
+	Hs
		61337 CNOT1_HUMAN (1-2376): 0: 3468: 100.00		NANO2_HUMAN (182-268): 3.66e-33: 120: 42.53
+	Mm
		888510 CNOT1_MOUSE (1-2376): 0: 3460: 99.16		NANO2_MOUSE (182-268): 5.37e-34: 122: 44.83
+	Dm
		91055 E2QCN4_DROME (1-2353): 0: 2855: 46.00		NANOS_DROME (211-266): 1.35e-24: 103: 58.93