Protein: SF3A3
Splicing factor 3A subunit 3 (SF3a60) (Spliceosome-associated protein 61) (SAP 61)

Gene: SF3A3
Organism: Homo sapiens
Interactions: 219
UniProt ID: Q12874

Gene Ontology (top 5):
GO:0000375 - RNA splicing, via transesterification reactions
GO:0000389 - mRNA 3'-splice site recognition
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1088672

SF3A1
Splicing factor 3A subunit 1

15

4

Small-scale

0.986

High

1088669

SF3B3
Splicing factor 3B subunit 3

5

1

High-throughput

0.919

High

1088725

SPF45
Splicing factor 45

4

2

High-throughput

0.903

High

1088652

SF3B2
Splicing factor 3B subunit 2

4

1

High-throughput

0.886

High

973894

RUXF
Small nuclear ribonucleoprotein F

3

5

High-throughput

0.871

High

471821

RU2B
U2 small nuclear ribonucleoprotein B''

3

4

High-throughput

0.861

High

775045

FUS
RNA-binding protein FUS

3

2

High-throughput

0.847

High

1088674

U2AFM
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

3

0

High-throughput

0.816

High

574238

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

2

High-throughput

0.811

High

973696

RUXE
Small nuclear ribonucleoprotein E

2

1

High-throughput

0.811

High

991170

RSMN
Small nuclear ribonucleoprotein-associated protein N

2

2

High-throughput

0.811

High

974120

RUXG
Small nuclear ribonucleoprotein G

2

7

High-throughput

0.789

High

1088659

RBM39
RNA-binding protein 39

2

2

High-throughput

0.789

High

1088758

SF3B6
Splicing factor 3B subunit 6

2

3

High-throughput

0.789

High

1088759

RBM7
RNA-binding protein 7

2

2

High-throughput

0.789

High

485617

RU2A
U2 small nuclear ribonucleoprotein A'

8

1

Small-scale

0.749

High

478017

SNRPA
U1 small nuclear ribonucleoprotein A

1

4

High-throughput

0.691

High

974371

SMD1
Small nuclear ribonucleoprotein Sm D1

1

5

High-throughput

0.691

High

974534

SMD2
Small nuclear ribonucleoprotein Sm D2

1

2

High-throughput

0.691

High

1016410

SRSF3
Serine/arginine-rich splicing factor 3

1

1

High-throughput

0.691

High

1088668

RNPS1
RNA-binding protein with serine-rich domain 1

1

4

High-throughput

0.691

High

1088671

SF3A2
Splicing factor 3A subunit 2

4

2

Small-scale

0.686

High

537062

HSP7C
Heat shock cognate 71 kDa protein

3

1

High-throughput

0.667

High

1088755

PUF60
Poly(U)-binding-splicing factor PUF60

1

1

High-throughput

0.665

High

913925

RBM5
RNA-binding protein 5

1

0

High-throughput

0.656

High

371891

MYC
Myc proto-oncogene protein

3

3

High-throughput

0.640

High

283465

TAD2A
Transcriptional adapter 2-alpha

2

1

High-throughput

0.633

High

1088697

TRI69
E3 ubiquitin-protein ligase TRIM69

2

1

High-throughput

0.633

High

1088691

PHF5A
PHD finger-like domain-containing protein 5A

2

1

High-throughput

0.628

High

175659

SR140
U2 snRNP-associated SURP motif-containing protein

1

1

High-throughput

0.618

High

1088670

SF3B4
Splicing factor 3B subunit 4

1

1

High-throughput

0.618

High

1088700

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

5

High-throughput

0.618

High

1088716

RBP56
TATA-binding protein-associated factor 2N

1

1

High-throughput

0.618

High

285894

SF3B1
Splicing factor 3B subunit 1

2

1

High-throughput

0.611

High

1088739

SF3B5
Splicing factor 3B subunit 5

2

1

High-throughput

0.611

High

1088723

CCD97
Coiled-coil domain-containing protein 97

2

0

High-throughput

0.602

High

1088751

ZN212
Zinc finger protein 212

2

0

High-throughput

0.601

High

162555

ANM5
Protein arginine N-methyltransferase 5

2

1

Small-scale

0.600

High

298507

SPF30
Survival of motor neuron-related-splicing factor 30

2

0

High-throughput

0.595

High

163754

TCRG1
Transcription elongation regulator 1

2

3

Small-scale

0.595

High

1088711

SREK1
Splicing regulatory glutamine/lysine-rich protein 1

1

0

Small-scale

0.586

High

1088760

SPIN1
Spindlin-1

2

0

High-throughput

0.585

High

1088715

KAT6A
Histone acetyltransferase KAT6A

2

1

Small-scale

0.584

High

71574

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

7

High-throughput

0.575

High

911566

NCBP2
Nuclear cap-binding protein subunit 2

1

4

High-throughput

0.575

High

241529

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

1067239

EP300
Histone acetyltransferase p300

2

0

High-throughput

0.559

High

1088663

EMC2
ER membrane protein complex subunit 2

2

3

High-throughput

0.558

High

415529

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.558

High

463485

LYN
Tyrosine-protein kinase Lyn

2

0

High-throughput

0.547

High

1088675

CC85B
Coiled-coil domain-containing protein 85B

1

1

High-throughput

0.541

High

529712

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.536

High

611844

RL35A
Large ribosomal subunit protein eL33

1

1

High-throughput

0.536

High

930864

HSP72
Heat shock-related 70 kDa protein 2

1

1

High-throughput

0.536

High

1088654

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.536

High

1088681

KDM4D
Lysine-specific demethylase 4D

1

1

High-throughput

0.536

High

1088695

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

1088717

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.536

High

1088732

CDC5L
Cell division cycle 5-like protein

1

3

High-throughput

0.536

High

1088735

FOXB1
Forkhead box protein B1

1

2

High-throughput

0.536

High

1088742

FOXQ1
Forkhead box protein Q1

1

2

High-throughput

0.536

High

1088744

KDM4C
Lysine-specific demethylase 4C

1

1

High-throughput

0.536

High

286453

WBP4
WW domain-binding protein 4

1

2

High-throughput

0.527

High

483446

ANXA4
Annexin A4

1

1

High-throughput

0.515

High

843520

HD
Huntingtin

1

1

High-throughput

0.515

High

298371

DNJC8
DnaJ homolog subfamily C member 8

1

0

High-throughput

0.513

High

336656

BAG4
BAG family molecular chaperone regulator 4

1

0

High-throughput

0.513

High

480113

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

854022

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.513

High

1088651

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

1088698

DDX42
ATP-dependent RNA helicase DDX42

1

0

High-throughput

0.513

High

1088704

TRM2A
tRNA

1

0

High-throughput

0.513

High

1088726

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

0

High-throughput

0.513

High

1088746

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.513

High

185644

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

280597

PR40A
Pre-mRNA-processing factor 40 homolog A

1

4

High-throughput

0.501

High

1088699

ZDH17
Palmitoyltransferase ZDHHC17

1

1

High-throughput

0.494

High

927263

ATX1
Ataxin-1

1

0

High-throughput

0.493

High

1088685

TTC33
Tetratricopeptide repeat protein 33

1

3

High-throughput

0.489

High

1088720

ARRD3
Arrestin domain-containing protein 3

1

2

High-throughput

0.489

High

913645

VAV2
Guanine nucleotide exchange factor VAV2

1

0

High-throughput

0.486

High

127069

APBB1
Amyloid beta precursor protein binding family B member 1

1

0

High-throughput

0.480

High

138088

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

1

High-throughput

0.479

High

157301

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

259868

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

285244

EED
Polycomb protein EED

1

2

High-throughput

0.479

High

330917

KI20A
Kinesin-like protein KIF20A

1

1

High-throughput

0.479

High

345729

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

370649

FOS
Protein c-Fos

1

1

High-throughput

0.479

High

406117

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.479

High

588565

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

623309

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.479

High

695320

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

768061

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

799048

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

897774

CDK9
Cyclin-dependent kinase 9

1

1

High-throughput

0.479

High

970413

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

998259

H31
Histone H3.1

1

2

High-throughput

0.479

High

1007678

RAE1L
mRNA export factor RAE1

1

1

High-throughput

0.479

High

1008702

RED1
Double-stranded RNA-specific editase 1

1

1

High-throughput

0.479

High

1026344

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

1088647

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

High-throughput

0.479

High

1088648

FOXC1
Forkhead box protein C1

1

1

High-throughput

0.479

High

1088650

RFA4
Replication protein A 30 kDa subunit

1

3

High-throughput

0.479

High

1088655

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1088665

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1088677

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

1088683

IFIX
Pyrin and HIN domain-containing protein 1

1

1

High-throughput

0.479

High

1088684

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.479

High

1088687

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1088690

MEPCE
7SK snRNA methylphosphate capping enzyme

1

1

High-throughput

0.479

High

1088722

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

1

High-throughput

0.479

High

1088733

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.479

High

1088736

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

1088740

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

1088748

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1088753

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

710204

EPHA2
Ephrin type-A receptor 2

1

1

High-throughput

0.470

High

65742

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

0

High-throughput

0.458

High

129026

MEN1
Menin

1

0

High-throughput

0.458

High

130739

TAF4
Transcription initiation factor TFIID subunit 4

1

0

High-throughput

0.458

High

134708

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.458

High

222985

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

315522

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

319720

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

324825

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

335826

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

0

High-throughput

0.458

High

467471

4F2
Amino acid transporter heavy chain SLC3A2

1

0

High-throughput

0.458

High

587462

TFE2
Transcription factor E2-alpha

1

0

High-throughput

0.458

High

606696

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

659771

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.458

High

681354

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.458

High

755895

MCM5
DNA replication licensing factor MCM5

1

0

High-throughput

0.458

High

760903

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.458

High

851539

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.458

High

879021

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

904653

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

926965

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

932856

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

0

High-throughput

0.458

High

957719

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

High-throughput

0.458

High

979571

H4
Histone H4

1

0

High-throughput

0.458

High

1088649

TP4A2
Protein tyrosine phosphatase type IVA 2

1

0

High-throughput

0.458

High

1088653

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1088656

FHL1
Four and a half LIM domains protein 1

1

0

High-throughput

0.458

High

1088660

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

High-throughput

0.458

High

1088662

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1088664

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

1088666

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1088680

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1088689

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.458

High

1088692

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

1088693

SLN11
Schlafen family member 11

1

0

Small-scale

0.458

High

1088694

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

1088702

ASXL1
Polycomb group protein ASXL1

1

0

High-throughput

0.458

High

1088703

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1088709

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.458

High

1088710

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1088713

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1088714

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1088718

FGF11
Fibroblast growth factor 11

1

0

High-throughput

0.458

High

1088719

FBXW7
F-box/WD repeat-containing protein 7

1

0

Small-scale

0.458

High

1088721

KCD12
BTB/POZ domain-containing protein KCTD12

1

0

Small-scale

0.458

High

1088728

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

1088729

CIC
Protein capicua homolog

1

0

High-throughput

0.458

High

1088731

CRBN
Protein cereblon

1

0

Small-scale

0.458

High

1088734

MYD88
Myeloid differentiation primary response protein MyD88

1

0

Small-scale

0.458

High

1088738

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1088741

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1088747

ANLN
Anillin

1

0

High-throughput

0.458

High

1088749

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

1088752

TRM7
tRNA

1

0

High-throughput

0.458

High

1088754

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.458

High

1088757

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.458

High

207513

DHX15
ATP-dependent RNA helicase DHX15

1

1

High-throughput

0.445

High

429799

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

1088673

SF01
Splicing factor 1

1

1

High-throughput

0.445

High

1088727

CEP63
Centrosomal protein of 63 kDa

1

1

High-throughput

0.445

High

1088756

DDX41
Probable ATP-dependent RNA helicase DDX41

1

1

High-throughput

0.445

High

476139

ANXA5
Annexin A5

1

1

High-throughput

0.437

High

929925

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

High-throughput

0.437

High

1088745

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

664864

RAE1
Rab proteins geranylgeranyltransferase component A 1

1

0

High-throughput

0.426

High

1088657

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

1088678

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.426

High

1088679

ODFP2
Outer dense fiber protein 2

1

0

High-throughput

0.426

High

1088686

ZN793
Zinc finger protein 793

1

0

High-throughput

0.426

High

1088696

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.426

High

1034437

TAGL
Transgelin

1

1

High-throughput

0.407

High

1088730

CK5P2
CDK5 regulatory subunit-associated protein 2

1

1

High-throughput

0.407

High

1088667

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

3

0

High-throughput

0.347

High

346986

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

389326

FINC
Fibronectin

1

0

High-throughput

0.279

Low

549580

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.279

Low

572818

NCF1
Neutrophil cytosol factor 1

1

0

High-throughput

0.279

Low

1088658

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.279

Low

1088688

NKAP1
Uncharacterized protein NKAPD1

1

0

High-throughput

0.279

Low

1088707

GPT11
G patch domain-containing protein 11

1

0

High-throughput

0.279

Low

1088750

HPBP1
Hsp70-binding protein 1

1

0

High-throughput

0.279

Low

297299

RGS9
Regulator of G-protein signaling 9

1

0

High-throughput

0.269

Low

1088712

JPH3
Junctophilin-3

1

0

High-throughput

0.268

Low

880910

MTR1B
Melatonin receptor type 1B

1

0

High-throughput

0.265

Low

422011

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.261

Low

272124

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

411828

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

877325

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.249

Low

995562

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.249

Low

1088661

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

1088701

SKA3
Spindle and kinetochore-associated protein 3

1

0

Small-scale

0.249

Low

1088705

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

1088737

ERP44
Endoplasmic reticulum resident protein 44

1

0

High-throughput

0.249

Low

62498

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low

87442

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low

133497

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.232

Low

1088676

UT2
Urea transporter 2

1

0

High-throughput

0.232

Low

1088682

NCLX
Mitochondrial sodium/calcium exchanger protein

1

0

High-throughput

0.232

Low

1088706

S35G3
Solute carrier family 35 member G3

1

0

High-throughput

0.232

Low

1088708

POC5
Centrosomal protein POC5

1

0

High-throughput

0.232

Low

1088724

S41A3
Solute carrier family 41 member 3

1

0

High-throughput

0.232

Low

1088743

S6A16
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025