HitPredict

Interactor 1: EDNRA (P25101)
Endothelin-1 receptor (Endothelin receptor type A) (ET-A) (ETA-R) (hET-AR)
Gene: EDNRA

Interactor 2: ARRB2 (P32121)
Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3)
Gene: ARRB2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	19202075
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	7tm_1~Arrestin_C, 7tm_1~Arrestin_N
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 427 Hs			1 409
+	Hs
		626701 EDNRA_HUMAN (1-427): 1.1e-93: 290: 100.00		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Mm
		1142952 EDNRA_MOUSE (1-427): 2.93e-92: 286: 92.27		ARRB1_MOUSE (1-399): 0: 652: 76.90
+	Hs
		428933 ADRB2_HUMAN (48-411): 7.71e-74: 238: 17.05		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Rn
		663954 Q8VBU7_RAT (51-414): 6.53e-73: 236: 18.46		ARRB2_RAT (1-409): 0: 682: 95.85
+	Hs
		674827 AGTR1_HUMAN (67-421): 2.59e-71: 230: 20.00		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Hs
		685822 OPRD_HUMAN (34-414): 1.45e-68: 223: 20.37		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Hs
		441648 ADRB1_HUMAN (25-406): 5.47e-67: 222: 15.78		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Hs
		685813 APJ_HUMAN (71-412): 6.25e-67: 219: 22.03		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Rn
		626614 AGTRA_RAT (69-422): 1.72e-64: 212: 18.64		ARRB2_RAT (1-409): 0: 682: 95.85
+	Hs
		674834 AGTR1_HUMAN (67-421): 2.59e-71: 230: 20.00		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Mm
		669680 AGTRA_MOUSE (67-422): 2.62e-72: 232: 19.10		ARRB1_MOUSE (1-399): 0: 652: 76.90
+	Hs
		781016 OPRD_HUMAN (34-414): 1.45e-68: 223: 20.37		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Hs
		441649 ADRB1_HUMAN (25-406): 5.47e-67: 222: 15.78		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Rn
		626613 AGTRA_RAT (69-422): 1.72e-64: 212: 18.64		ARRB1_RAT (1-399): 0: 654: 76.90
+	Hs
		176005 GPR37_HUMAN (81-380): 6.03e-28: 118: 24.44		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Hs
		208441 OX1R_HUMAN (95-387): 2.95e-16: 82: 23.81		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Hs
		208444 OX1R_HUMAN (95-387): 2.95e-16: 82: 23.81		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Hs
		626815 ACKR3_HUMAN (69-377): 9.66e-16: 80.1: 22.57		ARRB1_HUMAN (1-407): 0: 661: 76.15