HitPredict

Interactor 1: ARBK1 (P25098)
Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2)
Gene: GRK2

Interactor 2: GBB2 (P62879)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2)
Gene: GNB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	25982117, 37689310
Identification Methods	enzymatic study, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~WD40, RGS~WD40
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway GO:0016020 - membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 689 Hs			1 340
+	Hs
		560859 ARBK1_HUMAN (1-689): 0: 654: 100.00		GBB3_HUMAN (1-340): 2.27e-106: 316: 80.88
+	Hs
		626636 ARBK1_HUMAN (1-689): 0: 654: 100.00		GBB1_HUMAN (1-340): 1.35e-106: 316: 90.29
+	Mm
		921105 ARBK1_MOUSE (1-689): 0: 653: 98.84		GBB1_MOUSE (1-340): 1.35e-106: 316: 90.29
+	Hs
		682161 AKT2_HUMAN (68-517): 4.7e-142: 425: 27.96		GBB1_HUMAN (1-340): 1.35e-106: 316: 90.29
+	Hs
		681771 AKT1_HUMAN (68-515): 3.49e-140: 420: 26.41		GBB1_HUMAN (1-340): 1.35e-106: 316: 90.29
+	Hs
		196956 ARBK1_HUMAN (1-689): 0: 654: 100.00		PRP4_HUMAN (51-253): 4.41e-11: 65.9: 24.88
+	Dm
		640819 GPRK2_DROME (144-524): 5.69e-79: 268: 41.43		GBB1_DROME (1-340): 1.91e-106: 316: 81.47
+	Dm
		1213409 AKT1_DROME (140-511): 3.33e-137: 417: 28.95		NLE_DROME (131-339): 2.1e-46: 165: 22.57
+	Dm
		669785 GPRK2_DROME (144-524): 5.69e-79: 268: 41.43		GBB2_DROME (137-340): 2.06e-41: 149: 21.33