Protein: SDC4
Syndecan-4 (SYND4) (Amphiglycan) (Ryudocan core protein)

Gene: SDC4
Organism: Homo sapiens
Interactions: 111
UniProt ID: P31431

Gene Ontology (top 5):
GO:0001657 - ureteric bud development
GO:0001843 - neural tube closure
GO:0001968 - fibronectin binding
GO:0005080 - protein kinase C binding
GO:0005796 - Golgi lumen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

726640

SDC2
Syndecan-2

3

15

Small-scale

0.847

High

726638

SDC4
Syndecan-4

1

10

Small-scale

0.680

High

426941

FGF1
Fibroblast growth factor 1

3

8

High-throughput

0.667

High

478453

FGF2
Fibroblast growth factor 2

3

8

Small-scale

0.656

High

193509

PDPK1
3-phosphoinositide-dependent protein kinase 1

3

2

High-throughput

0.650

High

269906

SDC3
Syndecan-3

1

15

Small-scale

0.647

High

726639

GP183
G-protein coupled receptor 183

2

4

High-throughput

0.628

High

226713

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

3

1

High-throughput

0.616

High

507580

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

3

High-throughput

0.602

High

726679

CAMKV
CaM kinase-like vesicle-associated protein

2

2

High-throughput

0.601

High

599164

IL7RA
Interleukin-7 receptor subunit alpha

2

0

High-throughput

0.580

High

726651

PMP22
Peripheral myelin protein 22

2

0

High-throughput

0.580

High

395569

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

726689

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

2

1

High-throughput

0.553

High

726643

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

2

5

High-throughput

0.549

High

726647

ECHB
Trifunctional enzyme subunit beta, mitochondrial

2

3

High-throughput

0.549

High

726674

TM192
Transmembrane protein 192

2

1

High-throughput

0.549

High

726687

TM186
Transmembrane protein 186

2

1

High-throughput

0.549

High

726701

EVA1B
Protein eva-1 homolog B

2

1

High-throughput

0.549

High

501920

H2AZ
Histone H2A.Z

1

2

High-throughput

0.536

High

641128

FGFR2
Fibroblast growth factor receptor 2

1

4

High-throughput

0.536

High

650062

FGFR3
Fibroblast growth factor receptor 3

1

5

High-throughput

0.536

High

709257

AA2BR
Adenosine receptor A2b

1

2

High-throughput

0.536

High

726672

SULF2
Extracellular sulfatase Sulf-2

1

2

High-throughput

0.536

High

726680

VANG1
Vang-like protein 1

1

5

High-throughput

0.536

High

726692

CQ080
Mitochondrial nucleoid-associated protein 1

1

1

High-throughput

0.536

High

726707

VANG2
Vang-like protein 2

1

5

High-throughput

0.536

High

528387

TGFB3
Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.518

High

726652

TGBR3
Transforming growth factor beta receptor type 3

1

0

High-throughput

0.513

High

726665

CARL1
F-actin-uncapping protein LRRC16A

1

0

High-throughput

0.513

High

726684

KRT35
Keratin, type I cuticular Ha5

1

0

High-throughput

0.513

High

140152

SDCB1
Syntenin-1

1

4

Small-scale

0.501

High

421576

A4
Amyloid-beta precursor protein

1

2

Small-scale

0.501

High

603180

KPCA
Protein kinase C alpha type

1

4

Small-scale

0.501

High

726649

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

Small-scale

0.501

High

726657

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

2

Small-scale

0.501

High

726708

ALK
ALK tyrosine kinase receptor

1

5

High-throughput

0.500

High

167573

GIPC1
PDZ domain-containing protein GIPC1

1

0

Small-scale

0.493

High

472386

FGF4
Fibroblast growth factor 4

1

8

High-throughput

0.489

High

517617

ZBT48
Zinc finger and BTB domain-containing protein 48

1

1

High-throughput

0.489

High

726650

AMPD2
AMP deaminase 2

1

2

High-throughput

0.489

High

726653

ZNF92
Zinc finger protein 92

1

1

High-throughput

0.489

High

726655

GALT2
Polypeptide N-acetylgalactosaminyltransferase 2

1

1

High-throughput

0.489

High

726656

TF3C1
General transcription factor 3C polypeptide 1

1

2

High-throughput

0.489

High

726659

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

4

High-throughput

0.489

High

726683

TF3C2
General transcription factor 3C polypeptide 2

1

1

High-throughput

0.489

High

726697

PRD10
PR domain zinc finger protein 10

1

4

High-throughput

0.489

High

726703

DAXX
Death domain-associated protein 6

1

1

High-throughput

0.489

High

726704

PARP2
Poly [ADP-ribose] polymerase 2

1

2

High-throughput

0.489

High

726705

GMEB2
Glucocorticoid modulatory element-binding protein 2

1

5

High-throughput

0.489

High

726709

ZBTB1
Zinc finger and BTB domain-containing protein 1

1

4

High-throughput

0.489

High

726710

GMEB1
Glucocorticoid modulatory element-binding protein 1

1

5

High-throughput

0.489

High

726662

LTBP2
Latent-transforming growth factor beta-binding protein 2

1

0

Small-scale

0.480

High

362842

EGFR
Epidermal growth factor receptor

1

6

High-throughput

0.479

High

410652

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

6

High-throughput

0.479

High

726642

BASI
Basigin

1

2

High-throughput

0.479

High

726660

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

726671

TAXB1
Tax1-binding protein 1

1

4

High-throughput

0.479

High

550875

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

726677

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.458

High

726693

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

726696

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

Small-scale

0.458

High

351876

S1PR4
Sphingosine 1-phosphate receptor 4

1

2

High-throughput

0.445

High

563281

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

639105

SYT1
Synaptotagmin-1

1

3

High-throughput

0.445

High

702747

5HT2C
5-hydroxytryptamine receptor 2C

1

1

High-throughput

0.445

High

722861

SSR2
Somatostatin receptor type 2

1

2

High-throughput

0.445

High

726641

MERL
Merlin

1

5

High-throughput

0.445

High

726644

P2RY1
P2Y purinoceptor 1

1

4

High-throughput

0.445

High

726645

EFNB2
Ephrin-B2

1

2

High-throughput

0.445

High

726648

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.445

High

726667

CAVN1
Caveolae-associated protein 1

1

2

High-throughput

0.445

High

726676

LAT4
Large neutral amino acids transporter small subunit 4

1

1

High-throughput

0.445

High

726678

SYT2
Synaptotagmin-2

1

3

High-throughput

0.445

High

726681

SPP2B
Signal peptide peptidase-like 2B

1

1

High-throughput

0.445

High

726690

LIGO1
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

1

1

High-throughput

0.445

High

726700

EXOC1
Exocyst complex component 1

1

1

High-throughput

0.445

High

75756

B3KW44
tRNA N(3)-cytidine methyltransferase

1

3

High-throughput

0.437

High

371278

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

562873

CCL5
C-C motif chemokine 5

1

1

Small-scale

0.437

High

726658

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

4

High-throughput

0.437

High

726666

IFIX
Pyrin and HIN domain-containing protein 1

1

3

High-throughput

0.437

High

726688

OPTN
Optineurin

1

2

High-throughput

0.437

High

726694

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.437

High

726675

S35F6
Solute carrier family 35 member F6

1

0

High-throughput

0.426

High

726685

EDA
Ectodysplasin-A

1

0

High-throughput

0.426

High

215981

FIBP
Acidic fibroblast growth factor intracellular-binding protein

1

2

High-throughput

0.407

High

269995

XYLK
Glycosaminoglycan xylosylkinase

1

1

Small-scale

0.407

High

337689

SGPL1
Sphingosine-1-phosphate lyase 1

1

2

High-throughput

0.407

High

726646

VMAT1
Chromaffin granule amine transporter

1

1

High-throughput

0.407

High

726654

ECHP
Peroxisomal bifunctional enzyme

1

5

High-throughput

0.407

High

726664

NCBP3
Nuclear cap-binding protein subunit 3

1

1

High-throughput

0.407

High

726669

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

1

6

High-throughput

0.407

High

726670

LRRT4
Leucine-rich repeat transmembrane neuronal protein 4

1

6

High-throughput

0.407

High

726673

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

726682

EOLA1
Protein EOLA1

1

2

High-throughput

0.407

High

726691

TEAN2
Transcription elongation factor A N-terminal and central domain-containing protein 2

1

1

High-throughput

0.407

High

726695

METL8
tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial

1

3

High-throughput

0.407

High

726702

KANL3
KAT8 regulatory NSL complex subunit 3

1

1

High-throughput

0.407

High

636201

MAL
Myelin and lymphocyte protein

2

0

High-throughput

0.316

High

726706

PLAT4
Phospholipase A and acyltransferase 4

1

0

Small-scale

0.288

High

726686

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.282

High

726663

DREB
Drebrin

1

0

High-throughput

0.279

Low

726699

ABCBA
ATP-binding cassette sub-family B member 10, mitochondrial

1

0

High-throughput

0.279

Low

159318

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

0

Small-scale

0.249

Low

726661

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.249

Low

726668

GP179
Probable G-protein coupled receptor 179

1

0

Small-scale

0.249

Low

726698

ANLN
Anillin

1

0

High-throughput

0.249

Low

547973

PSPC
Surfactant protein C

1

0

High-throughput

0.232

Low

584068

FOSL2
Fos-related antigen 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025