HitPredict

Interactor 1: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Interactor 2: MK15 (Q8TD08)
Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8)
Gene: MAPK15

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.932

Property	Details
Experiments	25852190, 26186194, 28514442, 33961781, 23455922
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~Pkinase
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0008284 - positive regulation of cell population proliferation and 1 others more... GO:0106310 - protein serine kinase activity
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 298 Hs			1 544
+	Hs
		960312 CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39		MK15_HUMAN (1-544): 0: 545: 100.00
+	Hs
		625115 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		CDK2_HUMAN (10-315): 6.34e-141: 410: 38.31
+	Hs
		625363 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		CDK3_HUMAN (10-316): 8.82e-136: 397: 38.19
+	Hs
		414746 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		CDK2_HUMAN (10-315): 6.34e-141: 410: 38.31
+	Hs
		414864 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		CDK3_HUMAN (10-316): 8.82e-136: 397: 38.19
+	Hs
		625365 CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39		CDK2_HUMAN (10-315): 6.34e-141: 410: 38.31
+	At
		1106290 MPK4_ARATH (7-296): 1.63e-132: 382: 38.05		MPK4_ARATH (16-351): 2.36e-143: 419: 43.95
+	Hs
		960080 CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39		CDK3_HUMAN (10-316): 8.82e-136: 397: 38.19
+	At
		1105932 MPK4_ARATH (7-296): 1.63e-132: 382: 38.05		MPK1_ARATH (12-356): 2.65e-138: 406: 37.93
+	At
		1106155 MPK3_ARATH (9-296): 7.89e-131: 377: 34.92		MPK3_ARATH (7-351): 1.03e-139: 410: 40.69
+	At
		1106434 CKB21_ARATH (1-294): 1.78e-131: 377: 54.13		MPK5_ARATH (7-348): 5.9e-140: 410: 41.33
+	At
		1105931 MPK3_ARATH (9-296): 7.89e-131: 377: 34.92		MPK1_ARATH (12-356): 2.65e-138: 406: 37.93
+	At
		1105962 CKB21_ARATH (1-294): 1.78e-131: 377: 54.13		MPK1_ARATH (12-356): 2.65e-138: 406: 37.93
+	At
		1106234 MPK3_ARATH (9-296): 7.89e-131: 377: 34.92		CDKC1_ARATH (4-471): 4.79e-136: 405: 25.05
+	Dm
		618429 CDK2_DROME (1-289): 6.59e-134: 383: 63.67		ERKA_DROME (12-355): 2.42e-133: 394: 40.63
+	Hs
		625243 CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00		CDK2_HUMAN (10-315): 6.34e-141: 410: 38.31
+	Hs
		625366 CDK16_HUMAN (1-286): 4.1e-107: 322: 55.40		CDK2_HUMAN (10-315): 6.34e-141: 410: 38.31
+	Hs
		414751 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		MK03_HUMAN (12-313): 8.66e-78: 251: 45.25
+	Sc
		339792 CDK1_YEAST (1-288): 3.57e-132: 378: 62.12		SLT2_YEAST (6-313): 5.04e-75: 247: 42.36