HitPredict

Interactor 1: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Interactor 2: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	20679368, 37827155, 8397206
Identification Methods	affinity chromatography technology, proximity labelling technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006260 - DNA replication GO:0006281 - DNA repair and 1 others more... GO:0051321 - meiotic cell cycle
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 298 Hs			1 616
+	Hs
		414753 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		650972 CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		650694 CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		650973 CDK16_HUMAN (1-286): 4.1e-107: 322: 55.40		RFA1_HUMAN (1-616): 0: 781: 100.00