HitPredict

Interactor 1: S10A1 (P23297)
Protein S100-A1 (S-100 protein alpha chain) (S-100 protein subunit alpha) (S100 calcium-binding protein A1)
Gene: S100A1

Interactor 2: KS6A1 (Q15418)
Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1)
Gene: RPS6KA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	31837246
Identification Methods	fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	EF-hand_1~Pkinase
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0035556 - intracellular signal transduction
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 94 Hs			1 735
+	Hs
		638962 S100P_HUMAN (3-92): 3.73e-33: 111: 54.44		KS6A1_HUMAN (1-735): 0: 836: 100.00
+	Hs
		642947 S10A4_HUMAN (1-90): 5.06e-32: 109: 51.11		KS6A1_HUMAN (1-735): 0: 836: 100.00
+	Hs
		661265 S10A2_HUMAN (1-90): 1.74e-31: 107: 52.22		KS6A1_HUMAN (1-735): 0: 836: 100.00
+	Hs
		380782 S100B_HUMAN (3-93): 1.37e-29: 102: 58.24		KS6A1_HUMAN (1-735): 0: 836: 100.00
+	Hs
		416623 S10A6_HUMAN (1-88): 1.92e-26: 94.5: 44.32		KS6A1_HUMAN (1-735): 0: 836: 100.00
+	Hs
		682050 CRNN_HUMAN (1-94): 8.37e-31: 114: 31.92		AKT1_HUMAN (411-724): 3.69e-122: 375: 25.92
+	Hs
		707403 S10A3_HUMAN (1-90): 4.12e-30: 104: 42.22		AKT3_HUMAN (358-719): 9.26e-123: 377: 21.87
+	Hs
		681685 S10A3_HUMAN (1-90): 4.12e-30: 104: 42.22		AKT1_HUMAN (411-724): 3.69e-122: 375: 25.92
+	Hs
		682028 S10AE_HUMAN (3-84): 7.93e-20: 78.3: 26.83		AKT1_HUMAN (411-724): 3.69e-122: 375: 25.92
+	Hs
		380732 S100B_HUMAN (3-93): 1.37e-29: 102: 58.24		KAPCA_HUMAN (414-712): 3.66e-114: 350: 29.71