HitPredict

Interactor 1: PSA2 (P25787)
Proteasome subunit alpha type-2 (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) (Proteasome component C3)
Gene: PSMA2

Interactor 2: UBP14 (P54578)
Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14)
Gene: USP14

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	30425250, 31901637, 19193609
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0070062 - extracellular exosome
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 234 Hs			1 494
+	Hs
		656182 PSA5_HUMAN (1-233): 2.69e-97: 285: 30.96		UBP14_HUMAN (1-494): 7.04e-147: 431: 100.00
+	Hs
		870721 PSA6_HUMAN (2-234): 2.68e-90: 267: 34.73		UBP14_HUMAN (1-494): 7.04e-147: 431: 100.00
+	Hs
		156259 PSA7_HUMAN (6-231): 1.49e-89: 266: 36.52		UBP14_HUMAN (1-494): 7.04e-147: 431: 100.00
+	Hs
		637368 PSA1_HUMAN (1-233): 1.31e-89: 266: 30.67		UBP14_HUMAN (1-494): 7.04e-147: 431: 100.00
+	Sp
		1265793 PSA5_SCHPO (1-232): 2.58e-98: 288: 32.64		UBP6_SCHPO (3-485): 1.47e-112: 342: 36.31
+	Hs
		638094 PSA4_HUMAN (4-211): 1.24e-42: 146: 38.68		UBP14_HUMAN (1-494): 7.04e-147: 431: 100.00
+	Sc
		619485 PSA2_YEAST (1-233): 4.51e-84: 252: 56.97		UBP6_YEAST (4-481): 1.15e-88: 282: 30.10
+	Sc
		771371 PSA4_YEAST (5-233): 3.86e-46: 155: 38.14		UBP6_YEAST (4-481): 1.15e-88: 282: 30.10
+	Sc
		619371 PSA3_YEAST (1-230): 8.97e-46: 154: 36.40		UBP6_YEAST (4-481): 1.15e-88: 282: 30.10