HitPredict

Interactor 1: CDK2 (P23437)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (CDC2 homolog Eg1 protein kinase) (Cell division protein kinase 2)
Gene: CDK2

Interactor 2: Q91646 (Q91646)
Cyclin-dependent kinase inhibitor p28 (Cyclin-dependent kinase inhibitor xic1 L homeolog) (LOC100137657 protein)
Gene: cdknx.L

Species: Xenopus laevis

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.840

Property	Details
Experiments	12023298, 8868473, 16118210
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	CDI~Pkinase
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 297 Xl			1 209
+	Xl
		1153623 Q6IRQ7_XENLA (1-297): 3.94e-154: 433: 98.32		Q91646_XENLA (1-209): 2.77e-82: 245: 100.00
+	Xl
		724512 CDK1A_XENLA (1-296): 8.24e-140: 398: 64.65		Q91646_XENLA (1-209): 2.77e-82: 245: 100.00
+	Hs
		625207 CDK2_HUMAN (1-296): 1.26e-153: 432: 89.53		CDN1B_HUMAN (21-185): 2.33e-52: 168: 25.00
+	Rn
		139842 CDK2_RAT (1-296): 2.84e-154: 434: 88.51		O08769_RAT (21-185): 9.73e-50: 162: 25.60
+	Hs
		625186 CDK2_HUMAN (1-296): 1.26e-153: 432: 89.53		CDN1A_HUMAN (27-187): 3.46e-48: 157: 21.95
+	Hs
		804104 CDK3_HUMAN (1-294): 5.04e-149: 421: 76.53		CDN1B_HUMAN (21-185): 2.33e-52: 168: 25.00
+	Mm
		763415 CDK2_MOUSE (1-296): 7.55e-145: 412: 76.45		CDN1A_MOUSE (27-187): 1.71e-53: 170: 23.60
+	Hs
		758188 CDK3_HUMAN (1-294): 5.04e-149: 421: 76.53		CDN1A_HUMAN (27-187): 3.46e-48: 157: 21.95
+	Mm
		803840 CDK2_MOUSE (1-296): 7.55e-145: 412: 76.45		CDN1B_MOUSE (21-185): 5.23e-51: 165: 26.19
+	Hs
		414811 CDK1_HUMAN (1-289): 2.44e-140: 399: 65.52		CDN1B_HUMAN (21-185): 2.33e-52: 168: 25.00
+	Mm
		509470 CDK1_MOUSE (1-289): 2.43e-139: 396: 66.21		CDN1A_MOUSE (27-187): 1.71e-53: 170: 23.60
+	Hs
		414796 CDK1_HUMAN (1-289): 2.44e-140: 399: 65.52		CDN1A_HUMAN (27-187): 3.46e-48: 157: 21.95
+	Hs
		804106 CDK5_HUMAN (1-292): 2.67e-136: 388: 60.07		CDN1B_HUMAN (21-185): 2.33e-52: 168: 25.00
+	Dm
		618433 CDK2_DROME (1-289): 6.24e-134: 383: 63.67		P91654_DROME (13-208): 2.14e-50: 165: 20.87
+	Dm
		618434 CDK2_DROME (1-289): 6.24e-134: 383: 63.67		P91668_DROME (11-209): 3.52e-49: 162: 21.53
+	Dm
		618446 CDK2_DROME (1-289): 6.24e-134: 383: 63.67		Q7JNL9_DROME (11-209): 3.3e-49: 162: 21.53
+	Hs
		758190 CDK5_HUMAN (1-292): 2.67e-136: 388: 60.07		CDN1A_HUMAN (27-187): 3.46e-48: 157: 21.95
+	Hs
		625237 CDK2_HUMAN (1-296): 1.26e-153: 432: 89.53		CDN1C_HUMAN (27-137): 4.82e-28: 109: 31.30
+	Hs
		836898 CDK3_HUMAN (1-294): 5.04e-149: 421: 76.53		CDN1C_HUMAN (27-137): 4.82e-28: 109: 31.30
+	Hs
		414825 CDK1_HUMAN (1-289): 2.44e-140: 399: 65.52		CDN1C_HUMAN (27-137): 4.82e-28: 109: 31.30