HitPredict

Interactor 1: CCNE1 (P24864)
G1/S-specific cyclin-E1
Gene: CCNE1

Interactor 2: RBL2 (Q08999)
Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2)
Gene: RBL2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	9891079, 8253383
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 410 Hs			1 1139
+	Hs
		590169 CCNA2_HUMAN (2-369): 1.62e-99: 304: 20.58		RBL2_HUMAN (1-1139): 0: 1591: 100.00
+	Hs
		331639 CCNE2_HUMAN (4-402): 7.36e-97: 297: 47.38		RBL2_HUMAN (1-1139): 0: 1591: 100.00
+	Hs
		943777 CCNA1_HUMAN (15-367): 4.41e-96: 297: 20.98		RBL2_HUMAN (1-1139): 0: 1591: 100.00
+	Hs
		538529 CCNB1_HUMAN (1-365): 5.55e-95: 293: 18.82		RBL2_HUMAN (1-1139): 0: 1591: 100.00
+	Hs
		624544 CCNE1_HUMAN (1-410): 2.36e-135: 395: 100.00		RBL1_HUMAN (51-1139): 0: 1396: 50.59
+	Hs
		590128 CCNA2_HUMAN (2-369): 1.62e-99: 304: 20.58		RBL1_HUMAN (51-1139): 0: 1396: 50.59
+	Hs
		660112 CCNA1_HUMAN (15-367): 4.41e-96: 297: 20.98		RBL1_HUMAN (51-1139): 0: 1396: 50.59
+	Hs
		414171 CCNE1_HUMAN (1-410): 2.36e-135: 395: 100.00		RB_HUMAN (775-999): 1.19e-64: 239: 29.39
+	Hs
		414164 CCNA2_HUMAN (2-369): 1.62e-99: 304: 20.58		RB_HUMAN (775-999): 1.19e-64: 239: 29.39
+	Hs
		414240 CCNA1_HUMAN (15-367): 4.41e-96: 297: 20.98		RB_HUMAN (775-999): 1.19e-64: 239: 29.39
+	Hs
		414150 CCNB1_HUMAN (1-365): 5.55e-95: 293: 18.82		RB_HUMAN (775-999): 1.19e-64: 239: 29.39
+	Dm
		872346 CCNE_DROME (47-402): 3.64e-91: 291: 38.79		RBF_DROME (828-1097): 1.21e-42: 170: 26.81