Protein: FLNB
Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)

Gene: FLNB
Organism: Homo sapiens
Interactions: 228
UniProt ID: O75369

Gene Ontology (top 5):
GO:0001725 - stress fiber
GO:0003334 - keratinocyte development
GO:0003382 - epithelial cell morphogenesis
GO:0003723 - RNA binding
GO:0003779 - actin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

278014

FLNA
Filamin-A

8

17

Small-scale

0.967

High

278084

FLNC
Filamin-C

3

18

High-throughput

0.827

High

278127

FBLI1
Filamin-binding LIM protein 1

2

20

Small-scale

0.821

High

278173

HSPB7
Heat shock protein beta-7

2

17

High-throughput

0.811

High

277977

FLNB
Filamin-B

2

16

Small-scale

0.743

High

277988

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

4

High-throughput

0.743

High

249072

DSCAM
Cell adhesion molecule DSCAM

1

14

High-throughput

0.698

High

277990

HSPB1
Heat shock protein beta-1

1

14

High-throughput

0.698

High

278085

MYPC2
Myosin-binding protein C, fast-type

1

20

High-throughput

0.698

High

277986

FINC
Fibronectin

1

20

High-throughput

0.691

High

278037

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

9

High-throughput

0.691

High

278093

MARE1
Microtubule-associated protein RP/EB family member 1

1

8

High-throughput

0.691

High

278176

LIMA1
LIM domain and actin-binding protein 1

1

17

High-throughput

0.691

High

277994

ITB1
Integrin beta-1

1

20

Small-scale

0.680

High

277993

ISG15
Ubiquitin-like protein ISG15

3

11

Small-scale

0.657

High

278166

ANLN
Anillin

3

10

High-throughput

0.656

High

278003

CFTR
Cystic fibrosis transmembrane conductance regulator

3

8

High-throughput

0.650

High

278022

ARRB2
Beta-arrestin-2

2

3

High-throughput

0.628

High

277992

ITB3
Integrin beta-3

1

20

Small-scale

0.621

High

278009

ITB6
Integrin beta-6

1

20

Small-scale

0.621

High

278050

ACTB
Actin, cytoplasmic 1

1

20

High-throughput

0.618

High

278057

ACTA
Actin, aortic smooth muscle

1

20

High-throughput

0.618

High

278060

ACTC
Actin, alpha cardiac muscle 1

1

20

High-throughput

0.618

High

278115

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.618

High

278175

TES
Testin

1

20

High-throughput

0.618

High

278071

G3BP1
Ras GTPase-activating protein-binding protein 1

2

3

High-throughput

0.611

High

278011

VCAM1
Vascular cell adhesion protein 1

2

19

High-throughput

0.601

High

278102

OTUD1
OTU domain-containing protein 1

3

11

Small-scale

0.599

High

278049

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

2

4

Small-scale

0.595

High

277984

MYC
Myc proto-oncogene protein

3

10

High-throughput

0.585

High

240275

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.584

High

277997

CALM3
Calmodulin-3

1

5

High-throughput

0.575

High

278076

TBB3
Tubulin beta-3 chain

1

3

High-throughput

0.575

High

278116

TBA1A
Tubulin alpha-1A chain

1

4

High-throughput

0.575

High

278041

PSN1
Presenilin-1

1

5

Small-scale

0.573

High

278042

PSN2
Presenilin-2

1

5

Small-scale

0.573

High

278058

GRB2
Growth factor receptor-bound protein 2

2

20

High-throughput

0.571

High

278044

FXR1
RNA-binding protein FXR1

1

9

High-throughput

0.541

High

139039

LAD1
Ladinin-1

1

13

High-throughput

0.536

High

278001

RALA
Ras-related protein Ral-A

1

9

High-throughput

0.536

High

278027

MYH9
Myosin-9

1

13

High-throughput

0.536

High

278038

CAZA2
F-actin-capping protein subunit alpha-2

1

8

High-throughput

0.536

High

278039

CAPZB
F-actin-capping protein subunit beta

1

5

High-throughput

0.536

High

278055

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

8

High-throughput

0.536

High

278059

RAC1
Ras-related C3 botulinum toxin substrate 1

1

11

Small-scale

0.536

High

278064

CALD1
Caldesmon

1

20

High-throughput

0.536

High

278070

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

15

Small-scale

0.536

High

278073

CENPR
Centromere protein R

1

1

High-throughput

0.536

High

278078

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

8

High-throughput

0.536

High

278082

SCRB2
Lysosome membrane protein 2

1

2

High-throughput

0.536

High

278083

SRC8
Src substrate cortactin

1

18

High-throughput

0.536

High

278096

DREB
Drebrin

1

13

High-throughput

0.536

High

278132

MY18A
Unconventional myosin-XVIIIa

1

19

High-throughput

0.536

High

278139

VMP1
Vacuole membrane protein 1

1

2

High-throughput

0.536

High

278140

MYO19
Unconventional myosin-XIX

1

15

High-throughput

0.536

High

278160

PHAX
Phosphorylated adapter RNA export protein

1

1

High-throughput

0.536

High

278177

NUDT5
ADP-sugar pyrophosphatase

1

2

High-throughput

0.536

High

277996

GP1BA
Platelet glycoprotein Ib alpha chain

1

6

Small-scale

0.527

High

278032

CCNF
Cyclin-F

1

6

High-throughput

0.515

High

278033

MK08
Mitogen-activated protein kinase 8

1

13

Small-scale

0.515

High

278150

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

278168

HAUS2
HAUS augmin-like complex subunit 2

1

0

High-throughput

0.513

High

278031

MLH1
DNA mismatch repair protein Mlh1

1

1

Small-scale

0.508

High

278098

PKHO1
Pleckstrin homology domain-containing family O member 1

1

1

High-throughput

0.508

High

278163

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

14

High-throughput

0.508

High

278053

SUMO2
Small ubiquitin-related modifier 2

1

10

High-throughput

0.501

High

278061

XIAP
E3 ubiquitin-protein ligase XIAP

1

8

High-throughput

0.501

High

278142

ASB2
Ankyrin repeat and SOCS box protein 2

1

12

Small-scale

0.501

High

277987

ESR1
Estrogen receptor

1

20

High-throughput

0.500

High

278183

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

7

Small-scale

0.500

High

278151

RTF2
Replication termination factor 2

1

1

High-throughput

0.489

High

278164

TANC2
Protein TANC2

1

17

High-throughput

0.489

High

238327

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.486

High

184254

NPHP1
Nephrocystin-1

1

2

Small-scale

0.481

High

278153

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.481

High

278169

RN216
E3 ubiquitin-protein ligase RNF216

1

1

Small-scale

0.481

High

58690

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

1

5

High-throughput

0.479

High

125105

LEG9
Galectin-9

1

6

High-throughput

0.479

High

136753

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

13

High-throughput

0.479

High

137881

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

5

High-throughput

0.479

High

156763

CTRO
Citron Rho-interacting kinase

1

16

High-throughput

0.479

High

222576

PRC1
Protein regulator of cytokinesis 1

1

15

High-throughput

0.479

High

247192

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

10

High-throughput

0.479

High

247560

NUPR1
Nuclear protein 1

1

5

High-throughput

0.479

High

271762

OBSL1
Obscurin-like protein 1

1

20

High-throughput

0.479

High

277979

TRI37
E3 ubiquitin-protein ligase TRIM37

1

15

High-throughput

0.479

High

277981

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

277982

FMNL1
Formin-like protein 1

1

2

Small-scale

0.479

High

277989

P53
Cellular tumor antigen p53

1

5

Small-scale

0.479

High

277991

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

4

High-throughput

0.479

High

277995

NPM
Nucleophosmin

1

2

High-throughput

0.479

High

277999

BIP
Endoplasmic reticulum chaperone BiP

1

13

High-throughput

0.479

High

278000

HSP7C
Heat shock cognate 71 kDa protein

1

6

High-throughput

0.479

High

278002

CADH1
Cadherin-1

1

6

High-throughput

0.479

High

278004

ITA4
Integrin alpha-4

1

3

High-throughput

0.479

High

278006

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.479

High

278008

CEBPB
CCAAT/enhancer-binding protein beta

1

9

High-throughput

0.479

High

278010

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

5

High-throughput

0.479

High

278012

BTF3
Transcription factor BTF3

1

5

High-throughput

0.479

High

278015

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

7

High-throughput

0.479

High

278017

GCSP
Glycine dehydrogenase

1

4

High-throughput

0.479

High

278018

CDK2
Cyclin-dependent kinase 2

1

6

High-throughput

0.479

High

278020

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

8

High-throughput

0.479

High

278021

STIP1
Stress-induced-phosphoprotein 1

1

5

High-throughput

0.479

High

278023

MCM5
DNA replication licensing factor MCM5

1

11

High-throughput

0.479

High

278024

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

2

High-throughput

0.479

High

278028

PGM1
Phosphoglucomutase-1

1

1

High-throughput

0.479

High

278029

SYUA
Alpha-synuclein

1

3

High-throughput

0.479

High

278030

BRCA1
Breast cancer type 1 susceptibility protein

1

12

High-throughput

0.479

High

278034

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

12

Small-scale

0.479

High

278035

CRK
Adapter molecule crk

1

20

High-throughput

0.479

High

278036

YAP1
Transcriptional coactivator YAP1

1

19

High-throughput

0.479

High

278040

MCM2
DNA replication licensing factor MCM2

1

11

High-throughput

0.479

High

278043

CDK9
Cyclin-dependent kinase 9

1

16

High-throughput

0.479

High

278045

HDGF
Hepatoma-derived growth factor

1

2

High-throughput

0.479

High

278046

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

11

High-throughput

0.479

High

278051

UBC12
NEDD8-conjugating enzyme Ubc12

1

2

High-throughput

0.479

High

278052

ABCE1
ATP-binding cassette sub-family E member 1

1

3

High-throughput

0.479

High

278056

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

278062

KIF23
Kinesin-like protein KIF23

1

14

High-throughput

0.479

High

278063

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

3

High-throughput

0.479

High

278065

AHNK
Neuroblast differentiation-associated protein AHNAK

1

11

High-throughput

0.479

High

278066

TFCP2
Alpha-globin transcription factor CP2

1

3

High-throughput

0.479

High

278067

ANK3
Ankyrin-3

1

11

High-throughput

0.479

High

278068

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

16

High-throughput

0.479

High

278069

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

1

Small-scale

0.479

High

278072

KCAB2
Voltage-gated potassium channel subunit beta-2

1

7

High-throughput

0.479

High

278075

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

278077

HDAC1
Histone deacetylase 1

1

11

High-throughput

0.479

High

278080

CUL3
Cullin-3

1

14

High-throughput

0.479

High

278086

MDC1
Mediator of DNA damage checkpoint protein 1

1

16

High-throughput

0.479

High

278087

CUL7
Cullin-7

1

7

High-throughput

0.479

High

278089

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

278090

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

278091

KIF14
Kinesin-like protein KIF14

1

10

High-throughput

0.479

High

278095

EZH2
Histone-lysine N-methyltransferase EZH2

1

7

High-throughput

0.479

High

278099

PRC2B
Protein PRRC2B

1

15

High-throughput

0.479

High

278103

OTU1
Ubiquitin thioesterase OTU1

1

1

High-throughput

0.479

High

278104

RN123
E3 ubiquitin-protein ligase RNF123

1

3

High-throughput

0.479

High

278107

VIR
Protein virilizer homolog

1

3

High-throughput

0.479

High

278108

CAPR2
Caprin-2

1

5

High-throughput

0.479

High

278109

CDC73
Parafibromin

1

6

High-throughput

0.479

High

278110

RICTR
Rapamycin-insensitive companion of mTOR

1

5

High-throughput

0.479

High

278114

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

20

High-throughput

0.479

High

278119

SLN11
Schlafen family member 11

1

1

High-throughput

0.479

High

278120

ZN598
E3 ubiquitin-protein ligase ZNF598

1

3

High-throughput

0.479

High

278122

SYNPO
Synaptopodin

1

17

High-throughput

0.479

High

278124

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

4

Small-scale

0.479

High

278125

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

278126

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

278128

NUDC2
NudC domain-containing protein 2

1

4

High-throughput

0.479

High

278129

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

1

High-throughput

0.479

High

278130

TOPB1
DNA topoisomerase 2-binding protein 1

1

14

High-throughput

0.479

High

278131

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

8

High-throughput

0.479

High

278137

CHM4C
Charged multivesicular body protein 4c

1

19

High-throughput

0.479

High

278138

SPDLY
Protein Spindly

1

16

High-throughput

0.479

High

278141

CNDP2
Cytosolic non-specific dipeptidase

1

1

High-throughput

0.479

High

278143

CK5P2
CDK5 regulatory subunit-associated protein 2

1

20

Small-scale

0.479

High

278144

RING2
E3 ubiquitin-protein ligase RING2

1

14

High-throughput

0.479

High

278146

ANM1
Protein arginine N-methyltransferase 1

1

4

High-throughput

0.479

High

278147

DUS23
Dual specificity protein phosphatase 23

1

8

High-throughput

0.479

High

278148

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

19

High-throughput

0.479

High

278149

FACD2
Fanconi anemia group D2 protein

1

9

High-throughput

0.479

High

278152

ACE2
Angiotensin-converting enzyme 2

1

6

High-throughput

0.479

High

278156

CCDC8
Coiled-coil domain-containing protein 8

1

3

High-throughput

0.479

High

278157

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

20

High-throughput

0.479

High

278158

CHM4B
Charged multivesicular body protein 4b

1

19

High-throughput

0.479

High

278159

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

278161

ECT2
Protein ECT2

1

18

High-throughput

0.479

High

278167

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

9

High-throughput

0.479

High

278170

PIHD1
PIH1 domain-containing protein 1

1

3

High-throughput

0.479

High

278171

PD1L1
Programmed cell death 1 ligand 1

1

8

Small-scale

0.479

High

278172

HDAC6
Protein deacetylase HDAC6

1

14

High-throughput

0.479

High

278174

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

278178

FZR1
Fizzy-related protein homolog

1

15

High-throughput

0.479

High

278179

UBQL1
Ubiquilin-1

1

4

High-throughput

0.479

High

278181

LOXL2
Lysyl oxidase homolog 2

1

7

High-throughput

0.479

High

278182

YTHD2
YTH domain-containing family protein 2

1

3

High-throughput

0.479

High

277983

AGR2
Anterior gradient protein 2 homolog

1

6

High-throughput

0.470

High

60697

F234B
Protein FAM234B

1

0

High-throughput

0.458

High

278081

C1D
Nuclear nucleic acid-binding protein C1D

1

0

High-throughput

0.458

High

278136

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

278165

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

277980

FA13A
Protein FAM13A

1

9

Small-scale

0.457

High

278113

MCAF1
Activating transcription factor 7-interacting protein 1

1

8

High-throughput

0.457

High

277998

TAU
Microtubule-associated protein tau

1

13

High-throughput

0.445

High

278025

BMI1
Polycomb complex protein BMI-1

1

14

High-throughput

0.445

High

278047

TERA
Transitional endoplasmic reticulum ATPase

1

7

High-throughput

0.445

High

278048

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

16

High-throughput

0.445

High

278079

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

7

High-throughput

0.445

High

278100

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

High-throughput

0.445

High

278111

CLC4G
C-type lectin domain family 4 member G

1

7

Small-scale

0.445

High

278133

ESR2
Estrogen receptor beta

1

19

High-throughput

0.445

High

278145

ZBT18
Zinc finger and BTB domain-containing protein 18

1

5

High-throughput

0.445

High

278154

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

11

High-throughput

0.445

High

278155

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

11

High-throughput

0.445

High

273244

T22D2
TSC22 domain family protein 2

1

5

Small-scale

0.439

High

104952

APRIO
Alternative prion protein

1

9

High-throughput

0.437

High

192407

INSI1
Insulin-induced gene 1 protein

1

6

High-throughput

0.437

High

246339

KDM1A
Lysine-specific histone demethylase 1A

1

2

High-throughput

0.437

High

276018

NIPS2
Protein NipSnap homolog 2

1

1

Small-scale

0.437

High

277978

PIAS1
E3 SUMO-protein ligase PIAS1

1

6

High-throughput

0.437

High

277985

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

278005

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.437

High

278019

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.437

High

278026

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

278054

WDR5
WD repeat-containing protein 5

1

15

High-throughput

0.437

High

278092

ZMY11
Zinc finger MYND domain-containing protein 11

1

8

High-throughput

0.437

High

278097

FBX43
F-box only protein 43

1

2

Small-scale

0.437

High

278105

DCA15
DDB1- and CUL4-associated factor 15

1

1

High-throughput

0.437

High

278106

ATG9B
Autophagy-related protein 9B

1

1

Small-scale

0.437

High

278112

LRC31
Leucine-rich repeat-containing protein 31

1

5

High-throughput

0.437

High

278117

KCTD9
BTB/POZ domain-containing protein KCTD9

1

20

High-throughput

0.437

High

278118

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.437

High

278121

MGDP1
Magnesium-dependent phosphatase 1

1

3

High-throughput

0.437

High

278123

SIR6
NAD-dependent protein deacylase sirtuin-6

1

9

Small-scale

0.437

High

278134

TF3B
Transcription factor IIIB 90 kDa subunit

1

1

Small-scale

0.437

High

278135

PF21A
PHD finger protein 21A

1

9

High-throughput

0.437

High

278162

WDR76
WD repeat-containing protein 76

1

20

High-throughput

0.437

High

278180

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

278013

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.426

High

278094

UT2
Urea transporter 2

1

0

High-throughput

0.426

High

278007

TSHR
Thyrotropin receptor

1

11

Small-scale

0.408

High

278016

HEMH
Ferrochelatase, mitochondrial

1

5

High-throughput

0.407

High

278074

CTBP1
C-terminal-binding protein 1

1

5

High-throughput

0.407

High

278101

LITD1
LINE-1 type transposase domain-containing protein 1

1

1

High-throughput

0.407

High

278088

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025