HitPredict

Interactor 1: COF1 (P23528)
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)
Gene: CFL1

Interactor 2: ACTS (P68133)
Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form]
Gene: ACTA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	11950878, 21723825
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Actin~Cofilin_ADF
Common GO terms	GO:0005615 - extracellular space GO:0005829 - cytosol GO:0015629 - actin cytoskeleton GO:0030027 - lamellipodium GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 166 Hs			1 377
+	Mm
		578583 COF1_MOUSE (1-166): 1.35e-72: 217: 98.80		ACTB_MOUSE (5-377): 0: 604: 93.83
+	Rn
		799735 COF1_RAT (1-166): 3.11e-72: 216: 99.40		ACTB_RAT (5-377): 0: 604: 93.83
+	Hs
		618038 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		ACTB_HUMAN (5-377): 0: 604: 93.83
+	Hs
		618049 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		ACTG_HUMAN (4-377): 0: 604: 93.85
+	Hs
		618052 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		ACTC_HUMAN (1-377): 0: 604: 98.94
+	Hs
		618096 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		Q1KLZ0_HUMAN (5-377): 0: 604: 93.83
+	Hs
		1092828 Q549N0_HUMAN (1-166): 1.68e-71: 214: 80.72		Q1KLZ0_HUMAN (5-377): 0: 604: 93.83
+	Hs
		891817 Q549N0_HUMAN (1-166): 1.68e-71: 214: 80.72		ACTB_HUMAN (5-377): 0: 604: 93.83
+	Hs
		892124 COF2_HUMAN (1-166): 1.68e-71: 214: 80.72		ACTB_HUMAN (5-377): 0: 604: 93.83
+	Hs
		929891 Q549N0_HUMAN (1-166): 1.68e-71: 214: 80.72		ACTG_HUMAN (4-377): 0: 604: 93.85
+	Hs
		930059 COF2_HUMAN (1-166): 1.68e-71: 214: 80.72		ACTG_HUMAN (4-377): 0: 604: 93.85
+	Hs
		932464 COF2_HUMAN (1-166): 1.68e-71: 214: 80.72		ACTC_HUMAN (1-377): 0: 604: 98.94
+	Hs
		618046 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		ACTA_HUMAN (1-377): 0: 602: 97.88
+	Hs
		618050 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		ACTH_HUMAN (4-377): 0: 597: 98.40
+	Hs
		891649 DEST_HUMAN (1-166): 3.71e-69: 208: 71.08		ACTB_HUMAN (5-377): 0: 604: 93.83
+	Hs
		894652 DEST_HUMAN (1-166): 3.71e-69: 208: 71.08		ACTG_HUMAN (4-377): 0: 604: 93.85
+	Hs
		894665 DEST_HUMAN (1-166): 3.71e-69: 208: 71.08		Q1KLZ0_HUMAN (5-377): 0: 604: 93.83
+	Hs
		894651 DEST_HUMAN (1-166): 3.71e-69: 208: 71.08		ACTA_HUMAN (1-377): 0: 602: 97.88
+	At
		477715 ADF4_ARATH (2-146): 7.32e-49: 156: 34.93		ACT1_ARATH (1-377): 0: 597: 87.80
+	At
		477714 ADF6_ARATH (3-152): 1.7e-47: 152: 30.46		ACT1_ARATH (1-377): 0: 597: 87.80