HitPredict

Interactor 1: MCM3 (P25205)
DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)
Gene: MCM3

Interactor 2: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.981

The method score is based on:

Property Details
Experiments 25963833, 17296731, 12614612, 35235311, 28514442, 23993743, 27621311, 30108253, 33961781, 15232106, 26167883, unassigned1913, 22540012
Identification Methods affinity chromatography technology, two hybrid, cross-linking study, pull down, anti tag coimmunoprecipitation, split luciferase complementation, protein array, tandem affinity purification, cosedimentation through density gradient
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains MCM~MCM, MCM~MCM_lid, MCM~MCM_N, MCM~MCM_OB, MCM_N~MCM_N, MCM_N~MCM_OB, MCM_OB~MCM_OB
Common GO terms GO:0000727 - double-strand break repair via break-induced replication
GO:0000781 - chromosome, telomeric region
GO:0003677 - DNA binding
GO:0003697 - single-stranded DNA binding
GO:0005524 - ATP binding
and 10 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 808
Hs

1 904
+ Mm
+ Xl
+ Dm
+ Hs
+ Xl
+ Hs
+ Hs
+ Mm
+ Hs
+ Dm
+ Hs
+ Hs
+ Xl
+ Mm
+ Sp
+ Dm
+ Xl
+ Xl
+ Xl
+ Sp

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Last updated: 15 Jul 2024