HitPredict

Interactor 1: PRP22 (P24384)
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22 (EC 3.6.4.13)
Gene: PRP22

Interactor 2: CLF1 (Q12309)
Pre-mRNA-splicing factor CLF1 (Crooked neck-like factor 1) (PRP19-associated complex protein 77) (Synthetic lethal with CDC40 protein 3)
Gene: CLF1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.708

Property	Details
Experiments	11102353, 12509417, 12554883, 29146870, 20089683
Identification Methods	two hybrid, affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0071007 - U2-type catalytic step 2 spliceosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1145 Sc			1 687
+	Hs
		1055473 DHX8_HUMAN (1-1137): 0: 949: 40.81		CRNL1_HUMAN (5-685): 4.45e-115: 367: 36.61
+	Sc
		622340 PRP22_YEAST (1-1145): 0: 1020: 100.00		SYF1_YEAST (54-674): 1.42e-57: 211: 11.97
+	Sc
		589465 PRP2_YEAST (252-1113): 0: 837: 34.18		CLF1_YEAST (1-687): 7.93e-126: 390: 100.00
+	Sp
		194928 DHX15_SCHPO (410-1129): 0: 716: 44.82		CLF1_SCHPO (5-686): 5.61e-121: 377: 39.21
+	Sc
		859463 PRP43_YEAST (416-1106): 0: 700: 45.80		CLF1_YEAST (1-687): 7.93e-126: 390: 100.00
+	Hs
		1055483 DHX8_HUMAN (1-1137): 0: 949: 40.81		SYF1_HUMAN (2-495): 4.59e-26: 116: 14.67
+	Sc
		554256 PRP16_YEAST (217-1109): 0: 670: 35.31		CLF1_YEAST (1-687): 7.93e-126: 390: 100.00
+	Sc
		589452 PRP2_YEAST (252-1113): 0: 837: 34.18		SYF1_YEAST (54-674): 1.42e-57: 211: 11.97
+	Hs
		1055399 DHX8_HUMAN (1-1137): 0: 949: 40.81		CTR9_HUMAN (9-434): 5.17e-19: 94.2: 8.39
+	Hs
		300141 DHX8_HUMAN (1-1137): 0: 949: 40.81		PRP6_HUMAN (449-672): 5e-10: 64.9: 11.89
+	Hs
		1160938 DHX40_HUMAN (433-1130): 0: 826: 37.62		CTR9_HUMAN (9-434): 5.17e-19: 94.2: 8.39
+	Hs
		1057967 DHX40_HUMAN (433-1130): 0: 826: 37.62		RRP5_HUMAN (376-677): 7.52e-17: 87.3: 13.58
+	Sc
		586358 PRP2_YEAST (252-1113): 0: 837: 34.18		PRP6_YEAST (28-198): 6.71e-10: 64.6: 13.30
+	Hs
		224847 DHX16_HUMAN (242-1114): 0: 780: 41.22		SYF1_HUMAN (2-495): 4.59e-26: 116: 14.67
+	Sc
		554246 PRP16_YEAST (217-1109): 0: 670: 35.31		SYF1_YEAST (54-674): 1.42e-57: 211: 11.97
+	Hs
		174828 DHX9_HUMAN (109-1144): 0: 683: 20.04		OGT1_HUMAN (3-340): 4.64e-40: 160: 14.12
+	Sc
		859429 PRP43_YEAST (416-1106): 0: 700: 45.80		RRP5_YEAST (335-642): 1.55e-24: 111: 14.56
+	Hs
		994172 DHX9_HUMAN (109-1144): 0: 683: 20.04		SART3_HUMAN (21-387): 2.31e-11: 69.2: 15.08