HitPredict

Interactor 1: BRD2 (P25440)
Bromodomain-containing protein 2 (O27.1.1)
Gene: BRD2

Interactor 2: PB1 (Q86U86)
Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D)
Gene: PBRM1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	31753913, 30554943
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Bromodomain~Bromodomain
Common GO terms	GO:0000785 - chromatin GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 801 Hs			1 1689
+	Hs
		1067030 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		PB1_HUMAN (1-1689): 0: 1223: 100.00
+	Hs
		631349 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		DNMT1_HUMAN (301-1361): 1.76e-75: 280: 12.20
+	Hs
		600081 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		TAF1_HUMAN (457-963): 1.08e-57: 223: 16.79
+	Hs
		631525 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		PHIP_HUMAN (480-1024): 4.44e-53: 207: 13.50
+	Hs
		631431 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		BRD3_HUMAN (358-959): 6.75e-48: 186: 12.76
+	Hs
		641223 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		DNMT1_HUMAN (301-1361): 1.76e-75: 280: 12.20
+	Hs
		631454 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		BRDT_HUMAN (12-211): 7.3e-22: 105: 17.76
+	Hs
		631345 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		BRD2_HUMAN (2-169): 7.14e-20: 98.6: 15.29
+	Hs
		600145 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		TAF1_HUMAN (457-963): 1.08e-57: 223: 16.79
+	Xl
		945500 BRD4B_XENLA (26-800): 3.38e-101: 343: 42.84		P79922_XENLA (585-1361): 7.33e-72: 268: 13.31
+	Hs
		1067068 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		PHIP_HUMAN (480-1024): 4.44e-53: 207: 13.50
+	Hs
		631380 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		SMCA4_HUMAN (764-881): 7.55e-11: 69.5: 23.58
+	Hs
		631379 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		SMCA2_HUMAN (794-881): 2.15e-09: 64.9: 26.09
+	Hs
		243928 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		TAF1_HUMAN (457-963): 1.08e-57: 223: 16.79
+	Hs
		846977 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		SMCA4_HUMAN (764-881): 7.55e-11: 69.5: 23.58
+	Hs
		846778 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		SMCA2_HUMAN (794-881): 2.15e-09: 64.9: 26.09
+	Hs
		243951 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		BRD2_HUMAN (2-169): 7.14e-20: 98.6: 15.29
+	Hs
		846993 BRDT_HUMAN (48-763): 4.45e-106: 349: 45.39		SMCA4_HUMAN (764-881): 7.55e-11: 69.5: 23.58