Protein: HEM1
5-aminolevulinate synthase, non-specific, mitochondrial (ALAS-H) (EC 2.3.1.37) (5-aminolevulinic acid synthase 1) (Delta-ALA synthase 1) (Delta-aminolevulinate synthase 1)

Gene: HEM1, ALAS1
Organism: Homo sapiens
Interactions: 137
UniProt ID: P13196

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0003870 - 5-aminolevulinate synthase activity
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

560826

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

3

15

High-throughput

0.861

High

560892

DUS19
Dual specificity protein phosphatase 19

7

3

High-throughput

0.686

High

560865

LONF1
LON peptidase N-terminal domain and RING finger protein 1

3

3

High-throughput

0.675

High

560903

EP400
E1A-binding protein p400

3

2

High-throughput

0.674

High

560908

TR61B
tRNA

3

1

High-throughput

0.667

High

560830

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

3

1

High-throughput

0.656

High

560878

CDC73
Parafibromin

3

0

High-throughput

0.654

High

248663

PEPL
Periplakin

3

0

High-throughput

0.646

High

560934

ZN175
Zinc finger protein 175

3

0

High-throughput

0.646

High

560932

PDIP2
Polymerase delta-interacting protein 2

2

1

High-throughput

0.640

High

560847

TYB10
Thymosin beta-10

4

2

High-throughput

0.639

High

560869

OXLD1
Oxidoreductase-like domain-containing protein 1

3

0

High-throughput

0.638

High

278618

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

2

1

High-throughput

0.628

High

560886

FABD
Malonyl-CoA-acyl carrier protein transacylase, mitochondrial

2

1

High-throughput

0.628

High

560924

TMOD3
Tropomodulin-3

2

2

High-throughput

0.628

High

560909

HINT2
Adenosine 5'-monophosphoramidase HINT2

2

3

High-throughput

0.611

High

560900

LRC45
Leucine-rich repeat-containing protein 45

2

2

High-throughput

0.606

High

560827

FPPS
Farnesyl pyrophosphate synthase

2

0

High-throughput

0.602

High

560863

PCKGM
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

2

0

High-throughput

0.602

High

560873

THEM4
Acyl-coenzyme A thioesterase THEM4

2

0

High-throughput

0.602

High

560904

ZN363
RING finger and CHY zinc finger domain-containing protein 1

2

0

High-throughput

0.602

High

279635

CISY
Citrate synthase, mitochondrial

2

3

High-throughput

0.584

High

560862

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

2

Small-scale

0.584

High

91646

HSBPL
Heat shock factor-binding protein 1-like protein 1

2

0

High-throughput

0.580

High

471768

RU2B
U2 small nuclear ribonucleoprotein B''

2

0

High-throughput

0.580

High

560874

UT14C
U3 small nucleolar RNA-associated protein 14 homolog C

2

0

High-throughput

0.580

High

560888

RN168
E3 ubiquitin-protein ligase RNF168

2

0

High-throughput

0.580

High

560898

FBXL8
F-box/LRR-repeat protein 8

2

0

High-throughput

0.580

High

560926

TMOD4
Tropomodulin-4

2

2

High-throughput

0.574

High

219544

WIPF1
WAS/WASL-interacting protein family member 1

1

1

High-throughput

0.573

High

560916

SH24A
SH2 domain-containing protein 4A

1

2

High-throughput

0.573

High

560931

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

1

High-throughput

0.573

High

560887

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

3

High-throughput

0.571

High

560833

CAP2
Adenylyl cyclase-associated protein 2

2

1

High-throughput

0.553

High

560882

MTSS2
Protein MTSS 2

2

1

High-throughput

0.553

High

560920

KIF9
Kinesin-like protein KIF9

2

2

High-throughput

0.553

High

560861

TCEA2
Transcription elongation factor A protein 2

1

0

High-throughput

0.549

High

560867

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

0

High-throughput

0.549

High

560879

MTFR2
Mitochondrial fission regulator 2

1

0

High-throughput

0.549

High

560884

SNX20
Sorting nexin-20

1

0

High-throughput

0.549

High

560891

CCHCR
Coiled-coil alpha-helical rod protein 1

1

0

High-throughput

0.549

High

560922

GNL3L
Guanine nucleotide-binding protein-like 3-like protein

1

0

High-throughput

0.549

High

560923

CB042
Uncharacterized protein C2orf42

1

0

High-throughput

0.549

High

366464

UROK
Urokinase-type plasminogen activator

1

2

High-throughput

0.541

High

560842

FXR1
RNA-binding protein FXR1

1

1

High-throughput

0.541

High

407571

S100B
Protein S100-B

1

1

High-throughput

0.536

High

560885

ECHD2
Enoyl-CoA hydratase domain-containing protein 2, mitochondrial

1

3

High-throughput

0.536

High

560927

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

1

High-throughput

0.536

High

560876

ZFY26
Zinc finger FYVE domain-containing protein 26

1

1

High-throughput

0.523

High

560890

CERK1
Ceramide kinase

1

1

High-throughput

0.523

High

528412

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

High-throughput

0.513

High

560846

ACTG
Actin, cytoplasmic 2

1

0

High-throughput

0.513

High

560856

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

0

High-throughput

0.513

High

560880

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

560907

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

1

0

High-throughput

0.513

High

560843

RAP1B
Ras-related protein Rap-1b

1

2

High-throughput

0.508

High

560844

SUMO2
Small ubiquitin-related modifier 2

1

3

High-throughput

0.508

High

560849

CDK5
Cyclin-dependent kinase 5

1

1

High-throughput

0.508

High

560829

OXYR
Oxytocin receptor

1

2

High-throughput

0.494

High

159950

IDLC
Axonemal dynein light intermediate polypeptide 1

1

0

High-throughput

0.493

High

560838

MAGA9
Melanoma-associated antigen 9

1

2

High-throughput

0.489

High

340613

STABP
STAM-binding protein

1

0

High-throughput

0.486

High

352673

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

0

High-throughput

0.486

High

405387

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.486

High

560832

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.486

High

560836

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1

0

High-throughput

0.486

High

560845

TYB4
Thymosin beta-4

1

1

High-throughput

0.481

High

61413

VWA8
von Willebrand factor A domain-containing protein 8

1

2

High-throughput

0.479

High

240620

PRKN
E3 ubiquitin-protein ligase parkin

1

9

High-throughput

0.479

High

281871

MPPB
Mitochondrial-processing peptidase subunit beta

1

4

High-throughput

0.479

High

287231

RF1M
Peptide chain release factor 1, mitochondrial

1

5

High-throughput

0.479

High

350777

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

2

High-throughput

0.479

High

470832

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

2

High-throughput

0.479

High

519041

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

532325

CH60
60 kDa heat shock protein, mitochondrial

1

6

High-throughput

0.479

High

560831

LONM
Lon protease homolog, mitochondrial

1

6

High-throughput

0.479

High

560835

MDHM
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.479

High

560837

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

560839

EFTS
Elongation factor Ts, mitochondrial

1

1

High-throughput

0.479

High

560840

IF2M
Translation initiation factor IF-2, mitochondrial

1

3

High-throughput

0.479

High

560841

EFTU
Elongation factor Tu, mitochondrial

1

3

High-throughput

0.479

High

560848

TFAM
Transcription factor A, mitochondrial

1

3

High-throughput

0.479

High

560850

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

560851

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

High-throughput

0.479

High

560853

MPPA
Mitochondrial-processing peptidase subunit alpha

1

4

High-throughput

0.479

High

560854

GRSF1
G-rich sequence factor 1

1

2

High-throughput

0.479

High

560855

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

6

High-throughput

0.479

High

560857

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

4

High-throughput

0.479

High

560858

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.479

High

560859

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

560860

PDK1
[Pyruvate dehydrogenase

1

2

High-throughput

0.479

High

560868

AGK
Acylglycerol kinase, mitochondrial

1

1

Small-scale

0.479

High

560872

SYAM
Alanine--tRNA ligase, mitochondrial

1

3

High-throughput

0.479

High

560877

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

560883

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

6

High-throughput

0.479

High

560895

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

6

High-throughput

0.479

High

560896

FAKD4
FAST kinase domain-containing protein 4

1

6

High-throughput

0.479

High

560897

CHCH1
Small ribosomal subunit protein mS37

1

1

High-throughput

0.479

High

560899

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

2

High-throughput

0.479

High

560901

MTEF3
Transcription termination factor 3, mitochondrial

1

1

High-throughput

0.479

High

560902

RCC1L
RCC1-like G exchanging factor-like protein

1

1

High-throughput

0.479

High

560905

EFGM
Elongation factor G, mitochondrial

1

6

High-throughput

0.479

High

560906

TACO1
Translational activator of cytochrome c oxidase 1

1

1

High-throughput

0.479

High

560910

RT26
Small ribosomal subunit protein mS26

1

1

High-throughput

0.479

High

560911

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

3

High-throughput

0.479

High

560912

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

2

High-throughput

0.479

High

560913

IF3M
Translation initiation factor IF-3, mitochondrial

1

1

High-throughput

0.479

High

560914

MTRFR
Mitochondrial translation release factor in rescue

1

5

High-throughput

0.479

High

560915

MTG2
Mitochondrial ribosome-associated GTPase 2

1

2

High-throughput

0.479

High

560918

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

560919

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

1

High-throughput

0.479

High

560921

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

1

High-throughput

0.479

High

560925

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

6

High-throughput

0.479

High

560928

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

560929

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

5

High-throughput

0.479

High

560933

RM11
Large ribosomal subunit protein uL11m

1

1

High-throughput

0.479

High

2023

A0A0A0MR80
E1A binding protein p400

1

2

High-throughput

0.470

High

560852

Q0P5Q0
Thymosin beta-4

1

2

High-throughput

0.470

High

560866

Q4G0R1
PIBF1 protein

1

1

High-throughput

0.470

High

560930

ICAM5
Intercellular adhesion molecule 5

1

1

High-throughput

0.470

High

560834

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.458

High

72920

B1AK13
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

1

High-throughput

0.445

High

560828

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.445

High

560935

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

4

High-throughput

0.445

High

560894

PIBF1
Progesterone-induced-blocking factor 1

1

1

High-throughput

0.439

High

560864

RTL8B
Retrotransposon Gag-like protein 8B

3

0

High-throughput

0.352

High

560889

ZN564
Zinc finger protein 564

3

0

High-throughput

0.352

High

560893

TEKT4
Tektin-4

3

0

High-throughput

0.352

High

560881

KLH35
Kelch-like protein 35

2

0

High-throughput

0.329

High

71650

GRCR1
Glutaredoxin domain-containing cysteine-rich protein 1

2

0

High-throughput

0.316

High

271128

COBL
Protein cordon-bleu

2

0

High-throughput

0.316

High

560870

ZMAT1
Zinc finger matrin-type protein 1

2

0

High-throughput

0.304

High

560875

TTC23
Tetratricopeptide repeat protein 23

1

0

High-throughput

0.299

High

560871

CC038
Uncharacterized protein C3orf38

1

0

High-throughput

0.279

Low

286795

JERKY
Jerky protein homolog

1

0

High-throughput

0.268

Low

560917

CH033
UPF0488 protein C8orf33

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025