Protein: MED14
Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150)

Gene: MED14
Organism: Homo sapiens
Interactions: 134
UniProt ID: O60244

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

225356

CDK8
Cyclin-dependent kinase 8

16

18

Small-scale

0.986

High

48591

MED19
Mediator of RNA polymerase II transcription subunit 19

8

1

Small-scale

0.970

High

225416

CDK19
Cyclin-dependent kinase 19

7

18

High-throughput

0.966

High

225414

MED10
Mediator of RNA polymerase II transcription subunit 10

7

4

Small-scale

0.962

High

206594

MED7
Mediator of RNA polymerase II transcription subunit 7

6

5

Small-scale

0.950

High

225374

MED21
Mediator of RNA polymerase II transcription subunit 21

5

2

Small-scale

0.930

High

225422

MED4
Mediator of RNA polymerase II transcription subunit 4

4

2

High-throughput

0.906

High

225423

MED17
Mediator of RNA polymerase II transcription subunit 17

4

3

Small-scale

0.895

High

225438

MED31
Mediator of RNA polymerase II transcription subunit 31

2

4

High-throughput

0.811

High

225382

MED1
Mediator of RNA polymerase II transcription subunit 1

8

10

Small-scale

0.751

High

225404

MED12
Mediator of RNA polymerase II transcription subunit 12

7

18

Small-scale

0.746

High

225415

MED18
Mediator of RNA polymerase II transcription subunit 18

5

2

High-throughput

0.722

High

225435

MED23
Mediator of RNA polymerase II transcription subunit 23

5

3

Small-scale

0.720

High

225323

MED26
Mediator of RNA polymerase II transcription subunit 26

5

2

Small-scale

0.718

High

225318

MED24
Mediator of RNA polymerase II transcription subunit 24

5

1

Small-scale

0.714

High

225346

CCNC
Cyclin-C

5

12

High-throughput

0.714

High

225418

MED28
Mediator of RNA polymerase II transcription subunit 28

5

1

High-throughput

0.714

High

225424

MED9
Mediator of RNA polymerase II transcription subunit 9

5

1

Small-scale

0.712

High

225421

MED20
Mediator of RNA polymerase II transcription subunit 20

4

3

High-throughput

0.699

High

225426

MED29
Mediator of RNA polymerase II transcription subunit 29

4

2

High-throughput

0.699

High

225328

ESR1
Estrogen receptor

4

20

Small-scale

0.692

High

225358

NEK4
Serine/threonine-protein kinase Nek4

1

6

High-throughput

0.691

High

225410

MED15
Mediator of RNA polymerase II transcription subunit 15

4

12

Small-scale

0.686

High

225394

MED25
Mediator of RNA polymerase II transcription subunit 25

4

5

Small-scale

0.683

High

225317

BRD4
Bromodomain-containing protein 4

4

14

Small-scale

0.676

High

225340

VDR
Vitamin D3 receptor

3

20

Small-scale

0.667

High

225365

RPB7
DNA-directed RNA polymerase II subunit RPB7

3

5

High-throughput

0.667

High

225378

NR1I3
Nuclear receptor subfamily 1 group I member 3

3

20

High-throughput

0.667

High

225381

MED22
Mediator of RNA polymerase II transcription subunit 22

3

1

High-throughput

0.667

High

225433

MED13
Mediator of RNA polymerase II transcription subunit 13

3

4

High-throughput

0.662

High

225389

MED27
Mediator of RNA polymerase II transcription subunit 27

3

2

Small-scale

0.656

High

225437

MED16
Mediator of RNA polymerase II transcription subunit 16

3

1

Small-scale

0.656

High

225320

MED6
Mediator of RNA polymerase II transcription subunit 6

3

5

Small-scale

0.650

High

225393

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

3

4

High-throughput

0.650

High

225352

SRBP1
Sterol regulatory element-binding protein 1

3

14

Small-scale

0.641

High

225402

ESR2
Estrogen receptor beta

3

20

Small-scale

0.641

High

177631

BIRC5
Baculoviral IAP repeat-containing protein 5

2

3

High-throughput

0.628

High

181365

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

4

High-throughput

0.628

High

225345

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

4

High-throughput

0.628

High

225348

RBTN2
Rhombotin-2

2

7

High-throughput

0.628

High

225408

MED30
Mediator of RNA polymerase II transcription subunit 30

2

2

High-throughput

0.628

High

225440

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

2

3

Small-scale

0.619

High

225344

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

5

High-throughput

0.611

High

225347

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

7

High-throughput

0.611

High

225349

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

9

High-throughput

0.611

High

225360

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

2

3

High-throughput

0.611

High

225363

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

2

3

High-throughput

0.611

High

225397

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

2

20

High-throughput

0.611

High

225407

MED8
Mediator of RNA polymerase II transcription subunit 8

2

2

High-throughput

0.611

High

225428

MED11
Mediator of RNA polymerase II transcription subunit 11

2

2

High-throughput

0.611

High

225354

HNF4A
Hepatocyte nuclear factor 4-alpha

2

20

Small-scale

0.595

High

225405

FBXW7
F-box/WD repeat-containing protein 7

2

16

Small-scale

0.584

High

225361

STAT2
Signal transducer and activator of transcription 2

1

6

Small-scale

0.578

High

73022

B4DUB1
cDNA FLJ50029, highly similar to Cell division cycle 2-like protein kinase 6

1

17

High-throughput

0.575

High

225329

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.575

High

225335

PARP1
Poly [ADP-ribose] polymerase 1

1

15

Small-scale

0.561

High

225430

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

1

Small-scale

0.561

High

123791

SPT5H
Transcription elongation factor SPT5

1

9

High-throughput

0.536

High

131347

IMA4
Importin subunit alpha-4

1

3

High-throughput

0.536

High

225342

GATA1
Erythroid transcription factor

1

6

Small-scale

0.536

High

225362

KIF11
Kinesin-like protein KIF11

1

4

High-throughput

0.536

High

225369

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.536

High

225380

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.536

High

225384

HIF1A
Hypoxia-inducible factor 1-alpha

1

14

Small-scale

0.536

High

225388

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

8

High-throughput

0.536

High

225390

FXL19
F-box/LRR-repeat protein 19

1

7

High-throughput

0.536

High

225396

TAD2B
Transcriptional adapter 2-beta

1

5

High-throughput

0.536

High

225406

REPS1
RalBP1-associated Eps domain-containing protein 1

1

1

High-throughput

0.536

High

225436

HECD1
E3 ubiquitin-protein ligase HECTD1

2

17

High-throughput

0.533

High

225330

GCR
Glucocorticoid receptor

1

20

Small-scale

0.527

High

225375

LAMB3
Laminin subunit beta-3

1

1

High-throughput

0.489

High

225379

EMC2
ER membrane protein complex subunit 2

1

10

High-throughput

0.489

High

225401

ZCH10
Zinc finger CCHC domain-containing protein 10

1

1

High-throughput

0.489

High

225434

GPN3
GPN-loop GTPase 3

1

2

High-throughput

0.489

High

225341

ACTN1
Alpha-actinin-1

1

1

High-throughput

0.481

High

225350

ACTN2
Alpha-actinin-2

1

1

High-throughput

0.481

High

225377

DCTN1
Dynactin subunit 1

1

3

High-throughput

0.481

High

225417

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

6

High-throughput

0.481

High

61265

CNOT1
CCR4-NOT transcription complex subunit 1

1

2

Small-scale

0.479

High

225319

TAD2A
Transcriptional adapter 2-alpha

1

10

High-throughput

0.479

High

225321

UBR5
E3 ubiquitin-protein ligase UBR5

1

18

High-throughput

0.479

High

225322

SCAF4
SR-related and CTD-associated factor 4

1

14

High-throughput

0.479

High

225324

HERC2
E3 ubiquitin-protein ligase HERC2

1

14

High-throughput

0.479

High

225326

ABL1
Tyrosine-protein kinase ABL1

1

14

High-throughput

0.479

High

225332

ISG15
Ubiquitin-like protein ISG15

1

5

Small-scale

0.479

High

225333

FYN
Tyrosine-protein kinase Fyn

1

12

High-throughput

0.479

High

225338

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

225343

NCK1
SH2/SH3 adapter protein NCK1

1

13

High-throughput

0.479

High

225351

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

7

High-throughput

0.479

High

225353

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

Small-scale

0.479

High

225355

YAP1
Transcriptional coactivator YAP1

1

20

High-throughput

0.479

High

225359

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

4

High-throughput

0.479

High

225364

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

4

High-throughput

0.479

High

225366

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

3

High-throughput

0.479

High

225367

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.479

High

225368

H31
Histone H3.1

1

19

High-throughput

0.479

High

225370

HSF1
Heat shock factor protein 1

1

4

High-throughput

0.479

High

225371

IRF8
Interferon regulatory factor 8

1

9

Small-scale

0.479

High

225372

TP53B
TP53-binding protein 1

1

10

High-throughput

0.479

High

225373

TIF1B
Transcription intermediary factor 1-beta

1

16

High-throughput

0.479

High

225376

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

8

Small-scale

0.479

High

225383

SMAD1
Mothers against decapentaplegic homolog 1

1

6

Small-scale

0.479

High

225385

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

13

High-throughput

0.479

High

225386

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

14

High-throughput

0.479

High

225392

ACD11
Acyl-CoA dehydrogenase family member 11

1

1

High-throughput

0.479

High

225398

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

1

High-throughput

0.479

High

225399

SIR6
NAD-dependent protein deacylase sirtuin-6

1

9

High-throughput

0.479

High

225400

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

19

Small-scale

0.479

High

225409

QKI
KH domain-containing RNA-binding protein QKI

1

4

High-throughput

0.479

High

225412

T22D3
TSC22 domain family protein 3

1

1

Small-scale

0.479

High

225413

EPAS1
Endothelial PAS domain-containing protein 1

1

14

Small-scale

0.479

High

225420

STN1
CST complex subunit STN1

1

1

High-throughput

0.479

High

225427

TLS1
Splicing factor C9orf78

1

3

High-throughput

0.479

High

225431

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

11

Small-scale

0.479

High

225432

FXL17
F-box/LRR-repeat protein 17

1

0

Small-scale

0.460

High

91293

E5RFK5
Cyclin-C

1

12

High-throughput

0.445

High

225339

THA
Thyroid hormone receptor alpha

1

20

Small-scale

0.445

High

225403

KAT2A
Histone acetyltransferase KAT2A

1

20

Small-scale

0.445

High

225411

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.445

High

225439

TRRAP
Transformation/transcription domain-associated protein

1

4

Small-scale

0.445

High

225327

APOA2
Apolipoprotein A-II

1

1

High-throughput

0.437

High

225331

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.437

High

225334

IBP1
Insulin-like growth factor-binding protein 1

1

1

Small-scale

0.437

High

225336

IFIT2
Interferon-induced protein with tetratricopeptide repeats 2

1

9

Small-scale

0.437

High

225387

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

1

High-throughput

0.437

High

225391

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.437

High

225419

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.437

High

225429

HECW2
E3 ubiquitin-protein ligase HECW2

1

15

High-throughput

0.437

High

225357

CEBPA
CCAAT/enhancer-binding protein alpha

1

16

High-throughput

0.408

High

225337

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

2

High-throughput

0.407

High

225325

TCL1B
T-cell leukemia/lymphoma protein 1B

3

0

High-throughput

0.347

High

225395

NECA2
N-terminal EF-hand calcium-binding protein 2

1

0

High-throughput

0.251

Low

225425

ASND1
Asparagine synthetase domain-containing protein 1

1

0

High-throughput

0.249

Low

112036

ASURF
ASNSD1 upstream open reading frame protein

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024