HitPredict

Interactor 1: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Interactor 2: CKS2 (P33552)
Cyclin-dependent kinases regulatory subunit 2 (CKS-2)
Gene: CKS2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.969

Property	Details
Experiments	28514442, 33961781, 19786724, 25852190, 26186194, 26496610, 23455922
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CKS~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0007346 - regulation of mitotic cell cycle GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 298 Hs			1 79
+	Hs
		625283 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		CKS1_HUMAN (1-79): 1.09e-39: 127: 81.01
+	Hs
		895413 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		CKS1_HUMAN (1-79): 1.09e-39: 127: 81.01
+	Hs
		706796 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		CKS2_HUMAN (1-79): 8.58e-38: 122: 100.00
+	At
		621728 CDKA1_ARATH (1-289): 1.02e-144: 410: 68.62		CKS2_ARATH (5-78): 2.49e-39: 126: 66.22
+	Hs
		414843 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		CKS1_HUMAN (1-79): 1.09e-39: 127: 81.01
+	At
		188136 CDKA1_ARATH (1-289): 1.02e-144: 410: 68.62		CKS1_ARATH (5-73): 5.91e-38: 123: 68.12
+	Hs
		414778 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		CKS2_HUMAN (1-79): 8.58e-38: 122: 100.00
+	Hs
		895414 CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39		CKS1_HUMAN (1-79): 1.09e-39: 127: 81.01
+	Dm
		618415 CDK1_DROME (1-289): 1.85e-139: 396: 63.45		Q9VHN1_DROME (1-71): 3.94e-38: 123: 69.01
+	Hs
		706797 CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39		CKS2_HUMAN (1-79): 8.58e-38: 122: 100.00
+	At
		1321299 CDKD1_ARATH (2-298): 3.29e-134: 387: 47.48		CKS2_ARATH (5-78): 2.49e-39: 126: 66.22
+	Dm
		618387 CDK1_DROME (1-289): 1.85e-139: 396: 63.45		CKS1_DROME (3-72): 1.5e-35: 116: 77.14
+	At
		1103378 CKB12_ARATH (1-291): 3.9e-133: 381: 56.31		CKS2_ARATH (5-78): 2.49e-39: 126: 66.22
+	At
		1321252 CDKD2_ARATH (1-298): 2.18e-132: 380: 46.31		CKS2_ARATH (5-78): 2.49e-39: 126: 66.22
+	Dm
		618471 CDK2_DROME (1-289): 6.59e-134: 383: 63.67		Q9VHN1_DROME (1-71): 3.94e-38: 123: 69.01
+	At
		188147 CKB12_ARATH (1-291): 3.9e-133: 381: 56.31		CKS1_ARATH (5-73): 5.91e-38: 123: 68.12
+	At
		188163 CDKD2_ARATH (1-298): 2.18e-132: 380: 46.31		CKS1_ARATH (5-73): 5.91e-38: 123: 68.12
+	Dm
		618437 CDK2_DROME (1-289): 6.59e-134: 383: 63.67		CKS1_DROME (3-72): 1.5e-35: 116: 77.14
+	Sp
		383445 CDK1_SCHPO (1-290): 4.04e-137: 391: 65.32		CKS1_SCHPO (4-78): 2.51e-31: 107: 47.62
+	Sc
		339429 CDK1_YEAST (1-288): 3.57e-132: 378: 62.12		CKS1_YEAST (4-78): 2.01e-33: 113: 48.81