Protein: DOT1
Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (Disrupter of telomere silencing protein 1) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4)

Gene: DOT1
Organism: Saccharomyces cerevisiae S288C
Interactions: 31
UniProt ID: Q04089

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0000725 - recombinational repair
GO:0000781 - chromosome, telomeric region
GO:0000786 - nucleosome
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

963698

H3
Histone H3

9

4

Small-scale

0.973

High

382319

H4
Histone H4

4

0

Small-scale

0.844

High

381245

H2B1
Histone H2B.1

2

3

Small-scale

0.755

High

509707

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

0

Small-scale

0.687

High

381623

H2B2
Histone H2B.2

1

3

Small-scale

0.647

High

419497

H2A1
Histone H2A.1

1

2

Small-scale

0.647

High

419861

H2A2
Histone H2A.2

1

2

Small-scale

0.647

High

1045019

DOT1
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.575

High

781157

SWD2
COMPASS component SWD2

1

6

Small-scale

0.515

High

1045024

YRA1
RNA annealing protein YRA1

1

4

High-throughput

0.515

High

795918

LSM2
LSM complex subunit LSM2

1

1

High-throughput

0.508

High

599403

FUS3
Mitogen-activated protein kinase FUS3

1

2

High-throughput

0.501

High

737943

HOG1
Mitogen-activated protein kinase HOG1

1

2

Small-scale

0.501

High

656611

KC11
Casein kinase I homolog 1

1

0

High-throughput

0.480

High

1045020

CORO
Coronin-like protein

1

3

High-throughput

0.470

High

1045021

IMH1
Golgin IMH1

1

3

High-throughput

0.470

High

1045022

RRS1
Regulator of ribosome biosynthesis

1

1

High-throughput

0.470

High

708087

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

1045023

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

525047

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.445

High

527596

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

546154

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

742327

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.445

High

807134

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.426

High

580009

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.407

High

816385

HSP7E
Heat shock protein SSC3, mitochondrial

1

1

High-throughput

0.407

High

825331

SLM1
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1

1

0

High-throughput

0.269

Low

898914

INP52
Polyphosphatidylinositol phosphatase INP52

1

0

High-throughput

0.269

Low

863722

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

1045025

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025