HitPredict

Interactor 1: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Interactor 2: CDN1A (P38936)
Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)
Gene: CDKN1A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.997

The method score is based on:

Property Details
Experiments 26186194, 26496610, 28514442, 27215384, 24407240, 12417722, 8242751, 33961781, 9858587, 11521189, 23737759, 15647383, 15557281, 20587660, 18850315, 12949733, 12800980, 10918595, 10874474, 9658399 and 41 others

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Identification Methods affinity chromatography technology, two hybrid, pull down, enzymatic study, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, mammalian protein protein interaction trap, lexa b52 complementation, tandem affinity purification, surface plasmon resonance and 1 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains CDI~Pkinase
Common GO terms GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
and 5 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 298
Hs

1 164
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Last updated: 15 Jul 2024