Interactor 1: PACA (P18509)
Pituitary adenylate cyclase-activating polypeptide (PACAP) [Cleaved into: PACAP-related peptide (PRP-48); Pituitary adenylate cyclase-activating polypeptide 27 (PACAP-27) (PACAP27); Pituitary adenylate cyclase-activating polypeptide 38 (PACAP-38) (PACAP38)]
Gene: ADCYAP1
Interactor 2: PACR (P41586)
Pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1 receptor) (PAC1R) (PACAP type I receptor) (PACAP-R-1) (PACAP-R1)
Gene: ADCYAP1R1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.47 | 1.00 | 0.692 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 17470806 |
| Identification Methods | fluorescence polarization spectroscopy, nuclear magnetic resonance |
| Interaction Type | direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | 7tm_2~Hormone_2, HRM~Hormone_2 |
| Common GO terms | GO:0007188 - adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007189 - adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| Homologous interactions | 2 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
