HitPredict

Interactor 1: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Interactor 2: E2F1 (Q01094)
Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1)
Gene: E2F1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.85 0.60 0.717

The method score is based on:

Property Details
Experiments 7969176, 11245432, 1530885, 8458319, 9199321
Identification Methods pull down, enzymatic study, affinity chromatography technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
and 3 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 298
Hs

1 437
+ Hs
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+ At
+ At
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+ Mm
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+ Dm
+ At
+ Zm
+ At
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024