HitPredict

Interactor 1: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Interactor 2: E2F4 (Q16254)
Transcription factor E2F4 (E2F-4)
Gene: E2F4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	25852190, 33961781, 35253629
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0019904 - protein domain specific binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 298 Hs			1 413
+	Mm
		509489 CDK1_MOUSE (1-289): 8.74e-143: 405: 66.21		E2F4_MOUSE (1-413): 4.62e-177: 501: 92.03
+	At
		621698 CDKA1_ARATH (1-289): 1.02e-144: 410: 68.62		E2FA_ARATH (3-298): 3.72e-103: 316: 35.33
+	Hs
		625370 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		E2F1_HUMAN (10-278): 8.99e-81: 257: 35.29
+	At
		1103370 CKB12_ARATH (1-291): 3.9e-133: 381: 56.31		E2FA_ARATH (3-298): 3.72e-103: 316: 35.33
+	At
		1321247 CDKD2_ARATH (1-298): 2.18e-132: 380: 46.31		E2FA_ARATH (3-298): 3.72e-103: 316: 35.33
+	Hs
		414867 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		E2F1_HUMAN (10-278): 8.99e-81: 257: 35.29
+	At
		621702 CDKA1_ARATH (1-289): 1.02e-144: 410: 68.62		E2FC_ARATH (1-226): 4.63e-77: 245: 41.30
+	At
		1106227 MPK3_ARATH (9-296): 7.89e-131: 377: 34.92		E2FC_ARATH (1-226): 4.63e-77: 245: 41.30
+	At
		1228088 CKB22_ARATH (1-294): 8.52e-131: 375: 55.45		E2FC_ARATH (1-226): 4.63e-77: 245: 41.30
+	Hs
		841169 CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00		E2F1_HUMAN (10-278): 8.99e-81: 257: 35.29
+	Hs
		625450 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		E2F5_HUMAN (304-412): 2.39e-35: 134: 39.34
+	Dm
		618391 CDK1_DROME (1-289): 1.85e-139: 396: 63.45		E2F1_DROME (13-207): 3.06e-55: 196: 38.19
+	At
		621680 CDKA1_ARATH (1-289): 1.02e-144: 410: 68.62		E2FE_ARATH (6-137): 2.81e-17: 84.9: 29.25
+	Zm
		80074 B6TCF2_MAIZE (3-297): 1.83e-130: 376: 36.76		K7U648_MAIZE (17-138): 5.36e-22: 99.1: 27.94
+	At
		639352 CKB11_ARATH (1-291): 1.3e-124: 359: 56.03		E2FE_ARATH (6-137): 2.81e-17: 84.9: 29.25
+	At
		639353 CKB11_ARATH (1-291): 1.3e-124: 359: 56.03		E2FF_ARATH (7-140): 2.01e-15: 79.1: 22.93