HitPredict

Interactor 1: AT2B4 (P23634)
Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4)
Gene: ATP2B4

Interactor 2: P2RY8 (Q86VZ1)
P2Y purinoceptor 8 (P2Y8)
Gene: P2RY8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1241 Hs			1 359
+	Hs
		619229 AT2B4_HUMAN (1-1241): 0: 1300: 100.00		GPR17_HUMAN (15-331): 1.86e-84: 262: 28.53
+	Hs
		619207 AT2B4_HUMAN (1-1241): 0: 1300: 100.00		P2RY2_HUMAN (7-345): 1.15e-81: 255: 29.56
+	Hs
		619214 AT2B4_HUMAN (1-1241): 0: 1300: 100.00		CCR6_HUMAN (12-344): 5.37e-82: 255: 21.22
+	Hs
		428921 AT2B4_HUMAN (1-1241): 0: 1300: 100.00		ADRB2_HUMAN (4-332): 2.82e-71: 229: 15.88
+	Hs
		208448 AT2B4_HUMAN (1-1241): 0: 1300: 100.00		OX2R_HUMAN (15-338): 7.54e-69: 224: 16.67
+	Hs
		619204 AT2B4_HUMAN (1-1241): 0: 1300: 100.00		APJ_HUMAN (14-346): 1.38e-68: 221: 22.97
+	Hs
		619206 AT2B4_HUMAN (1-1241): 0: 1300: 100.00		OPRX_HUMAN (11-350): 2.02e-67: 218: 23.55
+	Hs
		619243 AT2B4_HUMAN (1-1241): 0: 1300: 100.00		OR2G6_HUMAN (2-319): 1.38e-67: 217: 15.84
+	Hs
		619202 AT2B4_HUMAN (1-1241): 0: 1300: 100.00		AGTR1_HUMAN (18-345): 2.09e-66: 215: 23.08
+	Hs
		619198 AT2B4_HUMAN (1-1241): 0: 1300: 100.00		NK3R_HUMAN (4-337): 4.85e-64: 212: 18.61
+	Hs
		895636 AT2B3_HUMAN (1-1241): 0: 1164: 71.63		CXCR4_HUMAN (23-308): 3.55e-84: 261: 25.26
+	Hs
		782425 AT2B3_HUMAN (1-1241): 0: 1164: 71.63		P2RY2_HUMAN (7-345): 1.15e-81: 255: 29.56
+	Hs
		126568 AT2B4_HUMAN (1-1241): 0: 1300: 100.00		P2Y10_HUMAN (30-307): 9.64e-30: 118: 34.46
+	Hs
		1086542 AT2B3_HUMAN (1-1241): 0: 1164: 71.63		P2RY8_HUMAN (1-359): 1.75e-78: 246: 100.00
+	Hs
		619279 AT2B4_HUMAN (1-1241): 0: 1300: 100.00		CML1_HUMAN (24-330): 1.18e-25: 107: 27.41
+	Hs
		208456 AT2B3_HUMAN (1-1241): 0: 1164: 71.63		OX2R_HUMAN (15-338): 7.54e-69: 224: 16.67
+	Hs
		781059 AT2B3_HUMAN (1-1241): 0: 1164: 71.63		OPRX_HUMAN (11-350): 2.02e-67: 218: 23.55
+	Hs
		674851 AT2B3_HUMAN (1-1241): 0: 1164: 71.63		AGTR1_HUMAN (18-345): 2.09e-66: 215: 23.08
+	Hs
		208453 AT2B2_HUMAN (3-1241): 0: 1154: 68.59		OX2R_HUMAN (15-338): 7.54e-69: 224: 16.67
+	Hs
		666307 AT2B2_HUMAN (3-1241): 0: 1154: 68.59		NK3R_HUMAN (4-337): 4.85e-64: 212: 18.61