HitPredict

Interactor 1: MCM3 (P25205)
DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)
Gene: MCM3

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 808 Hs			1 126
+	Hs
		832512 MCM2_HUMAN (10-721): 0: 707: 30.62		H2B2F_HUMAN (1-126): 2.34e-54: 168: 97.62
+	Hs
		617935 MCM2_HUMAN (10-721): 0: 707: 30.62		H2B1O_HUMAN (1-126): 3.25e-54: 167: 99.21
+	Hs
		420814 MCM2_HUMAN (10-721): 0: 707: 30.62		H2B1J_HUMAN (1-126): 7.8e-54: 166: 99.21
+	Hs
		832322 MCM2_HUMAN (10-721): 0: 707: 30.62		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		832497 MCM2_HUMAN (10-721): 0: 707: 30.62		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		832624 MCM2_HUMAN (10-721): 0: 707: 30.62		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		832673 MCM2_HUMAN (10-721): 0: 707: 30.62		H2B1M_HUMAN (1-126): 5.38e-54: 166: 96.03
+	Hs
		241476 MCM2_HUMAN (10-721): 0: 707: 30.62		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		707553 MCM2_HUMAN (10-721): 0: 707: 30.62		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		832280 MCM2_HUMAN (10-721): 0: 707: 30.62		H2B1D_HUMAN (1-126): 3.5e-53: 164: 98.41
+	Hs
		832671 MCM2_HUMAN (10-721): 0: 707: 30.62		H2B1N_HUMAN (1-126): 3.35e-53: 164: 98.41
+	Hs
		832674 MCM2_HUMAN (10-721): 0: 707: 30.62		H2B1L_HUMAN (1-126): 2.49e-52: 162: 97.62
+	Hs
		832577 MCM2_HUMAN (10-721): 0: 707: 30.62		H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03
+	Hs
		1055566 MCM6_HUMAN (2-800): 0: 688: 26.50		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		1055603 MCM6_HUMAN (2-800): 0: 688: 26.50		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		832629 MCM2_HUMAN (10-721): 0: 707: 30.62		H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04
+	Hs
		241525 MCM6_HUMAN (2-800): 0: 688: 26.50		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		707629 MCM6_HUMAN (2-800): 0: 688: 26.50		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		241461 MCM5_HUMAN (9-713): 0: 685: 28.92		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		1055605 MCM6_HUMAN (2-800): 0: 688: 26.50		H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04