HitPredict

Interactor 1: SPB1 (P25582)
27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase (EC 2.1.1.167) (2'-O-ribose RNA methyltransferase SPB1) (AdoMet-dependent rRNA methyltransferase SPB1) (S-adenosyl-L-methionine-dependent methyltransferase) (Suppressor of PAB1 protein 1)
Gene: SPB1

Interactor 2: SPB4 (P25808)
ATP-dependent rRNA helicase SPB4 (EC 3.6.4.13) (Suppressor of PAB1 protein 4)
Gene: SPB4

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.709

Property	Details
Experiments	36929751, 30568249, 37968396, 37811893, 21825077
Identification Methods	x-ray crystallography, affinity chromatography technology
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005730 - nucleolus GO:0030687 - preribosome, large subunit precursor
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 841 Sc			1 606
+	Sc
		634441 SPB1_YEAST (1-841): 0: 584: 100.00		HAS1_YEAST (6-467): 1.01e-156: 460: 30.98
+	Dm
		1363484 Q9VXK5_DROME (1-836): 2.02e-142: 442: 33.49		DDX18_DROME (6-481): 1.03e-152: 457: 28.96
+	Sc
		634387 SPB1_YEAST (1-841): 0: 584: 100.00		DRS1_YEAST (21-392): 3.9e-47: 178: 31.75
+	Hs
		1230913 CMTR1_HUMAN (4-348): 4.48e-87: 296: 14.07		DDX17_HUMAN (2-463): 7.88e-127: 391: 21.89
+	Hs
		571516 CMTR1_HUMAN (4-348): 4.48e-87: 296: 14.07		DDX5_HUMAN (2-454): 2.38e-125: 384: 22.34
+	Hs
		134119 CMTR1_HUMAN (4-348): 4.48e-87: 296: 14.07		DDX3X_HUMAN (4-406): 1.31e-116: 363: 24.40
+	Dm
		1367917 Q9VXK5_DROME (1-836): 2.02e-142: 442: 33.49		DDX47_DROME (3-376): 3.85e-54: 194: 33.87
+	Sc
		638888 MDN1_YEAST (303-790): 6.99e-32: 137: 9.25		SPB4_YEAST (1-606): 2.46e-149: 445: 100.00
+	Hs
		1154061 NIPBL_HUMAN (203-771): 1.12e-14: 80.8: 10.84		DDX17_HUMAN (2-463): 7.88e-127: 391: 21.89
+	Hs
		1154074 NIPBL_HUMAN (203-771): 1.12e-14: 80.8: 10.84		DDX47_HUMAN (23-382): 7.93e-54: 191: 34.35