HitPredict

Interactor 1: PSA1 (P25786)
Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain)
Gene: PSMA1

Interactor 2: PSME4 (Q14997)
Proteasome activator complex subunit 4 (Proteasome activator PA200)
Gene: PSME4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	26186194, 28514442, 33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BLM10_mid~Proteasome, DUF3437~Proteasome, BLM10_mid~Proteasome_A_N, DUF3437~Proteasome_A_N
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 263 Hs			1 1843
+	Hs
		156290 PSA7_HUMAN (6-234): 9.99e-96: 282: 33.19		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		656228 PSA5_HUMAN (1-236): 5.66e-93: 275: 28.81		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		893671 PSA6_HUMAN (1-240): 1.64e-92: 274: 25.00		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		638132 PSA4_HUMAN (1-233): 4.82e-91: 271: 28.75		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Sc
		771335 PSA6_YEAST (1-233): 3.26e-83: 250: 52.77		BLM10_YEAST (74-831): 0: 722: 16.61