HitPredict

Interactor 1: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Interactor 2: MCM4 (P33991)
DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21)
Gene: MCM4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	10748114, 16519687
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006260 - DNA replication
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 298 Hs			1 863
+	Hs
		414780 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		MCM4_HUMAN (1-863): 0: 952: 100.00
+	Hs
		625235 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		MCM2_HUMAN (2-839): 0: 762: 27.95
+	Hs
		414822 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		MCM2_HUMAN (2-839): 0: 762: 27.95
+	Hs
		625435 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		MCM6_HUMAN (138-842): 0: 675: 26.97
+	Hs
		625168 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		MCM7_HUMAN (158-841): 0: 660: 29.88
+	Sc
		565493 PHO85_YEAST (3-290): 6.29e-131: 375: 54.88		MCM4_YEAST (1-862): 0: 745: 41.83
+	Sc
		565489 PHO85_YEAST (3-290): 6.29e-131: 375: 54.88		MCM2_YEAST (4-784): 0: 688: 26.05
+	Sc
		565490 PHO85_YEAST (3-290): 6.29e-131: 375: 54.88		MCM5_YEAST (156-840): 0: 688: 30.08
+	Hs
		708843 CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00		MCM7_HUMAN (158-841): 0: 660: 29.88