HitPredict - High confidence protein-protein interactions

Interactor 1: GATA2 (P23769)
Endothelial transcription factor GATA-2 (GATA-binding protein 2)
Gene: GATA2

Interactor 2: SMAD4 (Q13485)
Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)
Gene: SMAD4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	20211142, 21988832
Identification Methods	two hybrid, affinity chromatography technology, pull down, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0001223 - transcription coactivator binding GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific and 11 others more... GO:0003682 - chromatin binding GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex GO:0005737 - cytoplasm GO:0006366 - transcription by RNA polymerase II GO:0010628 - positive regulation of gene expression GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:1902895 - positive regulation of miRNA transcription
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	480
Hs

1	552

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Last updated: 15 Jul 2024