Interactor 1: JAK1 (P23458)
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
Gene: JAK1
Interactor 2: STAT1 (P42224)
Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84)
Gene: STAT1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.95 | 1.00 | 0.976 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 32123171, 32814877, 34950606, 15284024, 32953130, 34228987, 35317858, 14978237, 15978943, 34521819 |
| Identification Methods | enzymatic study, affinity chromatography technology, anti tag coimmunoprecipitation |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | FERM_F1~SH2, PK_Tyr_Ser-Thr~SH2 |
| Common GO terms | GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007259 - cell surface receptor signaling pathway via JAK-STAT GO:0031730 - CCR5 chemokine receptor binding and 3 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
