Protein: NACA
Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) (allergen Hom s 2)

Gene: NACA
Organism: Homo sapiens
Interactions: 206
UniProt ID: Q13765

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003231 - cardiac ventricle development
GO:0003677 - DNA binding
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

629848

BTF3
Transcription factor BTF3

15

20

Small-scale

0.981

High

1117128

BT3L4
Transcription factor BTF3 homolog 4

9

20

Small-scale

0.863

High

241630

PRKN
E3 ubiquitin-protein ligase parkin

3

1

High-throughput

0.656

High

176768

NACAD
NAC-alpha domain-containing protein 1

1

5

High-throughput

0.618

High

135614

DNM1L
Dynamin-1-like protein

2

1

High-throughput

0.611

High

247887

NUPR1
Nuclear protein 1

3

0

Small-scale

0.609

High

1096895

FADD
FAS-associated death domain protein

2

0

Small-scale

0.598

High

429856

JUN
Transcription factor Jun

2

2

Small-scale

0.597

High

821102

TXLNA
Alpha-taxilin

1

6

High-throughput

0.586

High

1113055

CUL3
Cullin-3

2

0

High-throughput

0.585

High

1117151

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

2

0

High-throughput

0.585

High

371977

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.584

High

1117145

NACA2
Nascent polypeptide-associated complex subunit alpha-2

1

4

Small-scale

0.575

High

396073

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

1117111

RHG24
Rho GTPase-activating protein 24

2

1

High-throughput

0.571

High

1117100

PPR18
Phostensin

1

2

Small-scale

0.561

High

998297

H31
Histone H3.1

2

0

High-throughput

0.559

High

1117086

PLEC
Plectin

2

0

High-throughput

0.559

High

967718

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

Small-scale

0.554

High

1117135

FUND2
FUN14 domain-containing protein 2

1

1

High-throughput

0.541

High

361244

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

484524

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.536

High

583548

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

1

High-throughput

0.536

High

591639

H2AX
Histone H2AX

1

1

High-throughput

0.536

High

625370

CSK22
Casein kinase II subunit alpha'

1

3

High-throughput

0.536

High

861602

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

4

High-throughput

0.536

High

867108

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

1117131

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.536

High

1117156

SMYD2
N-lysine methyltransferase SMYD2

1

2

High-throughput

0.536

High

1117163

ZHX1
Zinc fingers and homeoboxes protein 1

1

0

High-throughput

0.518

High

422077

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.515

High

389347

FINC
Fibronectin

1

0

High-throughput

0.513

High

908395

HDGF
Hepatoma-derived growth factor

1

0

High-throughput

0.513

High

1117152

ENY2
Transcription and mRNA export factor ENY2

1

0

High-throughput

0.513

High

1117170

EMC9
ER membrane protein complex subunit 9

1

0

High-throughput

0.513

High

370661

FOS
Protein c-Fos

1

2

Small-scale

0.501

High

1117173

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

2

Small-scale

0.501

High

907270

STA5B
Signal transducer and activator of transcription 5B

1

1

High-throughput

0.500

High

907314

APLP1
Amyloid beta precursor like protein 1

1

1

High-throughput

0.494

High

559685

UNG
Uracil-DNA glycosylase

1

0

High-throughput

0.493

High

951665

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

High-throughput

0.480

High

65908

RHG42
Rho GTPase-activating protein 42

1

1

High-throughput

0.479

High

132023

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

3

High-throughput

0.479

High

135204

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

1

High-throughput

0.479

High

247318

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

2

High-throughput

0.479

High

259921

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

271518

ATG13
Autophagy-related protein 13

1

1

High-throughput

0.479

High

323365

TRI37
E3 ubiquitin-protein ligase TRIM37

1

3

High-throughput

0.479

High

400804

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

406157

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

425490

ISG15
Ubiquitin-like protein ISG15

1

3

High-throughput

0.479

High

507948

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.479

High

547606

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

1

High-throughput

0.479

High

588652

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

606741

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

616178

PGAM1
Phosphoglycerate mutase 1

1

1

High-throughput

0.479

High

656117

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

2

High-throughput

0.479

High

693731

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.479

High

698643

CALX
Calnexin

1

1

High-throughput

0.479

High

699740

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

2

High-throughput

0.479

High

712203

TKT
Transketolase

1

1

High-throughput

0.479

High

715576

MARCS
Myristoylated alanine-rich C-kinase substrate

1

2

High-throughput

0.479

High

717302

PEBP1
Phosphatidylethanolamine-binding protein 1

1

1

High-throughput

0.479

High

799091

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

842364

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.479

High

854845

RECQ1
ATP-dependent DNA helicase Q1

1

1

High-throughput

0.479

High

891530

GSK3B
Glycogen synthase kinase-3 beta

1

4

High-throughput

0.479

High

929937

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

High-throughput

0.479

High

930306

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

1

High-throughput

0.479

High

930695

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

1

High-throughput

0.479

High

957368

UBC12
NEDD8-conjugating enzyme Ubc12

1

2

High-throughput

0.479

High

964267

SUMO2
Small ubiquitin-related modifier 2

1

3

High-throughput

0.479

High

970467

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

984753

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.479

High

986413

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

997701

CSK21
Casein kinase II subunit alpha

1

7

High-throughput

0.479

High

1010294

BASP1
Brain acid soluble protein 1

1

2

High-throughput

0.479

High

1024562

VIGLN
Vigilin

1

3

High-throughput

0.479

High

1026884

FKBP3
Peptidyl-prolyl cis-trans isomerase FKBP3

1

5

High-throughput

0.479

High

1095990

TADBP
TAR DNA-binding protein 43

1

2

High-throughput

0.479

High

1096680

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

1117083

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

1117084

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1117087

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.479

High

1117088

PCBP1
Poly(rC)-binding protein 1

1

1

Small-scale

0.479

High

1117091

LARP7
La-related protein 7

1

1

High-throughput

0.479

High

1117093

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.479

High

1117103

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1117105

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

4

High-throughput

0.479

High

1117110

RPTOR
Regulatory-associated protein of mTOR

1

1

High-throughput

0.479

High

1117119

LMO7
LIM domain only protein 7

1

2

Small-scale

0.479

High

1117122

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

1117123

HS105
Heat shock protein 105 kDa

1

3

High-throughput

0.479

High

1117124

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

1117125

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.479

High

1117132

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

1117133

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

2

High-throughput

0.479

High

1117136

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

1117138

TRI55
Tripartite motif-containing protein 55

1

3

High-throughput

0.479

High

1117139

TRI31
E3 ubiquitin-protein ligase TRIM31

1

2

High-throughput

0.479

High

1117140

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

2

High-throughput

0.479

High

1117141

RHG39
Rho GTPase-activating protein 39

1

1

High-throughput

0.479

High

1117142

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.479

High

1117148

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

1117154

BRD7
Bromodomain-containing protein 7

1

1

High-throughput

0.479

High

1117157

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

High-throughput

0.479

High

1117158

HDAC6
Protein deacetylase HDAC6

1

1

High-throughput

0.479

High

1117159

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1117161

FBW1B
F-box/WD repeat-containing protein 11

1

2

High-throughput

0.479

High

1117166

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.479

High

1117167

FAF1
FAS-associated factor 1

1

1

High-throughput

0.479

High

1117171

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

1117172

MB212
Protein mab-21-like 2

1

1

High-throughput

0.479

High

1117174

RBM8A
RNA-binding protein 8A

1

2

High-throughput

0.479

High

522264

OSTP
Osteopontin

1

0

Small-scale

0.460

High

1028191

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

High-throughput

0.460

High

135805

RTCA
RNA 3'-terminal phosphate cyclase

1

0

High-throughput

0.458

High

171240

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

0

Small-scale

0.458

High

223018

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

238514

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

254135

CTND1
Catenin delta-1

1

0

Small-scale

0.458

High

293668

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

302513

RNF8
E3 ubiquitin-protein ligase RNF8

1

0

High-throughput

0.458

High

319747

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

324848

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

336417

SVIL
Supervillin

1

0

Small-scale

0.458

High

537127

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

593663

BGAL
Beta-galactosidase

1

0

Small-scale

0.458

High

599588

STMN1
Stathmin

1

0

High-throughput

0.458

High

635793

PTMS
Parathymosin

1

0

High-throughput

0.458

High

695412

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

772158

MSX2
Homeobox protein MSX-2

1

0

High-throughput

0.458

High

876586

NEST
Nestin

1

0

Small-scale

0.458

High

879067

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

888046

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

922812

ITA8
Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

1

0

High-throughput

0.458

High

961720

RL37A
Large ribosomal subunit protein eL43

1

0

High-throughput

0.458

High

964931

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.458

High

1013989

RL36A
Large ribosomal subunit protein eL42

1

0

High-throughput

0.458

High

1032952

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

1039206

RL6
Large ribosomal subunit protein eL6

1

0

High-throughput

0.458

High

1067306

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

1085542

FOXO1
Forkhead box protein O1

1

0

High-throughput

0.458

High

1096536

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

1106837

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1117079

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.458

High

1117085

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1117089

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1117090

CDC37
Hsp90 co-chaperone Cdc37

1

0

Small-scale

0.458

High

1117096

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.458

High

1117097

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1117098

CYTSA
Cytospin-A

1

0

Small-scale

0.458

High

1117104

DPPA4
Developmental pluripotency-associated protein 4

1

0

High-throughput

0.458

High

1117106

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1117108

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

1

0

High-throughput

0.458

High

1117109

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.458

High

1117113

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1117116

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.458

High

1117117

MORC4
MORC family CW-type zinc finger protein 4

1

0

High-throughput

0.458

High

1117120

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.458

High

1117121

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

1117126

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1117129

NEB2
Neurabin-2

1

0

Small-scale

0.458

High

1117130

PARK7
Parkinson disease protein 7

1

0

High-throughput

0.458

High

1117137

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

1117144

EGLN1
Egl nine homolog 1

1

0

Small-scale

0.458

High

1117147

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

1117149

RC3H2
Roquin-2

1

0

High-throughput

0.458

High

1117150

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

1117160

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

1117168

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.458

High

529766

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

1117099

PKHA7
Pleckstrin homology domain-containing family A member 7

1

5

High-throughput

0.445

High

1117095

RIF1
Telomere-associated protein RIF1

1

0

High-throughput

0.438

High

411899

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

566662

PDIA4
Protein disulfide-isomerase A4

1

4

High-throughput

0.437

High

1117080

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

3

High-throughput

0.437

High

1117081

RBM39
RNA-binding protein 39

1

1

High-throughput

0.437

High

1117107

ZCH18
Zinc finger CCCH domain-containing protein 18

1

2

High-throughput

0.437

High

1117112

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

1117114

FXL13
F-box and leucine-rich repeat protein 13

1

1

Small-scale

0.437

High

1117115

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.437

High

1117134

PBDC1
Protein PBDC1

1

2

Small-scale

0.437

High

1117164

PKHG1
Pleckstrin homology domain-containing family G member 1

1

1

High-throughput

0.437

High

1117165

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.437

High

1117169

NINL
Ninein-like protein

1

1

High-throughput

0.437

High

244970

KATIP
Katanin-interacting protein

1

0

High-throughput

0.426

High

294702

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.426

High

344189

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.426

High

619783

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.426

High

994528

YBOX1
Y-box-binding protein 1

1

0

High-throughput

0.426

High

1117092

Q5JYA6
PLEKHG1

1

1

High-throughput

0.407

High

1117127

IGS21
Immunoglobulin superfamily member 21

1

0

High-throughput

0.282

High

1117143

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

0

High-throughput

0.282

High

1117082

CND2
Condensin complex subunit 2

1

0

High-throughput

0.279

Low

1117094

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.251

Low

157344

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

318766

RHBT1
Rho-related BTB domain-containing protein 1

1

0

High-throughput

0.249

Low

768143

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1117101

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.249

Low

1117118

NOC3L
Nucleolar complex protein 3 homolog

1

0

High-throughput

0.249

Low

1117153

NGB
Neuroglobin

1

0

High-throughput

0.249

Low

1117155

ANLN
Anillin

1

0

High-throughput

0.249

Low

1117162

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.249

Low

1117102

SHLD3
Shieldin complex subunit 3

1

0

High-throughput

0.232

Low

1117146

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025