Protein: PACA
Pituitary adenylate cyclase-activating polypeptide (PACAP) [Cleaved into: PACAP-related peptide (PRP-48); Pituitary adenylate cyclase-activating polypeptide 27 (PACAP-27) (PACAP27); Pituitary adenylate cyclase-activating polypeptide 38 (PACAP-38) (PACAP38)]

Gene: PACA, ADCYAP1
Organism: Homo sapiens
Interactions: 45
UniProt ID: P18509

Gene Ontology (top 5):
GO:0005102 - signaling receptor binding
GO:0005184 - neuropeptide hormone activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0007188 - adenylate cyclase-modulating G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

615171

PACR
Pituitary adenylate cyclase-activating polypeptide type I receptor

1

2

Small-scale

0.692

High

615177

NUCB1
Nucleobindin-1

3

0

High-throughput

0.638

High

615202

PCS1N
ProSAAS

3

0

High-throughput

0.638

High

615179

STK4
Serine/threonine-protein kinase 4

4

1

High-throughput

0.630

High

615180

STK3
Serine/threonine-protein kinase 3

4

1

High-throughput

0.630

High

615191

PXDN
Peroxidasin homolog

2

1

High-throughput

0.611

High

615186

ARMC8
Armadillo repeat-containing protein 8

2

0

High-throughput

0.576

High

615175

YPEL5
Protein yippee-like 5

2

0

High-throughput

0.547

High

615172

SCTR
Secretin receptor

1

2

Small-scale

0.527

High

615201

GID8
Glucose-induced degradation protein 8 homolog

2

4

High-throughput

0.521

High

615203

MKLN1
Muskelin

2

2

High-throughput

0.521

High

421464

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.515

High

615192

APBB2
Amyloid beta precursor protein binding family B member 2

1

0

High-throughput

0.513

High

533585

CLUS
Clusterin

1

0

Small-scale

0.484

High

183846

VGF
Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1

1

1

High-throughput

0.445

High

615170

DPP4
Dipeptidyl peptidase 4

1

3

Small-scale

0.445

High

615176

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

1

1

High-throughput

0.445

High

615178

SEPR
Prolyl endopeptidase FAP

1

3

Small-scale

0.445

High

271883

OBSL1
Obscurin-like protein 1

1

1

High-throughput

0.437

High

66578

CC85C
Coiled-coil domain-containing protein 85C

1

1

High-throughput

0.407

High

615181

CC85B
Coiled-coil domain-containing protein 85B

1

1

High-throughput

0.407

High

615183

RBP10
Ran-binding protein 10

1

2

High-throughput

0.407

High

615184

MAEA
E3 ubiquitin-protein transferase MAEA

1

4

High-throughput

0.407

High

615185

PRIC2
Prickle-like protein 2

1

1

High-throughput

0.407

High

615193

PRIC1
Prickle-like protein 1

1

1

High-throughput

0.407

High

615194

RANB9
Ran-binding protein 9

1

2

High-throughput

0.407

High

615199

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

3

High-throughput

0.407

High

615190

CPMD8
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8

1

0

Small-scale

0.391

High

615196

SAV1
Protein salvador homolog 1

4

0

High-throughput

0.360

High

607684

DCAM
S-adenosylmethionine decarboxylase proenzyme

3

0

High-throughput

0.347

High

615173

ICLN
Methylosome subunit pICln

3

0

High-throughput

0.347

High

615188

GCC2
GRIP and coiled-coil domain-containing protein 2

3

0

High-throughput

0.347

High

615204

T10B
Mitochondrial import inner membrane translocase subunit Tim10 B

3

0

High-throughput

0.347

High

343672

GGPPS
Geranylgeranyl pyrophosphate synthase

2

0

High-throughput

0.328

High

615182

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

2

0

High-throughput

0.328

High

181608

CETN3
Centrin-3

2

0

High-throughput

0.318

High

615195

CSN8
COP9 signalosome complex subunit 8

2

0

High-throughput

0.318

High

615200

COPRS
Coordinator of PRMT5 and differentiation stimulator

2

0

High-throughput

0.318

High

563158

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.282

High

554771

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

615174

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

1

0

High-throughput

0.279

Low

615187

GID4
Glucose-induced degradation protein 4 homolog

1

0

High-throughput

0.249

Low

615189

P20D2
Xaa-Arg dipeptidase

1

0

High-throughput

0.249

Low

615197

OSBL3
Oxysterol-binding protein-related protein 3

1

0

High-throughput

0.249

Low

615198

WDR26
WD repeat-containing protein 26

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025