Protein: CYC
Cytochrome c

Gene: CYC, CYCS
Organism: Homo sapiens
Interactions: 195
UniProt ID: P99999

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005758 - mitochondrial intermembrane space
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

161712

APAF
Apoptotic protease-activating factor 1

3

0

Small-scale

0.803

High

1023601

COX42
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial

4

1

Small-scale

0.688

High

1023626

BRWD1
Bromodomain and WD repeat-containing protein 1

1

1

High-throughput

0.665

High

471641

CY1
Cytochrome c1, heme protein, mitochondrial

1

1

Small-scale

0.647

High

1023557

K1C40
Keratin, type I cytoskeletal 40

2

0

High-throughput

0.626

High

348465

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

3

High-throughput

0.618

High

505480

UCRIL
Putative cytochrome b-c1 complex subunit Rieske-like protein 1

1

3

High-throughput

0.618

High

1023604

PHB2
Prohibitin-2

2

1

High-throughput

0.601

High

667774

CDK2
Cyclin-dependent kinase 2

2

0

High-throughput

0.585

High

922723

CCHL
Holocytochrome c-type synthase

2

0

High-throughput

0.585

High

791292

SYUA
Alpha-synuclein

2

0

High-throughput

0.580

High

1023533

FP100
Fanconi anemia core complex-associated protein 100

2

0

High-throughput

0.576

High

1023577

FANCB
Fanconi anemia group B protein

2

0

High-throughput

0.576

High

1023595

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

0

High-throughput

0.576

High

1023551

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

2

High-throughput

0.571

High

371770

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.559

High

726751

TIA1
Cytotoxic granule associated RNA binding protein TIA1

2

0

Small-scale

0.559

High

2016

A0A0A0MR05
Target of rapamycin complex subunit LST8

1

0

High-throughput

0.556

High

988280

RAC1
Ras-related C3 botulinum toxin substrate 1

2

0

High-throughput

0.547

High

1023529

CAV1
Caveolin-1

2

0

High-throughput

0.547

High

1023569

CUL9
Cullin-9

1

0

Small-scale

0.537

High

180783

TIF1A
Transcription intermediary factor 1-alpha

1

2

High-throughput

0.536

High

213897

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

High-throughput

0.536

High

358882

AL1A1
Aldehyde dehydrogenase 1A1

1

1

High-throughput

0.536

High

529630

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.536

High

636068

CD11B
Cyclin-dependent kinase 11B

1

1

High-throughput

0.536

High

655152

SFPQ
Splicing factor, proline- and glutamine-rich

1

1

High-throughput

0.536

High

868079

AL1A3
Retinaldehyde dehydrogenase 3

1

1

High-throughput

0.536

High

875628

PRC2A
Protein PRRC2A

1

1

High-throughput

0.536

High

1023532

RBL2
Retinoblastoma-like protein 2

1

1

High-throughput

0.536

High

1023534

SFSWA
Splicing factor, suppressor of white-apricot homolog

1

1

High-throughput

0.536

High

1023578

RB15B
Putative RNA-binding protein 15B

1

1

High-throughput

0.536

High

1023585

PHF3
PHD finger protein 3

1

2

High-throughput

0.536

High

1023597

RBM33
RNA-binding protein 33

1

2

High-throughput

0.536

High

1023609

DIDO1
Death-inducer obliterator 1

1

3

High-throughput

0.536

High

1023615

NSRP1
Nuclear speckle splicing regulatory protein 1

1

2

High-throughput

0.536

High

1023631

CDK12
Cyclin-dependent kinase 12

1

2

High-throughput

0.536

High

1023633

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

1

High-throughput

0.536

High

1023639

ZO2
Tight junction protein 2

1

1

High-throughput

0.536

High

1023648

CBPC1
Cytosolic carboxypeptidase 1

1

0

High-throughput

0.518

High

766453

PHB1
Prohibitin 1

1

1

High-throughput

0.515

High

1023558

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.515

High

629099

CCNA2
Cyclin-A2

1

0

High-throughput

0.513

High

1023530

KPCZ
Protein kinase C zeta type

1

0

High-throughput

0.513

High

1023535

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

0

High-throughput

0.513

High

1023550

HABP4
Intracellular hyaluronan-binding protein 4

1

0

High-throughput

0.513

High

1023565

DDX46
Probable ATP-dependent RNA helicase DDX46

1

0

High-throughput

0.513

High

1023567

LYRIC
Protein LYRIC

1

0

High-throughput

0.513

High

1023574

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

0

High-throughput

0.513

High

1023576

PR38A
Pre-mRNA-splicing factor 38A

1

0

High-throughput

0.513

High

1023579

RP9
Retinitis pigmentosa 9 protein

1

0

High-throughput

0.513

High

1023580

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.513

High

1023583

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.513

High

1023586

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

0

High-throughput

0.513

High

1023600

RSRC1
Serine/Arginine-related protein 53

1

0

High-throughput

0.513

High

1023610

DCNL5
DCN1-like protein 5

1

0

High-throughput

0.513

High

1023620

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.513

High

1023624

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.513

High

1023628

FANCL
E3 ubiquitin-protein ligase FANCL

1

0

High-throughput

0.513

High

1023629

ARGL1
Arginine and glutamate-rich protein 1

1

0

High-throughput

0.513

High

1023630

CWC25
Pre-mRNA-splicing factor CWC25 homolog

1

0

High-throughput

0.513

High

1023634

RBM27
RNA-binding protein 27

1

0

High-throughput

0.513

High

1023646

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.513

High

1023647

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

0

High-throughput

0.513

High

1023651

UTP11
Probable U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.513

High

357935

CYB5
Cytochrome b5

1

1

Small-scale

0.501

High

596640

NCPR
NADPH--cytochrome P450 reductase

1

1

Small-scale

0.501

High

728754

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

2

Small-scale

0.501

High

1023643

NDOR1
NADPH-dependent diflavin oxidoreductase 1

1

1

Small-scale

0.501

High

1023649

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.493

High

131402

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

0

High-throughput

0.493

High

229321

ZBT14
Zinc finger and BTB domain-containing protein 14

1

0

High-throughput

0.493

High

421927

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.493

High

440493

FYN
Tyrosine-protein kinase Fyn

1

0

High-throughput

0.493

High

1023538

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.493

High

1023548

FX4L6
Forkhead box protein D4-like 6

1

0

High-throughput

0.493

High

1023588

SYMPK
Symplekin

1

0

High-throughput

0.493

High

1023591

COA7
Cytochrome c oxidase assembly factor 7

1

0

High-throughput

0.493

High

1023611

PHF23
PHD finger protein 23

1

0

High-throughput

0.493

High

1023645

OCTC
Peroxisomal carnitine O-octanoyltransferase

1

0

High-throughput

0.493

High

704940

RBL1
Retinoblastoma-like protein 1

1

1

High-throughput

0.489

High

889078

RBM25
RNA-binding protein 25

1

1

High-throughput

0.489

High

1023542

ELOA1
Elongin-A

1

3

High-throughput

0.489

High

1023566

RSRC2
Arginine/serine-rich coiled-coil protein 2

1

1

High-throughput

0.489

High

893818

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

536971

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.480

High

143827

NDKM
Nucleoside diphosphate kinase, mitochondrial

1

1

High-throughput

0.479

High

190139

TNC18
Trinucleotide repeat-containing gene 18 protein

1

1

High-throughput

0.479

High

241406

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

328371

NDUB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

1

1

High-throughput

0.479

High

415502

HSPB1
Heat shock protein beta-1

1

2

Small-scale

0.479

High

606631

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

659443

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.479

High

828642

MDHC
Malate dehydrogenase, cytoplasmic

1

1

High-throughput

0.479

High

830567

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

904601

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.479

High

912550

GDIR1
Rho GDP-dissociation inhibitor 1

1

1

High-throughput

0.479

High

934465

TERA
Transitional endoplasmic reticulum ATPase

1

1

Small-scale

0.479

High

987329

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

1

Small-scale

0.479

High

1004451

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

1023536

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

1023541

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

1023543

NONO
Non-POU domain-containing octamer-binding protein

1

3

High-throughput

0.479

High

1023545

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

1023592

OPTN
Optineurin

1

1

High-throughput

0.479

High

1023612

MIC26
MICOS complex subunit MIC26

1

1

High-throughput

0.479

High

1023614

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

1023632

GMIP
GEM-interacting protein

1

1

High-throughput

0.479

High

1023644

TNIK
TRAF2 and NCK-interacting protein kinase

1

1

High-throughput

0.479

High

1023654

TRAF6
TNF receptor-associated factor 6

1

1

High-throughput

0.479

High

1023553

PR38B
Pre-mRNA-splicing factor 38B

1

3

High-throughput

0.470

High

1023546

LONF2
LON peptidase N-terminal domain and RING finger protein 2

1

1

High-throughput

0.470

High

1023575

KCD17
BTB/POZ domain-containing protein KCTD17

1

1

High-throughput

0.470

High

350848

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

377205

SOMA
Somatotropin

1

0

High-throughput

0.458

High

402763

CYTB
Cystatin-B

1

0

High-throughput

0.458

High

538946

EPB41
Protein 4.1

1

0

High-throughput

0.458

High

565348

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

588471

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

695220

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

822609

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

875917

TCPE
T-complex protein 1 subunit epsilon

1

0

High-throughput

0.458

High

915944

NUP98
Nuclear pore complex protein Nup98-Nup96

1

0

High-throughput

0.458

High

946401

MTPN
Myotrophin

1

0

High-throughput

0.458

High

957710

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

High-throughput

0.458

High

983267

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.458

High

1013379

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

1023531

B2CL1
Bcl-2-like protein 1

1

0

Small-scale

0.458

High

1023537

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1023539

DX39B
Spliceosome RNA helicase DDX39B

1

0

High-throughput

0.458

High

1023540

PDE1C
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

1

0

High-throughput

0.458

High

1023544

ELAV1
ELAV-like protein 1

1

0

Small-scale

0.458

High

1023549

MIX23
Protein MIX23

1

0

High-throughput

0.458

High

1023552

MRCKA
Serine/threonine-protein kinase MRCK alpha

1

0

High-throughput

0.458

High

1023554

MIC13
MICOS complex subunit MIC13

1

0

High-throughput

0.458

High

1023556

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1023559

ETFR1
Electron transfer flavoprotein regulatory factor 1

1

0

High-throughput

0.458

High

1023568

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1023571

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1023581

SPT20
Spermatogenesis-associated protein 20

1

0

High-throughput

0.458

High

1023582

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

0

High-throughput

0.458

High

1023584

TITIN
Titin

1

0

High-throughput

0.458

High

1023590

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.458

High

1023594

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.458

High

1023598

FMC1
Protein FMC1 homolog

1

0

High-throughput

0.458

High

1023602

IMP1L
Mitochondrial inner membrane protease subunit 1

1

0

High-throughput

0.458

High

1023603

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

0

High-throughput

0.458

High

1023605

COQ7
NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial

1

0

High-throughput

0.458

High

1023606

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

1023616

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

1023618

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1023619

CQ10B
Coenzyme Q-binding protein COQ10 homolog B, mitochondrial

1

0

High-throughput

0.458

High

1023621

SFXN1
Sideroflexin-1

1

0

High-throughput

0.458

High

1023622

SUCHY
Succinyl-CoA:glutarate CoA-transferase

1

0

High-throughput

0.458

High

1023623

PPA6
Lysophosphatidic acid phosphatase type 6

1

0

High-throughput

0.458

High

1023625

ARHG4
Rho guanine nucleotide exchange factor 4

1

0

High-throughput

0.458

High

1023637

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.458

High

1023638

DJB11
DnaJ homolog subfamily B member 11

1

0

High-throughput

0.458

High

1023640

TRM7
tRNA

1

0

High-throughput

0.458

High

1023641

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1023642

TES
Testin

1

0

High-throughput

0.458

High

1023650

COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

1

0

High-throughput

0.458

High

1023652

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

1023653

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

640851

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

2

Small-scale

0.445

High

1023560

ATAD2
ATPase family AAA domain-containing protein 2

1

2

High-throughput

0.445

High

583535

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

0

High-throughput

0.426

High

1023587

ESR2
Estrogen receptor beta

1

0

High-throughput

0.426

High

619741

VCAM1
Vascular cell adhesion protein 1

1

1

High-throughput

0.407

High

388861

A2GL
Leucine-rich alpha-2-glycoprotein

2

0

High-throughput

0.328

High

1023607

SH3G3
Endophilin-A3

2

0

High-throughput

0.298

High

1023564

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

0

Small-scale

0.292

High

1023570

SUGP1
SURP and G-patch domain-containing protein 1

1

0

High-throughput

0.279

Low

1023593

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.279

Low

1023596

RRP36
Ribosomal RNA processing protein 36 homolog

1

0

High-throughput

0.279

Low

1023608

SELS
Selenoprotein S

1

0

High-throughput

0.279

Low

1023617

ESF1
ESF1 homolog

1

0

High-throughput

0.279

Low

1023547

CC036
Uncharacterized protein C3orf36

1

0

High-throughput

0.268

Low

1023555

RUAS1
Putative uncharacterized protein RUSC1-AS1

1

0

High-throughput

0.268

Low

1023561

ASCL4
Achaete-scute homolog 4

1

0

High-throughput

0.268

Low

1023562

PPR21
Protein phosphatase 1 regulatory subunit 21

1

0

High-throughput

0.268

Low

1023572

LRC56
Leucine-rich repeat-containing protein 56

1

0

High-throughput

0.268

Low

1023573

FAM9A
Protein FAM9A

1

0

High-throughput

0.268

Low

1023627

SEM4G
Semaphorin-4G

1

0

High-throughput

0.268

Low

65527

DDTL
D-dopachrome decarboxylase-like protein

1

0

High-throughput

0.249

Low

105761

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

276771

TBCA
Tubulin-specific chaperone A

1

0

High-throughput

0.249

Low

380003

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.249

Low

767963

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1023563

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1023589

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.249

Low

1023599

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1023635

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.249

Low

1023636

TR10D
Tumor necrosis factor receptor superfamily member 10D

1

0

High-throughput

0.249

Low

1023613

S46A2
Solute carrier family 46 member 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025