Protein: S10A6
Protein S100-A6 (Calcyclin) (Growth factor-inducible protein 2A9) (MLN 4) (Prolactin receptor-associated protein) (PRA) (S100 calcium-binding protein A6)

Gene: S10A6, S100A6
Organism: Homo sapiens
Interactions: 232
UniProt ID: P06703

Gene Ontology (top 5):
GO:0001726 - ruffle
GO:0005509 - calcium ion binding
GO:0005523 - tropomyosin binding
GO:0005576 - extracellular region
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

445262

CYBP
Calcyclin-binding protein

6

7

Small-scale

0.946

High

407562

S100B
Protein S100-B

3

17

Small-scale

0.880

High

413018

P53
Cellular tumor antigen p53

3

15

Small-scale

0.845

High

445107

S10A6
Protein S100-A6

2

19

Small-scale

0.726

High

445293

SGT1
Protein SGT1 homolog

1

2

Small-scale

0.724

High

445129

S10A4
Protein S100-A4

1

19

High-throughput

0.691

High

445282

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

1

6

High-throughput

0.691

High

445149

ANX11
Annexin A11

1

12

Small-scale

0.647

High

445165

MDM2
E3 ubiquitin-protein ligase Mdm2

2

9

Small-scale

0.646

High

289912

OFD1
Centriole and centriolar satellite protein OFD1

2

1

Small-scale

0.619

High

445184

CTF1
Cardiotrophin-1

2

5

Small-scale

0.619

High

445167

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

10

Small-scale

0.597

High

445157

UFM1
Ubiquitin-fold modifier 1

2

0

High-throughput

0.585

High

352847

AGR2
Anterior gradient protein 2 homolog

2

5

Small-scale

0.584

High

341887

CEP43
Centrosomal protein 43

2

0

Small-scale

0.577

High

445148

PEX5
Peroxisomal targeting signal 1 receptor

1

2

High-throughput

0.573

High

445117

NDKA
Nucleoside diphosphate kinase A

2

2

High-throughput

0.571

High

445131

SHC1
SHC-transforming protein 1

2

16

High-throughput

0.571

High

445133

PEBP1
Phosphatidylethanolamine-binding protein 1

2

3

High-throughput

0.571

High

445248

SH3G3
Endophilin-A3

2

6

High-throughput

0.571

High

445150

IMA1
Importin subunit alpha-1

1

1

Small-scale

0.561

High

445170

PPID
Peptidyl-prolyl cis-trans isomerase D

1

5

Small-scale

0.561

High

445162

HTRA4
Serine protease HTRA4

1

9

High-throughput

0.554

High

61400

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.536

High

209439

SERA
D-3-phosphoglycerate dehydrogenase

1

2

High-throughput

0.536

High

245405

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

2

High-throughput

0.536

High

258542

DIAP2
Protein diaphanous homolog 2

1

3

High-throughput

0.536

High

274077

ANR17
Ankyrin repeat domain-containing protein 17

1

1

High-throughput

0.536

High

281707

VP26A
Vacuolar protein sorting-associated protein 26A

1

1

High-throughput

0.536

High

286321

ZN821
Zinc finger protein 821

1

5

High-throughput

0.536

High

291893

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

4

High-throughput

0.536

High

292327

RA51D
DNA repair protein RAD51 homolog 4

1

2

High-throughput

0.536

High

298566

RAD17
Cell cycle checkpoint protein RAD17

1

1

High-throughput

0.536

High

319301

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.536

High

340281

YETS4
YEATS domain-containing protein 4

1

1

High-throughput

0.536

High

352054

MBD3
Methyl-CpG-binding domain protein 3

1

1

High-throughput

0.536

High

445112

TAU
Microtubule-associated protein tau

1

15

High-throughput

0.536

High

445119

PRS6A
26S proteasome regulatory subunit 6A

1

4

High-throughput

0.536

High

445147

RBP2
E3 SUMO-protein ligase RanBP2

1

4

High-throughput

0.536

High

445151

ALR
FAD-linked sulfhydryl oxidase ALR

1

3

High-throughput

0.536

High

445152

UCP2
Dicarboxylate carrier SLC25A8

1

5

High-throughput

0.536

High

445164

HSF1
Heat shock factor protein 1

1

5

High-throughput

0.536

High

445166

CDR2
Cerebellar degeneration-related protein 2

1

2

High-throughput

0.536

High

445168

HSF2
Heat shock factor protein 2

1

5

High-throughput

0.536

High

445169

SPAG1
Sperm-associated antigen 1

1

2

High-throughput

0.536

High

445175

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

1

High-throughput

0.536

High

445176

PEX6
Peroxisomal ATPase PEX6

1

4

High-throughput

0.536

High

445182

STXB2
Syntaxin-binding protein 2

1

1

High-throughput

0.536

High

445186

LONF2
LON peptidase N-terminal domain and RING finger protein 2

1

3

High-throughput

0.536

High

445187

INF2
Inverted formin-2

1

3

High-throughput

0.536

High

445190

GRDN
Girdin

1

20

High-throughput

0.536

High

445191

CCD14
Coiled-coil domain-containing protein 14

1

3

High-throughput

0.536

High

445192

VP26B
Vacuolar protein sorting-associated protein 26B

1

1

High-throughput

0.536

High

445193

GRAP1
GRIP1-associated protein 1

1

15

High-throughput

0.536

High

445194

GLE1
mRNA export factor GLE1

1

3

High-throughput

0.536

High

445200

ECM29
Proteasome adapter and scaffold protein ECM29

1

2

High-throughput

0.536

High

445204

DEN1B
DENN domain-containing protein 1B

1

2

High-throughput

0.536

High

445205

PKN3
Serine/threonine-protein kinase N3

1

7

High-throughput

0.536

High

445210

DPH6
Diphthine--ammonia ligase

1

1

High-throughput

0.536

High

445211

LIPB1
Liprin-beta-1

1

18

High-throughput

0.536

High

445212

KI18B
Kinesin-like protein KIF18B

1

8

High-throughput

0.536

High

445214

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

1

High-throughput

0.536

High

445215

SPICE
Spindle and centriole-associated protein 1

1

1

High-throughput

0.536

High

445218

KDM1B
Lysine-specific histone demethylase 2

1

1

High-throughput

0.536

High

445219

SPC24
Kinetochore protein Spc24

1

3

High-throughput

0.536

High

445222

NEDD1
Protein NEDD1

1

1

High-throughput

0.536

High

445225

GEMI5
Gem-associated protein 5

1

2

High-throughput

0.536

High

445226

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

3

High-throughput

0.536

High

445230

SYMPK
Symplekin

1

1

High-throughput

0.536

High

445234

HAUS1
HAUS augmin-like complex subunit 1

1

3

High-throughput

0.536

High

445235

RMD1
Regulator of microtubule dynamics protein 1

1

1

High-throughput

0.536

High

445236

TRI11
E3 ubiquitin-protein ligase TRIM11

1

10

High-throughput

0.536

High

445239

BOD1
Biorientation of chromosomes in cell division protein 1

1

1

High-throughput

0.536

High

445241

TOX2
TOX high mobility group box family member 2

1

6

High-throughput

0.536

High

445242

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

4

High-throughput

0.536

High

445243

PUS7
Pseudouridylate synthase 7 homolog

1

2

High-throughput

0.536

High

445246

CK5P2
CDK5 regulatory subunit-associated protein 2

1

20

High-throughput

0.536

High

445247

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

1

2

High-throughput

0.536

High

445252

CC28B
Coiled-coil domain-containing protein 28B

1

4

High-throughput

0.536

High

445253

KATL1
Katanin p60 ATPase-containing subunit A-like 1

1

5

High-throughput

0.536

High

445254

SSBP3
Single-stranded DNA-binding protein 3

1

1

High-throughput

0.536

High

445256

MIS12
Protein MIS12 homolog

1

2

High-throughput

0.536

High

445257

KLC2
Kinesin light chain 2

1

10

High-throughput

0.536

High

445258

DSN1
Kinetochore-associated protein DSN1 homolog

1

2

High-throughput

0.536

High

445264

SPC25
Kinetochore protein Spc25

1

3

High-throughput

0.536

High

445265

CWC22
Pre-mRNA-splicing factor CWC22 homolog

1

1

High-throughput

0.536

High

445268

SALL1
Sal-like protein 1

1

7

High-throughput

0.536

High

445271

GNL3L
Guanine nucleotide-binding protein-like 3-like protein

1

1

High-throughput

0.536

High

445272

ING3
Inhibitor of growth protein 3

1

1

High-throughput

0.536

High

445275

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

1

4

High-throughput

0.536

High

445276

STK26
Serine/threonine-protein kinase 26

1

10

High-throughput

0.536

High

445279

PI4KB
Phosphatidylinositol 4-kinase beta

1

4

High-throughput

0.536

High

445284

TBK1
Serine/threonine-protein kinase TBK1

1

8

High-throughput

0.536

High

445285

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

1

High-throughput

0.536

High

445286

INT6
Integrator complex subunit 6

1

6

High-throughput

0.536

High

445290

DYN3
Dynamin-3

1

2

High-throughput

0.536

High

445292

EFR3B
Protein EFR3 homolog B

1

2

High-throughput

0.536

High

445294

PHOCN
MOB-like protein phocein

1

2

High-throughput

0.536

High

445295

STK24
Serine/threonine-protein kinase 24

1

10

High-throughput

0.536

High

445110

PARP1
Poly [ADP-ribose] polymerase 1

1

4

High-throughput

0.515

High

128369

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

0

High-throughput

0.513

High

220557

AKA10
A-kinase anchor protein 10, mitochondrial

1

0

High-throughput

0.513

High

273153

CAND2
Cullin-associated NEDD8-dissociated protein 2

1

0

High-throughput

0.513

High

317433

GFPT2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

1

0

High-throughput

0.513

High

340605

STABP
STAM-binding protein

1

0

High-throughput

0.513

High

445108

ERCC1
DNA excision repair protein ERCC-1

1

0

High-throughput

0.513

High

445120

NELFE
Negative elongation factor E

1

0

High-throughput

0.513

High

445121

DNLI1
DNA ligase 1

1

0

High-throughput

0.513

High

445125

KTHY
Thymidylate kinase

1

0

High-throughput

0.513

High

445145

INPP
Inositol polyphosphate 1-phosphatase

1

0

High-throughput

0.513

High

445158

PRS10
26S proteasome regulatory subunit 10B

1

0

High-throughput

0.513

High

445178

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

1

0

High-throughput

0.513

High

445181

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

High-throughput

0.513

High

445185

UGPA
UTP--glucose-1-phosphate uridylyltransferase

1

0

High-throughput

0.513

High

445189

CTU2
Cytoplasmic tRNA 2-thiolation protein 2

1

0

High-throughput

0.513

High

445198

STXB5
Syntaxin-binding protein 5

1

0

High-throughput

0.513

High

445206

INT5
Integrator complex subunit 5

1

0

High-throughput

0.513

High

445209

INT8
Integrator complex subunit 8

1

0

High-throughput

0.513

High

445213

TPPC5
Trafficking protein particle complex subunit 5

1

0

High-throughput

0.513

High

445227

CKAP2
Cytoskeleton-associated protein 2

1

0

High-throughput

0.513

High

445228

NELFB
Negative elongation factor B

1

0

High-throughput

0.513

High

445231

SKA1
SKA complex subunit 1

1

0

High-throughput

0.513

High

445237

CDA7L
Cell division cycle-associated 7-like protein

1

0

High-throughput

0.513

High

445244

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.513

High

445249

SIKE1
Suppressor of IKBKE 1

1

0

High-throughput

0.513

High

445250

TBCD
Tubulin-specific chaperone D

1

0

High-throughput

0.513

High

445259

OSBL3
Oxysterol-binding protein-related protein 3

1

0

High-throughput

0.513

High

445261

B2L12
Bcl-2-like protein 12

1

0

High-throughput

0.513

High

445270

EXOC1
Exocyst complex component 1

1

0

High-throughput

0.513

High

445288

EXOC7
Exocyst complex component 7

1

0

High-throughput

0.513

High

445296

EPN1
Epsin-1

1

0

High-throughput

0.513

High

377144

PRL
Prolactin

1

5

Small-scale

0.501

High

377155

SOMA
Somatotropin

1

5

Small-scale

0.501

High

377238

SOM2
Growth hormone variant

1

5

Small-scale

0.501

High

378353

IFNB
Interferon beta

1

6

Small-scale

0.501

High

378587

EPO
Erythropoietin

1

2

Small-scale

0.501

High

403266

CSF2
Granulocyte-macrophage colony-stimulating factor

1

1

Small-scale

0.501

High

424327

IL5
Interleukin-5

1

1

Small-scale

0.501

High

445109

IL3
Interleukin-3

1

1

Small-scale

0.501

High

445111

CSF3
Granulocyte colony-stimulating factor

1

1

Small-scale

0.501

High

445115

IL9
Interleukin-9

1

1

Small-scale

0.501

High

445122

IL11
Interleukin-11

1

3

Small-scale

0.501

High

445124

IL10
Interleukin-10

1

1

Small-scale

0.501

High

445128

CNTF
Ciliary neurotrophic factor

1

2

Small-scale

0.501

High

445132

IL12A
Interleukin-12 subunit alpha

1

1

Small-scale

0.501

High

445135

NAC1
Sodium/calcium exchanger 1

1

18

Small-scale

0.501

High

445137

IL13
Interleukin-13

1

1

Small-scale

0.501

High

445139

MYH9
Myosin-9

1

15

Small-scale

0.501

High

445140

TPO
Thrombopoietin

1

1

Small-scale

0.501

High

445141

IL15
Interleukin-15

1

1

Small-scale

0.501

High

445142

LEP
Leptin

1

1

Small-scale

0.501

High

445171

IL24
Interleukin-24

1

6

Small-scale

0.501

High

445177

IL27B
Interleukin-27 subunit beta

1

2

Small-scale

0.501

High

445180

KS6A1
Ribosomal protein S6 kinase alpha-1

1

10

Small-scale

0.501

High

445202

IL31
Interleukin-31

1

1

Small-scale

0.501

High

445220

IL27A
Interleukin-27 subunit alpha

1

1

Small-scale

0.501

High

445224

TRPM4
Transient receptor potential cation channel subfamily M member 4

1

12

Small-scale

0.501

High

445240

CEP20
Centrosomal protein 20

1

5

Small-scale

0.501

High

445255

IL22
Interleukin-22

1

1

Small-scale

0.501

High

445263

IL21
Interleukin-21

1

1

Small-scale

0.501

High

445266

IL26
Interleukin-26

1

1

Small-scale

0.501

High

445274

IL20
Interleukin-20

1

6

Small-scale

0.501

High

445278

CLCF1
Cardiotrophin-like cytokine factor 1

1

5

Small-scale

0.501

High

445283

IL19
Interleukin-19

1

6

Small-scale

0.501

High

445289

TBD2B
TBC1 domain family member 2B

1

0

High-throughput

0.493

High

445195

INT6L
Integrator complex subunit 6-like

1

6

High-throughput

0.489

High

445199

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

5

High-throughput

0.489

High

445201

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

1

10

High-throughput

0.489

High

445208

CE128
Centrosomal protein of 128 kDa

1

20

High-throughput

0.489

High

445221

ABHDB
sn-1-specific diacylglycerol lipase ABHD11

1

3

High-throughput

0.489

High

445223

PPTC7
Protein phosphatase PTC7 homolog

1

3

High-throughput

0.489

High

445238

FMC1
Protein FMC1 homolog

1

1

High-throughput

0.489

High

445273

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

1

1

High-throughput

0.489

High

445123

SCF
Kit ligand

1

0

Small-scale

0.480

High

445146

FLT3L
Fms-related tyrosine kinase 3 ligand

1

0

Small-scale

0.480

High

445156

IL2
Interleukin-2

1

0

Small-scale

0.480

High

247212

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

5

High-throughput

0.479

High

259307

BRD4
Bromodomain-containing protein 4

1

5

High-throughput

0.479

High

293065

CD123
Translation initiation factor eIF2 assembly protein

1

9

High-throughput

0.479

High

370933

MYC
Myc proto-oncogene protein

1

13

High-throughput

0.479

High

377915

TNFA
Tumor necrosis factor

1

5

High-throughput

0.479

High

436764

K1C18
Keratin, type I cytoskeletal 18

1

5

High-throughput

0.479

High

445118

CEBPB
CCAAT/enhancer-binding protein beta

1

9

High-throughput

0.479

High

445126

CDK2
Cyclin-dependent kinase 2

1

10

High-throughput

0.479

High

445127

U2AF2
Splicing factor U2AF 65 kDa subunit

1

1

High-throughput

0.479

High

445130

CALX
Calnexin

1

1

High-throughput

0.479

High

445136

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

5

High-throughput

0.479

High

445143

TISD
mRNA decay activator protein ZFP36L2

1

1

High-throughput

0.479

High

445144

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

5

High-throughput

0.479

High

445153

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

7

High-throughput

0.479

High

445160

1433Z
14-3-3 protein zeta/delta

1

2

High-throughput

0.479

High

445172

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

8

High-throughput

0.479

High

445174

SQSTM
Sequestosome-1

1

3

High-throughput

0.479

High

445183

EZH2
Histone-lysine N-methyltransferase EZH2

1

6

High-throughput

0.479

High

445207

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

445217

ARFG2
ADP-ribosylation factor GTPase-activating protein 2

1

1

High-throughput

0.479

High

445232

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

445233

CHM4C
Charged multivesicular body protein 4c

1

6

High-throughput

0.479

High

445245

RANB9
Ran-binding protein 9

1

4

High-throughput

0.479

High

445280

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

4

High-throughput

0.479

High

445281

HDAC6
Protein deacetylase HDAC6

1

8

High-throughput

0.479

High

445287

CHIP
E3 ubiquitin-protein ligase CHIP

1

4

Small-scale

0.479

High

445291

FBW1A
F-box/WD repeat-containing protein 1A

1

6

High-throughput

0.479

High

75145

FM25C
Protein FAM25C

1

1

High-throughput

0.470

High

215379

TPD54
Tumor protein D54

1

0

Small-scale

0.458

High

295277

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.458

High

445113

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.458

High

445116

FOLR1
Folate receptor alpha

1

0

High-throughput

0.458

High

445134

CCND2
G1/S-specific cyclin-D2

1

0

Small-scale

0.458

High

445161

H31
Histone H3.1

1

0

High-throughput

0.458

High

445179

SMC1A
Structural maintenance of chromosomes protein 1A

1

0

High-throughput

0.458

High

420228

IFNW1
Interferon omega-1

1

6

Small-scale

0.457

High

445114

CFTR
Cystic fibrosis transmembrane conductance regulator

1

8

High-throughput

0.445

High

445138

BMI1
Polycomb complex protein BMI-1

1

20

High-throughput

0.445

High

445155

CD81
CD81 antigen

1

7

High-throughput

0.445

High

445159

GRB2
Growth factor receptor-bound protein 2

1

4

High-throughput

0.445

High

445173

CTBP1
C-terminal-binding protein 1

1

2

High-throughput

0.445

High

75126

FM25A
Protein FAM25A

1

1

High-throughput

0.439

High

445267

MANBL
Protein MANBAL

2

0

High-throughput

0.328

High

445251

CHCH7
Coiled-coil-helix-coiled-coil-helix domain-containing protein 7

2

0

High-throughput

0.319

High

445154

AP3S2
AP-3 complex subunit sigma-2

1

0

High-throughput

0.279

Low

445163

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.279

Low

445188

ATG2A
Autophagy-related protein 2 homolog A

1

0

High-throughput

0.279

Low

445197

SYRM
Probable arginine--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

445203

PTRD1
Putative peptidyl-tRNA hydrolase PTRHD1

1

0

High-throughput

0.279

Low

445216

RIBC1
RIB43A-like with coiled-coils protein 1

1

0

High-throughput

0.279

Low

445229

TM9S4
Transmembrane 9 superfamily member 4

1

0

High-throughput

0.279

Low

445260

F204A
Protein FAM204A

1

0

High-throughput

0.279

Low

445269

ABCF3
ATP-binding cassette sub-family F member 3

1

0

High-throughput

0.279

Low

445277

STX18
Syntaxin-18

1

0

High-throughput

0.279

Low

445196

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025