HitPredict

Interactor 1: IF4B (P23588)
Eukaryotic translation initiation factor 4B (eIF-4B)
Gene: EIF4B

Interactor 2: EIF3B (P55884)
Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116)
Gene: EIF3B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.855

Property	Details
Experiments	29228324, 16286006, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0003743 - translation initiation factor activity GO:0005829 - cytosol GO:0006446 - regulation of translational initiation
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 611 Hs			1 814
+	Hs
		516430 PABP1_HUMAN (49-537): 3.4e-25: 112: 10.22		EIF3B_HUMAN (1-814): 0: 830: 100.00
+	Hs
		879239 PABP4_HUMAN (49-389): 1.92e-21: 100: 9.72		EIF3B_HUMAN (1-814): 0: 830: 100.00
+	Sc
		376575 PABP_YEAST (7-185): 1.17e-23: 107: 16.58		EIF3B_YEAST (139-790): 1.9e-118: 377: 29.36
+	Sc
		376867 PABP_YEAST (7-185): 1.17e-23: 107: 16.58		EIF2A_YEAST (343-705): 1.57e-86: 289: 19.95
+	Sc
		648402 NSR1_YEAST (84-187): 1.96e-10: 65.3: 20.00		EIF2A_YEAST (343-705): 1.57e-86: 289: 19.95
+	Hs
		903215 CIRBP_HUMAN (98-257): 1.65e-29: 116: 24.85		WDR5_HUMAN (554-729): 7.19e-35: 137: 12.71
+	Hs
		516438 PABP1_HUMAN (49-537): 3.4e-25: 112: 10.22		WDR5_HUMAN (554-729): 7.19e-35: 137: 12.71
+	Hs
		903196 PABP4_HUMAN (49-389): 1.92e-21: 100: 9.72		WDR5_HUMAN (554-729): 7.19e-35: 137: 12.71