Protein: ARPC4
Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC)

Gene: ARPC4
Organism: Homo sapiens
Interactions: 155
UniProt ID: P59998

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005200 - structural constituent of cytoskeleton
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0005885 - Arp2/3 protein complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

948463

ARP5L
Actin-related protein 2/3 complex subunit 5-like protein

18

5

Small-scale

0.986

High

192701

ARPC5
Actin-related protein 2/3 complex subunit 5

15

5

Small-scale

0.981

High

179174

ARC1B
Actin-related protein 2/3 complex subunit 1B

8

5

Small-scale

0.970

High

948482

ARP3B
Actin-related protein 3B

5

7

High-throughput

0.932

High

948409

ARP2
Actin-related protein 2

5

6

High-throughput

0.930

High

179327

ARPC2
Actin-related protein 2/3 complex subunit 2

5

3

Small-scale

0.928

High

948408

ARP3
Actin-related protein 3

4

7

Small-scale

0.900

High

948457

ARC1A
Actin-related protein 2/3 complex subunit 1A

4

5

Small-scale

0.900

High

179487

ARPC3
Actin-related protein 2/3 complex subunit 3

7

5

Small-scale

0.749

High

948406

ACTB
Actin, cytoplasmic 1

1

2

High-throughput

0.691

High

948461

PNMA5
Paraneoplastic antigen-like protein 5

4

0

High-throughput

0.668

High

948476

ANLN
Anillin

3

0

High-throughput

0.628

High

563505

CFTR
Cystic fibrosis transmembrane conductance regulator

3

0

High-throughput

0.622

High

948413

ACTC
Actin, alpha cardiac muscle 1

1

2

High-throughput

0.618

High

948474

ARP8
Actin-related protein 8

1

7

High-throughput

0.618

High

948425

SRC8
Src substrate cortactin

2

1

Small-scale

0.611

High

133651

WASL
Actin nucleation-promoting factor WASL

2

3

High-throughput

0.606

High

529453

TAU
Microtubule-associated protein tau

2

1

High-throughput

0.601

High

241239

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

948452

MT21A
Protein N-lysine methyltransferase METTL21A

2

0

High-throughput

0.580

High

635701

RASA1
Ras GTPase-activating protein 1

2

2

High-throughput

0.571

High

345584

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

0

High-throughput

0.559

High

371600

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.559

High

948465

ACE2
Angiotensin-converting enzyme 2

2

0

High-throughput

0.559

High

277906

SH3L1
Adapter SH3BGRL

2

0

High-throughput

0.547

High

637420

FLNA
Filamin-A

1

1

High-throughput

0.536

High

842629

WASP
Actin nucleation-promoting factor WAS

1

4

Small-scale

0.536

High

862767

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

1

High-throughput

0.536

High

866630

CAZA2
F-actin-capping protein subunit alpha-2

1

1

High-throughput

0.536

High

866946

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

948415

CALD1
Caldesmon

1

2

High-throughput

0.536

High

948460

MYO19
Unconventional myosin-XIX

1

2

High-throughput

0.536

High

948446

NELFD
Negative elongation factor C/D

1

0

High-throughput

0.518

High

948435

DNAI4
Dynein axonemal intermediate chain 4

1

0

High-throughput

0.517

High

224673

ACTN4
Alpha-actinin-4

1

0

High-throughput

0.513

High

389197

FINC
Fibronectin

1

0

High-throughput

0.513

High

470953

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.513

High

772702

MYH9
Myosin-9

1

0

High-throughput

0.513

High

920416

DAPK1
Death-associated protein kinase 1

1

0

High-throughput

0.513

High

948410

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

0

High-throughput

0.513

High

948417

TWF1
Twinfilin-1

1

0

High-throughput

0.513

High

948424

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.513

High

948430

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

948432

DREB
Drebrin

1

0

High-throughput

0.513

High

948447

SYNPO
Synaptopodin

1

0

High-throughput

0.513

High

948477

PDLI7
PDZ and LIM domain protein 7

1

0

High-throughput

0.513

High

948478

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.513

High

948483

STK26
Serine/threonine-protein kinase 26

1

0

High-throughput

0.513

High

352380

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.493

High

948455

MY18A
Unconventional myosin-XVIIIa

1

1

High-throughput

0.489

High

889384

CLK1
Dual specificity protein kinase CLK1

1

0

High-throughput

0.480

High

323260

TRI37
E3 ubiquitin-protein ligase TRIM37

1

1

High-throughput

0.479

High

330803

KI20A
Kinesin-like protein KIF20A

1

1

High-throughput

0.479

High

534850

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.479

High

897684

CDK9
Cyclin-dependent kinase 9

1

1

High-throughput

0.479

High

948422

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

948427

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

948434

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

Small-scale

0.479

High

948442

NUFP2
FMR1-interacting protein NUFIP2

1

1

High-throughput

0.479

High

948445

ZN547
Zinc finger protein 547

1

1

High-throughput

0.479

High

948453

ASB11
Ankyrin repeat and SOCS box protein 11

1

1

High-throughput

0.479

High

948462

RING2
E3 ubiquitin-protein ligase RING2

1

1

High-throughput

0.479

High

948464

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

948468

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

948479

RNF12
E3 ubiquitin-protein ligase RLIM

1

1

High-throughput

0.479

High

948486

DUX4
Double homeobox protein 4

1

1

High-throughput

0.479

High

948488

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.479

High

948491

TTLL3
Tubulin monoglycylase TTLL3

1

1

High-throughput

0.479

High

560346

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.470

High

135119

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

0

High-throughput

0.458

High

172632

XPO1
Exportin-1

1

0

High-throughput

0.458

High

178225

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.458

High

247778

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

315348

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

390510

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.458

High

400565

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

482387

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.458

High

536855

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

565264

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

588340

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

629695

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

646804

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

674982

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.458

High

695069

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

762433

PROF2
Profilin-2

1

0

High-throughput

0.458

High

767829

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

785031

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.458

High

785812

8ODP
Oxidized purine nucleoside triphosphate hydrolase

1

0

Small-scale

0.458

High

791232

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

830442

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

837496

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

838041

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

High-throughput

0.458

High

872127

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

887884

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

929861

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.458

High

947092

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.458

High

948407

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

High-throughput

0.458

High

948411

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

948416

FOXO1
Forkhead box protein O1

1

0

High-throughput

0.458

High

948418

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

948420

PPIG
Peptidyl-prolyl cis-trans isomerase G

1

0

High-throughput

0.458

High

948421

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

948423

CUL4B
Cullin-4B

1

0

Small-scale

0.458

High

948428

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

948429

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

948431

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

948436

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

948437

TUT7
Terminal uridylyltransferase 7

1

0

High-throughput

0.458

High

948438

TET2
Methylcytosine dioxygenase TET2

1

0

High-throughput

0.458

High

948443

MORC1
MORC family CW-type zinc finger protein 1

1

0

High-throughput

0.458

High

948448

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

948451

UB2Q2
Ubiquitin-conjugating enzyme E2 Q2

1

0

Small-scale

0.458

High

948456

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

948458

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

948466

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

0

High-throughput

0.458

High

948467

RHBT2
Rho-related BTB domain-containing protein 2

1

0

High-throughput

0.458

High

948470

SIK2
Serine/threonine-protein kinase SIK2

1

0

Small-scale

0.458

High

948471

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

948473

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

948475

SENP2
Sentrin-specific protease 2

1

0

Small-scale

0.458

High

948484

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.458

High

948485

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

0

High-throughput

0.458

High

948487

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

948492

NGN3
Neurogenin-3

1

0

Small-scale

0.458

High

516487

CALM3
Calmodulin-3

1

1

High-throughput

0.445

High

765298

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

902963

INSL3
Insulin-like 3

1

1

High-throughput

0.437

High

948414

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

948441

ASXL2
Putative Polycomb group protein ASXL2

1

1

High-throughput

0.437

High

948454

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

948469

ASXL3
Putative Polycomb group protein ASXL3

1

1

High-throughput

0.437

High

948472

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

429610

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

619650

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.426

High

934354

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.426

High

948412

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.426

High

948419

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.426

High

948489

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High

948444

GOLI
E3 ubiquitin-protein ligase RNF130

1

1

High-throughput

0.417

High

159962

IDLC
Axonemal dynein light intermediate polypeptide 1

1

0

High-throughput

0.279

Low

948449

CHUR
Protein Churchill

1

0

High-throughput

0.279

Low

948450

BCL7C
B-cell CLL/lymphoma 7 protein family member C

1

0

High-throughput

0.279

Low

948459

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.279

Low

948480

CARF
CDKN2A-interacting protein

1

0

High-throughput

0.279

Low

353164

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.269

Low

105665

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

254570

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.249

Low

878854

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

948426

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

948439

SOSD1
Sclerostin domain-containing protein 1

1

0

Small-scale

0.249

Low

948440

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

948481

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

948490

PHOCN
MOB-like protein phocein

1

0

High-throughput

0.249

Low

254913

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

948433

LETM2
LETM1 domain-containing protein LETM2, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025