Protein: FAS2
Fatty acid synthase subunit alpha (EC 2.3.1.86) [Includes: Acyl carrier; 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) (Beta-ketoacyl reductase); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41) (Beta-ketoacyl synthase)]

Gene: FAS2
Organism: Saccharomyces cerevisiae S288C
Interactions: 125
UniProt ID: P19097

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004312 - fatty acid synthase activity
GO:0004315 - 3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0004316 - 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
GO:0004321 - fatty-acyl-CoA synthase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

450518

FAS1
Fatty acid synthase subunit beta

8

7

Small-scale

0.973

High

618543

FAS2
Fatty acid synthase subunit alpha

1

14

High-throughput

0.618

High

618601

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

3

0

High-throughput

0.613

High

618550

SIS1
Protein SIS1

2

2

High-throughput

0.601

High

618579

ATG8
Autophagy-related protein 8

2

5

Small-scale

0.584

High

392195

HSP82
ATP-dependent molecular chaperone HSP82

2

4

High-throughput

0.571

High

543759

SSB1
Ribosome-associated molecular chaperone SSB1

2

4

High-throughput

0.571

High

618554

MAS5
Mitochondrial protein import protein MAS5

2

2

High-throughput

0.571

High

523002

HSP71
Heat shock protein SSA1

2

3

High-throughput

0.552

High

618561

HS104
Heat shock protein 104

2

0

High-throughput

0.547

High

618565

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.536

High

618593

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.536

High

618611

BRE5
UBP3-associated protein BRE5

1

1

High-throughput

0.536

High

618616

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

3

High-throughput

0.536

High

618563

HOG1
Mitogen-activated protein kinase HOG1

2

3

High-throughput

0.533

High

618586

YCFI
Metal resistance protein YCF1

1

2

High-throughput

0.494

High

454858

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

578808

HSC82
ATP-dependent molecular chaperone HSC82

1

4

High-throughput

0.479

High

618546

HSP74
Heat shock protein SSA4

1

3

High-throughput

0.479

High

618556

CDC48
Cell division control protein 48

1

2

High-throughput

0.479

High

618566

HFA1
Acetyl-CoA carboxylase, mitochondrial

1

3

High-throughput

0.479

High

618577

GBLP
Small ribosomal subunit protein RACK1

1

1

High-throughput

0.479

High

618615

NUM1
Nuclear migration protein NUM1

1

1

High-throughput

0.479

High

149569

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

383504

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

401874

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.458

High

409924

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

430779

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

0

Small-scale

0.458

High

433433

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

434803

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

435758

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

441691

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

448638

SNF1
Carbon catabolite-derepressing protein kinase

1

0

Small-scale

0.458

High

454697

KAPR
cAMP-dependent protein kinase regulatory subunit

1

0

Small-scale

0.458

High

502836

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.458

High

504026

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.458

High

512244

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.458

High

512803

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.458

High

514442

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

618545

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.458

High

618553

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

618557

RL16A
Large ribosomal subunit protein uL13A

1

0

High-throughput

0.458

High

618558

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

618567

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.458

High

618568

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

618570

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

618575

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

618580

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.458

High

618582

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

618585

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

618588

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

618597

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.458

High

618599

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

618604

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.458

High

618607

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

618609

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

618614

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.458

High

618618

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

618622

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.458

High

618626

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

618628

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

618630

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

618638

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

525875

HSP72
Heat shock protein SSA2

1

3

High-throughput

0.445

High

618562

APE2
Aminopeptidase 2, mitochondrial

1

2

High-throughput

0.445

High

618589

HSP7E
Heat shock protein SSC3, mitochondrial

1

4

High-throughput

0.445

High

618612

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.445

High

618632

SMT3
Ubiquitin-like protein SMT3

1

1

High-throughput

0.439

High

438613

SC160
Protein SCP160

1

3

High-throughput

0.437

High

464546

PBS2
MAP kinase kinase PBS2

1

2

High-throughput

0.437

High

618559

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

618560

BMH1
Protein BMH1

1

1

Small-scale

0.437

High

618569

PRS6A
26S proteasome regulatory subunit 6A

1

3

High-throughput

0.437

High

618571

BMH2
Protein BMH2

1

1

Small-scale

0.437

High

618583

ECM29
Proteasome component ECM29

1

1

High-throughput

0.437

High

618584

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.437

High

618587

DHH1
ATP-dependent RNA helicase DHH1

1

1

High-throughput

0.437

High

618594

TM108
Protein TMA108

1

2

High-throughput

0.437

High

618620

TOM1
E3 ubiquitin-protein ligase TOM1

1

3

High-throughput

0.437

High

618621

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.437

High

618633

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.437

High

618634

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.437

High

618549

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

High-throughput

0.426

High

618551

YCP4
Flavoprotein-like protein YCP4

1

0

High-throughput

0.426

High

618552

LSB5
LAS seventeen-binding protein 5

1

0

High-throughput

0.426

High

438249

NOT3
General negative regulator of transcription subunit 3

2

0

High-throughput

0.307

High

618544

UBR1
E3 ubiquitin-protein ligase UBR1

2

0

Small-scale

0.305

High

618595

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.305

High

618623

UFO1
Ubiquitin ligase complex F-box protein UFO1

1

0

Small-scale

0.292

High

618619

YMY9
Glucose-6-phosphate 1-epimerase

1

0

High-throughput

0.279

Low

618635

NOP58
Nucleolar protein 58

1

0

High-throughput

0.279

Low

618613

SLM2
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM2

1

0

High-throughput

0.269

Low

618547

KCC2
Calcium/calmodulin-dependent protein kinase II

1

0

High-throughput

0.249

Low

618548

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.249

Low

618555

SGF29
SAGA complex subunit SGF29

1

0

Small-scale

0.249

Low

618572

SPT10
Protein SPT10

1

0

High-throughput

0.249

Low

618573

SPT21
Protein SPT21

1

0

High-throughput

0.249

Low

618574

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.249

Low

618576

CENPA
Histone H3-like centromeric protein CSE4

1

0

High-throughput

0.249

Low

618581

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.249

Low

618592

FTR1
Plasma membrane iron permease

1

0

High-throughput

0.249

Low

618596

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.249

Low

618598

MID1
Stretch-activated cation channel MID1

1

0

Small-scale

0.249

Low

618600

SET4
SET domain-containing protein 4

1

0

Small-scale

0.249

Low

618605

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

618608

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

618610

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

618617

MDM1
Structural protein MDM1

1

0

Small-scale

0.249

Low

618624

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.249

Low

618625

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

618629

NCBP2
Nuclear cap-binding protein subunit 2

1

0

High-throughput

0.249

Low

618631

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.249

Low

618639

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low

597706

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.232

Low

618564

SMI1
Cell wall assembly regulator SMI1

1

0

High-throughput

0.232

Low

618578

SEA4
SEH-associated protein 4

1

0

High-throughput

0.232

Low

618590

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.232

Low

618591

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

0

High-throughput

0.232

Low

618602

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

618603

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.232

Low

618606

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.232

Low

618627

AB140
tRNA(Thr)

1

0

High-throughput

0.232

Low

618636

SET6
Potential protein lysine methyltransferase SET6

1

0

High-throughput

0.232

Low

618637

H2AZ
Histone H2A.Z

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025