Protein: I36RA
Interleukin-36 receptor antagonist protein (IL-36Ra) (FIL1 delta) (IL-1-related protein 3) (IL-1RP3) (Interleukin-1 HY1) (IL-1HY1) (Interleukin-1 delta) (IL-1 delta) (Interleukin-1 family member 5) (IL-1F5) (Interleukin-1 receptor antagonist homolog 1) (IL-1ra homolog 1) (Interleukin-1-like protein 1) (IL-1L1)

Gene: I36RA, IL36RN
Organism: Homo sapiens
Interactions: 49
UniProt ID: Q9UBH0

Gene Ontology (top 5):
GO:0001960 - negative regulation of cytokine-mediated signaling pathway
GO:0005125 - cytokine activity
GO:0005149 - interleukin-1 receptor binding
GO:0005152 - interleukin-1 receptor antagonist activity
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1049038

REL
Proto-oncogene c-Rel

3

6

High-throughput

0.675

High

1010788

SSBP2
Single-stranded DNA-binding protein 2

2

4

High-throughput

0.633

High

557504

SRC
Proto-oncogene tyrosine-protein kinase Src

2

2

High-throughput

0.628

High

1400520

CDK15
Cyclin-dependent kinase 15

2

2

High-throughput

0.628

High

1416431

SSBP3
Single-stranded DNA-binding protein 3

3

4

High-throughput

0.616

High

1416159

SSBP4
Single-stranded DNA-binding protein 4

3

4

High-throughput

0.609

High

154444

SH2B2
SH2B adapter protein 2

2

3

High-throughput

0.606

High

1330538

UBL4B
Ubiquitin-like protein 4B

2

1

High-throughput

0.606

High

507399

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

0

High-throughput

0.602

High

353604

AGR2
Anterior gradient protein 2 homolog

2

0

High-throughput

0.580

High

1014870

HPCA
Neuron-specific calcium-binding protein hippocalcin

2

0

High-throughput

0.580

High

1081507

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

1386898

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.580

High

1451574

IRAK4
Interleukin-1 receptor-associated kinase 4

2

0

High-throughput

0.580

High

1449689

TB22B
TBC1 domain family member 22B

2

1

High-throughput

0.574

High

1380365

ZKSC4
Zinc finger protein with KRAB and SCAN domains 4

2

1

High-throughput

0.553

High

602844

AATC
Aspartate aminotransferase, cytoplasmic

1

3

High-throughput

0.536

High

733453

CCR1
C-C chemokine receptor type 1

1

3

High-throughput

0.536

High

1448000

MBNL1
Muscleblind-like protein 1

1

2

High-throughput

0.536

High

1458399

SSUH2
Protein SSUH2 homolog

1

3

High-throughput

0.536

High

1458401

RN115
E3 ubiquitin-protein ligase RNF115

1

2

High-throughput

0.536

High

1458398

DD19B
ATP-dependent RNA helicase DDX19B

1

0

High-throughput

0.513

High

1128302

MCM6
DNA replication licensing factor MCM6

1

1

High-throughput

0.494

High

325361

OR2A4
Olfactory receptor 2A4

1

3

High-throughput

0.489

High

943148

STX17
Syntaxin-17

1

2

High-throughput

0.489

High

1023904

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

3

High-throughput

0.489

High

1181349

CR021
UPF0711 protein C18orf21

1

2

High-throughput

0.489

High

1292353

ZC3C1
Zinc finger C3HC-type protein 1

1

1

High-throughput

0.489

High

1306988

CERS3
Ceramide synthase 3

1

2

High-throughput

0.489

High

1380553

PIGT
GPI-anchor transamidase component PIGT

1

2

High-throughput

0.489

High

1385212

SARAF
Store-operated calcium entry-associated regulatory factor

1

2

High-throughput

0.489

High

1408246

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

3

High-throughput

0.489

High

1458397

PHF11
PHD finger protein 11

1

2

High-throughput

0.489

High

555528

SKIL
Ski-like protein

1

0

High-throughput

0.486

High

1014642

SMAD3
Mothers against decapentaplegic homolog 3

1

1

Small-scale

0.445

High

1404066

MYCBP
c-Myc-binding protein

1

1

High-throughput

0.445

High

261303

NSMA
Sphingomyelin phosphodiesterase 2

1

2

High-throughput

0.407

High

1227623

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.407

High

520715

RRAS
Ras-related protein R-Ras

2

0

High-throughput

0.328

High

1411458

SRSF8
Serine/arginine-rich splicing factor 8

2

0

High-throughput

0.328

High

340591

CNOT4
CCR4-NOT transcription complex subunit 4

2

0

High-throughput

0.316

High

1327016

EFC4A
EF-hand calcium-binding domain-containing protein 4A

2

0

High-throughput

0.316

High

1458400

AP3M1
AP-3 complex subunit mu-1

2

0

High-throughput

0.316

High

255260

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.279

Low

1358677

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

1

0

High-throughput

0.279

Low

1448452

PRDC1
Phosphoribosyltransferase domain-containing protein 1

1

0

High-throughput

0.279

Low

1407205

THIOM
Thioredoxin, mitochondrial

1

0

High-throughput

0.269

Low

1396142

Z512B
Zinc finger protein 512B

1

0

High-throughput

0.265

Low

1358213

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025