HitPredict

Interactor 1: JAK1 (P23458)
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
Gene: JAK1

Interactor 2: APJ (P35414)
Apelin receptor (Angiotensin receptor-like 1) (G-protein coupled receptor APJ) (G-protein coupled receptor HG11)
Gene: APLNR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1154 Hs			1 380
+	Hs
		616777 JAK1_HUMAN (1-1154): 0: 1035: 100.00		CXCR4_HUMAN (4-325): 2.98e-79: 249: 27.69
+	Hs
		616861 JAK1_HUMAN (1-1154): 0: 1035: 100.00		CML1_HUMAN (17-376): 8.15e-76: 241: 28.84
+	Hs
		616743 JAK1_HUMAN (1-1154): 0: 1035: 100.00		AGTR1_HUMAN (24-349): 4.62e-65: 212: 31.80
+	Hs
		238391 JAK2_HUMAN (33-1153): 0: 799: 42.14		CXCR4_HUMAN (4-325): 2.98e-79: 249: 27.69
+	Hs
		238386 JAK2_HUMAN (33-1153): 0: 799: 42.14		CCR5_HUMAN (9-353): 1.81e-74: 236: 25.49
+	Hs
		238366 JAK2_HUMAN (33-1153): 0: 799: 42.14		AGTR1_HUMAN (24-349): 4.62e-65: 212: 31.80
+	Rn
		626617 JAK2_RAT (33-1153): 0: 782: 41.54		AGTRA_RAT (1-366): 4.52e-66: 215: 28.34
+	Hs
		428898 SRC_HUMAN (868-1151): 7e-99: 326: 31.23		ADRB2_HUMAN (1-349): 2e-70: 228: 20.47
+	Hs
		846452 BLK_HUMAN (853-1152): 7.51e-90: 300: 28.15		CXCR4_HUMAN (4-325): 2.98e-79: 249: 27.69
+	Rn
		706745 SRC_RAT (868-1151): 1.4e-97: 322: 30.88		OPRM_RAT (6-373): 1.63e-68: 222: 23.85
+	Mm
		403428 SRC_MOUSE (868-1151): 1.36e-97: 322: 30.88		5HT4R_MOUSE (25-378): 9.72e-68: 220: 20.21
+	Hs
		522834 SRC_HUMAN (868-1151): 7e-99: 326: 31.23		CCR2_HUMAN (2-376): 5.15e-64: 210: 23.87
+	Hs
		522832 SRC_HUMAN (868-1151): 7e-99: 326: 31.23		P2RY2_HUMAN (1-376): 4.48e-63: 207: 20.96
+	Hs
		433268 YES_HUMAN (868-1151): 1.52e-97: 322: 30.53		CCR1_HUMAN (18-363): 9.03e-64: 209: 24.78
+	Hs
		669153 TYK2_HUMAN (867-1152): 1.57e-32: 139: 19.00		CXCR4_HUMAN (4-325): 2.98e-79: 249: 27.69
+	Hs
		854164 JAK3_HUMAN (855-1153): 6.11e-32: 137: 18.01		CXCR4_HUMAN (4-325): 2.98e-79: 249: 27.69
+	Hs
		796464 ZAP70_HUMAN (614-841): 8.24e-17: 87.4: 28.75		CXCR4_HUMAN (4-325): 2.98e-79: 249: 27.69
+	Hs
		895632 NTRK3_HUMAN (578-853): 5.4e-14: 79: 26.40		CXCR4_HUMAN (4-325): 2.98e-79: 249: 27.69