HitPredict

Interactor 1: MCM3 (P25205)
DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)
Gene: MCM3

Interactor 2: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	37827155, 21504906
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0003697 - single-stranded DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 808 Hs			1 616
+	Hs
		650666 MCM2_HUMAN (10-721): 0: 707: 30.62		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		651202 MCM6_HUMAN (2-800): 0: 688: 26.50		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		650488 MCM5_HUMAN (9-713): 0: 685: 28.92		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		650487 MCM4_HUMAN (9-739): 0: 661: 28.03		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		650489 MCM7_HUMAN (10-669): 0: 650: 31.62		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Sc
		607222 MCM2_YEAST (6-668): 0: 664: 32.15		RFA1_YEAST (4-615): 0: 596: 31.69
+	Sc
		607203 MCM3_YEAST (45-782): 0: 655: 44.49		RFA1_YEAST (4-615): 0: 596: 31.69
+	Sc
		607261 MCM7_YEAST (20-674): 8.95e-91: 305: 34.27		RFA1_YEAST (4-615): 0: 596: 31.69
+	Sc
		607223 MCM5_YEAST (8-650): 1.72e-86: 292: 31.51		RFA1_YEAST (4-615): 0: 596: 31.69