Protein: S12A2
Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2)

Gene: S12A2, SLC12A2
Organism: Homo sapiens
Interactions: 188
UniProt ID: P55011

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0006811 - monoatomic ion transport
GO:0006883 - intracellular sodium ion homeostasis
GO:0006884 - cell volume homeostasis
GO:0006972 - hyperosmotic response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

572325

LEG3
Galectin-3

4

20

Small-scale

0.694

High

350004

RASK
GTPase KRas

4

20

High-throughput

0.676

High

121133

LEG8
Galectin-8

3

20

High-throughput

0.667

High

654202

CALX
Calnexin

3

5

High-throughput

0.657

High

348593

RASN
GTPase NRas

3

20

High-throughput

0.640

High

349223

RASH
GTPase HRas

3

14

High-throughput

0.640

High

546988

EZRI
Ezrin

3

2

Small-scale

0.640

High

119282

LEG9
Galectin-9

4

20

High-throughput

0.633

High

793176

PI2R
Prostacyclin receptor

2

6

High-throughput

0.628

High

802316

5HT3A
5-hydroxytryptamine receptor 3A

2

4

High-throughput

0.628

High

873953

RN149
E3 ubiquitin-protein ligase RNF149

2

3

High-throughput

0.611

High

873935

LEG9C
Galectin-9C

3

20

High-throughput

0.609

High

205222

TGON2
Trans-Golgi network integral membrane protein 2

2

3

High-throughput

0.584

High

506945

LAMP1
Lysosome-associated membrane glycoprotein 1

2

5

High-throughput

0.584

High

873900

ARF6
ADP-ribosylation factor 6

2

5

High-throughput

0.584

High

873902

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

873890

S12A2
Solute carrier family 12 member 2

1

14

Small-scale

0.575

High

369252

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

873893

SC61B
Protein transport protein Sec61 subunit beta

2

0

High-throughput

0.559

High

62204

ARRD5
Arrestin domain-containing protein 5

1

2

High-throughput

0.536

High

156809

FFAR1
Free fatty acid receptor 1

1

10

High-throughput

0.536

High

234010

O10H2
Olfactory receptor 10H2

1

11

High-throughput

0.536

High

516012

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

2

High-throughput

0.536

High

723286

APJ
Apelin receptor

1

4

High-throughput

0.536

High

833186

TMEDA
Transmembrane emp24 domain-containing protein 10

1

4

High-throughput

0.536

High

873906

DLK1
Protein delta homolog 1

1

1

High-throughput

0.536

High

873915

ILK
Integrin-linked protein kinase

1

1

High-throughput

0.536

High

873917

KCNC3
Potassium voltage-gated channel subfamily C member 3

1

1

High-throughput

0.536

High

873932

TTMP
TPA-induced transmembrane protein

1

4

High-throughput

0.536

High

873948

M4A15
Membrane-spanning 4-domains subfamily A member 15

1

4

High-throughput

0.536

High

873951

SIDT2
SID1 transmembrane family member 2

1

2

High-throughput

0.536

High

873954

ARRD4
Arrestin domain-containing protein 4

1

2

High-throughput

0.536

High

873955

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

4

High-throughput

0.536

High

873966

ARRD3
Arrestin domain-containing protein 3

1

2

High-throughput

0.536

High

873978

TTYH1
Protein tweety homolog 1

1

4

High-throughput

0.536

High

873984

GPR35
G-protein coupled receptor 35

1

6

High-throughput

0.536

High

874000

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

2

High-throughput

0.536

High

340799

KAD1
Adenylate kinase isoenzyme 1

1

0

High-throughput

0.513

High

673555

MPIP3
M-phase inducer phosphatase 3

1

0

High-throughput

0.513

High

873908

EFNB1
Ephrin-B1

1

0

High-throughput

0.513

High

873923

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.513

High

873929

SHSL1
Protein shisa-like-1

1

0

High-throughput

0.513

High

873944

CNGA4
Cyclic nucleotide-gated channel alpha-4

1

0

High-throughput

0.513

High

873964

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

161049

CLGN
Calmegin

1

5

High-throughput

0.489

High

656359

DMB
HLA class II histocompatibility antigen, DM beta chain

1

1

High-throughput

0.489

High

873918

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

3

High-throughput

0.489

High

873928

LEG9B
Galectin-9B

1

20

High-throughput

0.489

High

873959

TMED6
Transmembrane emp24 domain-containing protein 6

1

6

High-throughput

0.489

High

873967

ZDH12
Palmitoyltransferase ZDHHC12

1

4

High-throughput

0.489

High

873994

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

1

8

Small-scale

0.481

High

120365

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

163781

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

2

High-throughput

0.479

High

169422

BET1
BET1 homolog

1

5

High-throughput

0.479

High

171206

CTDSL
CTD small phosphatase-like protein

1

1

High-throughput

0.479

High

178455

STX7
Syntaxin-7

1

6

High-throughput

0.479

High

212780

STX6
Syntaxin-6

1

5

High-throughput

0.479

High

226975

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

279489

FLOT1
Flotillin-1

1

1

High-throughput

0.479

High

305400

ZFPL1
Zinc finger protein-like 1

1

1

High-throughput

0.479

High

318090

DIRA3
GTP-binding protein Di-Ras3

1

6

High-throughput

0.479

High

320510

OXSR1
Serine/threonine-protein kinase OSR1

1

9

Small-scale

0.479

High

338185

EGFR
Epidermal growth factor receptor

1

4

High-throughput

0.479

High

384562

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

390144

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.479

High

411654

LCK
Tyrosine-protein kinase Lck

1

5

High-throughput

0.479

High

433663

LYN
Tyrosine-protein kinase Lyn

1

5

High-throughput

0.479

High

436225

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

496645

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.479

High

514677

CP2C9
Cytochrome P450 2C9

1

1

High-throughput

0.479

High

521828

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

527370

LAMP2
Lysosome-associated membrane glycoprotein 2

1

5

High-throughput

0.479

High

545288

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

564463

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

566986

CXA1
Gap junction alpha-1 protein

1

5

High-throughput

0.479

High

591534

RAB3B
Ras-related protein Rab-3B

1

5

High-throughput

0.479

High

591788

RAB4A
Ras-related protein Rab-4A

1

12

High-throughput

0.479

High

592178

RAB5A
Ras-related protein Rab-5A

1

15

High-throughput

0.479

High

594726

ATP4A
Potassium-transporting ATPase alpha chain 1

1

2

Small-scale

0.479

High

669946

MARCS
Myristoylated alanine-rich C-kinase substrate

1

1

High-throughput

0.479

High

719690

RADI
Radixin

1

1

High-throughput

0.479

High

793243

MUC18
Cell surface glycoprotein MUC18

1

1

High-throughput

0.479

High

844455

RAB5C
Ras-related protein Rab-5C

1

15

High-throughput

0.479

High

844839

RAB7A
Ras-related protein Rab-7a

1

14

High-throughput

0.479

High

845421

RAB9A
Ras-related protein Rab-9A

1

12

High-throughput

0.479

High

847416

BAP31
B-cell receptor-associated protein 31

1

3

High-throughput

0.479

High

852415

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

872625

EPHA4
Ephrin type-A receptor 4

1

3

High-throughput

0.479

High

873891

AFAD
Afadin

1

2

High-throughput

0.479

High

873892

ARL4C
ADP-ribosylation factor-like protein 4C

1

10

High-throughput

0.479

High

873894

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

Small-scale

0.479

High

873895

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

873896

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

873897

RAB2A
Ras-related protein Rab-2A

1

12

High-throughput

0.479

High

873898

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

873899

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

873901

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.479

High

873903

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

873907

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

873910

CAV1
Caveolin-1

1

2

High-throughput

0.479

High

873912

CKAP4
Cytoskeleton-associated protein 4

1

2

High-throughput

0.479

High

873914

STX4
Syntaxin-4

1

7

High-throughput

0.479

High

873920

RAB35
Ras-related protein Rab-35

1

6

High-throughput

0.479

High

873922

EPHA7
Ephrin type-A receptor 7

1

2

High-throughput

0.479

High

873924

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

873925

EREP1
Endosomal transmembrane epsin interactor 1

1

4

High-throughput

0.479

High

873927

OCLN
Occludin

1

1

High-throughput

0.479

High

873930

ZACN
Ligand-gated cation channel ZACN

1

5

High-throughput

0.479

High

873934

RNF43
E3 ubiquitin-protein ligase RNF43

1

3

High-throughput

0.479

High

873936

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.479

High

873938

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

873941

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

873946

CXD3
Gap junction delta-3 protein

1

5

High-throughput

0.479

High

873947

ARL14
ADP-ribosylation factor-like protein 14

1

6

High-throughput

0.479

High

873950

CGAS
Cyclic GMP-AMP synthase

1

3

Small-scale

0.479

High

873956

MCLN3
Mucolipin-3

1

1

High-throughput

0.479

High

873957

PARD3
Partitioning defective 3 homolog

1

1

High-throughput

0.479

High

873960

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

873962

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

High-throughput

0.479

High

873963

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.479

High

873968

DNJC1
DnaJ homolog subfamily C member 1

1

6

High-throughput

0.479

High

873969

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.479

High

873971

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

1

High-throughput

0.479

High

873973

DERL1
Derlin-1

1

1

High-throughput

0.479

High

873979

DNJC5
DnaJ homolog subfamily C member 5

1

1

High-throughput

0.479

High

873980

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

873983

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

873986

PXMP2
Peroxisomal membrane protein 2

1

1

High-throughput

0.479

High

873990

ELOV5
Very long chain fatty acid elongase 5

1

10

High-throughput

0.479

High

873991

TM216
Transmembrane protein 216

1

1

High-throughput

0.479

High

873995

DNJ5B
DnaJ homolog subfamily C member 5B

1

2

High-throughput

0.479

High

873996

SEC63
Translocation protein SEC63 homolog

1

2

High-throughput

0.479

High

873997

LAMP3
Lysosome-associated membrane glycoprotein 3

1

5

High-throughput

0.479

High

200376

HS12A
Heat shock 70 kDa protein 12A

1

0

High-throughput

0.458

High

390799

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

568600

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

0

High-throughput

0.458

High

573630

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

795084

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

825366

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

838739

EMD
Emerin

1

0

High-throughput

0.458

High

873904

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.458

High

873911

1433F
14-3-3 protein eta

1

0

High-throughput

0.458

High

873965

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

873970

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

873972

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

873974

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

873975

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

873981

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

873982

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

873987

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.458

High

873992

ANFY1
Rabankyrin-5

1

0

High-throughput

0.458

High

873993

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

209223

PSCA
Prostate stem cell antigen

1

1

High-throughput

0.445

High

602237

CD9
CD9 antigen

1

2

High-throughput

0.445

High

873998

ITM2B
Integral membrane protein 2B

1

3

High-throughput

0.445

High

776087

ARL1
ADP-ribosylation factor-like protein 1

1

6

High-throughput

0.437

High

873909

REEP5
Receptor expression-enhancing protein 5

1

1

High-throughput

0.437

High

873921

KS6A2
Ribosomal protein S6 kinase alpha-2

1

1

High-throughput

0.437

High

873926

MK14
Mitogen-activated protein kinase 14

1

1

Small-scale

0.437

High

873939

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

873942

TMM17
Transmembrane protein 17

1

3

High-throughput

0.437

High

873961

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

873976

DJC25
DnaJ homolog subfamily C member 25

1

3

High-throughput

0.437

High

873985

E41LA
Band 4.1-like protein 4A

1

1

High-throughput

0.437

High

873988

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.437

High

873999

DJC16
DnaJ homolog subfamily C member 16

1

5

High-throughput

0.437

High

873933

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

873913

SRSF1
Serine/arginine-rich splicing factor 1

1

0

High-throughput

0.279

Low

873945

TM192
Transmembrane protein 192

1

0

High-throughput

0.279

Low

873989

CARF
CDKN2A-interacting protein

1

0

High-throughput

0.279

Low

873949

COMD1
COMM domain-containing protein 1

1

0

Small-scale

0.275

Low

613391

SFPQ
Splicing factor, proline- and glutamine-rich

1

0

High-throughput

0.269

Low

132441

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

255620

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

296703

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.249

Low

329540

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

486494

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.249

Low

873905

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

873916

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.249

Low

873919

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

873931

MIDN
Midnolin

1

0

High-throughput

0.249

Low

873937

TECT3
Tectonic-3

1

0

High-throughput

0.249

Low

873940

MOB2
MOB kinase activator 2

1

0

High-throughput

0.249

Low

873943

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.249

Low

873952

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.249

Low

873958

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.249

Low

873977

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024