HitPredict

Interactor 1: MSGN1 (A6NI15)
Mesogenin-1 (Paraxial mesoderm-specific mesogenin1) (pMesogenin1) (pMsgn1)
Gene: MSGN1

Interactor 2: ID3 (Q02535)
DNA-binding protein inhibitor ID-3 (Class B basic helix-loop-helix protein 25) (bHLHb25) (Helix-loop-helix protein HEIR-1) (ID-like protein inhibitor HLH 1R21) (Inhibitor of DNA binding 3) (Inhibitor of differentiation 3)
Gene: ID3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0005634 - nucleus GO:0030154 - cell differentiation GO:0046983 - protein dimerization activity
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 193 Hs			1 119
+	Hs
		63044 MSGN1_HUMAN (1-193): 6.65e-72: 217: 100.00		ID2_HUMAN (1-118): 8.98e-43: 138: 39.13
+	Hs
		63039 MSGN1_HUMAN (1-193): 6.65e-72: 217: 100.00		ID1_HUMAN (1-100): 6.35e-42: 137: 47.22
+	Hs
		63041 MSGN1_HUMAN (1-193): 6.65e-72: 217: 100.00		ID4_HUMAN (1-88): 8.56e-27: 98.6: 40.71
+	Hs
		526744 MYF5_HUMAN (47-185): 5.58e-27: 104: 21.13		ID3_HUMAN (1-119): 1.28e-63: 190: 100.00
+	Mm
		485938 MYOD1_MOUSE (43-193): 1.73e-27: 107: 18.41		ID3_MOUSE (1-119): 9.94e-62: 186: 96.64
+	Hs
		545959 MYOD1_HUMAN (42-186): 4.8e-25: 100: 18.47		ID3_HUMAN (1-119): 1.28e-63: 190: 100.00
+	Hs
		970566 OLIG2_HUMAN (49-187): 6.03e-31: 116: 23.74		ID2_HUMAN (1-118): 8.98e-43: 138: 39.13
+	Mm
		781010 OLIG2_MOUSE (53-187): 5.78e-31: 116: 25.19		ID2_MOUSE (1-118): 2.33e-42: 137: 38.41
+	Mm
		485939 MYOD1_MOUSE (43-193): 1.73e-27: 107: 18.41		ID2_MOUSE (1-118): 2.33e-42: 137: 38.41
+	Hs
		526743 MYF5_HUMAN (47-185): 5.58e-27: 104: 21.13		ID2_HUMAN (1-118): 8.98e-43: 138: 39.13
+	Mm
		485951 MYOD1_MOUSE (43-193): 1.73e-27: 107: 18.41		Q6GTZ3_MOUSE (3-100): 6.94e-41: 134: 46.60
+	Hs
		526742 MYF5_HUMAN (47-185): 5.58e-27: 104: 21.13		ID1_HUMAN (1-100): 6.35e-42: 137: 47.22
+	Hs
		545958 MYOD1_HUMAN (42-186): 4.8e-25: 100: 18.47		ID2_HUMAN (1-118): 8.98e-43: 138: 39.13
+	Hs
		545945 MYOD1_HUMAN (42-186): 4.8e-25: 100: 18.47		ID1_HUMAN (1-100): 6.35e-42: 137: 47.22
+	Hs
		238590 MUSC_HUMAN (111-190): 7.81e-21: 87.2: 31.25		ID2_HUMAN (1-118): 8.98e-43: 138: 39.13
+	Mm
		781013 OLIG2_MOUSE (53-187): 5.78e-31: 116: 25.19		ID4_MOUSE (1-88): 1.17e-26: 98.6: 40.71
+	Hs
		814906 OLIG2_HUMAN (49-187): 6.03e-31: 116: 23.74		ID4_HUMAN (1-88): 8.56e-27: 98.6: 40.71
+	Hs
		616610 MYF6_HUMAN (35-191): 1.09e-30: 113: 23.57		ID4_HUMAN (1-88): 8.56e-27: 98.6: 40.71
+	Hs
		814916 NGN3_HUMAN (47-188): 4.67e-25: 98.7: 23.81		ID4_HUMAN (1-88): 8.56e-27: 98.6: 40.71