HitPredict

Interactor 1: BRD2 (P25440)
Bromodomain-containing protein 2 (O27.1.1)
Gene: BRD2

Interactor 2: BRD9 (Q9H8M2)
Bromodomain-containing protein 9 (Rhabdomyosarcoma antigen MU-RMS-40.8)
Gene: BRD9

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	31753913, 30554943
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Bromodomain~Bromodomain
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0070577 - lysine-acetylated histone binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 801 Hs			1 597
+	Hs
		631602 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		BRD7_HUMAN (20-579): 2.88e-110: 346: 33.33
+	Hs
		1067144 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		BRD9_HUMAN (1-597): 1.05e-144: 433: 100.00
+	Hs
		244951 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		BRD9_HUMAN (1-597): 1.05e-144: 433: 100.00
+	Hs
		600081 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		TAF1_HUMAN (6-422): 2.77e-47: 181: 13.09
+	Hs
		631525 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		PHIP_HUMAN (112-417): 5.8e-43: 167: 17.31
+	Hs
		631382 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		BRPF1_HUMAN (48-329): 4.71e-41: 162: 23.71
+	Hs
		631488 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		PB1_HUMAN (94-466): 8.39e-27: 118: 15.30
+	Hs
		1067017 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		ATAD2_HUMAN (22-526): 1.29e-53: 199: 14.26
+	Hs
		600145 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		TAF1_HUMAN (6-422): 2.77e-47: 181: 13.09
+	Hs
		1067068 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		PHIP_HUMAN (112-417): 5.8e-43: 167: 17.31
+	Hs
		243928 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		TAF1_HUMAN (6-422): 2.77e-47: 181: 13.09
+	Hs
		244730 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		CBP_HUMAN (36-330): 7.44e-46: 176: 17.57
+	Hs
		1067030 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		PB1_HUMAN (94-466): 8.39e-27: 118: 15.30
+	Hs
		244704 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		PHIP_HUMAN (112-417): 5.8e-43: 167: 17.31
+	Hs
		245081 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		BRPF3_HUMAN (49-312): 2.15e-41: 162: 22.73
+	Hs
		244619 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		PB1_HUMAN (94-466): 8.39e-27: 118: 15.30
+	Hs
		244919 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		BRD8_HUMAN (5-266): 3.6e-24: 110: 15.27
+	Hs
		244347 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		EP300_HUMAN (238-403): 2.5e-10: 65.8: 12.09
+	Hs
		164439 TRI66_HUMAN (2-527): 1.93e-51: 197: 16.79		PHIP_HUMAN (112-417): 5.8e-43: 167: 17.31
+	Mm
		70879 EP300_MOUSE (202-448): 1.26e-40: 164: 24.71		F8VPR5_MOUSE (235-399): 2.83e-09: 62.4: 10.30