Interactor 1: RO52 (P19474)
E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)
Gene: TRIM21

Interactor 2: SPRY3 (Q8NCJ5)
SPRY domain-containing protein 3
Gene: SPRYD3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.38 0.80 0.553

The method score is based on:

Property Details
Experiments 37249651
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PRY~SPRY, SPRY~SPRY
Common GO terms -
Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 475
Hs

1 442
+ Hs
+ Hs
+ Hs

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Last updated: 11Aug2025